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Haemoglobin B
Hemoglobin subunit beta (beta globin, β-globin, haemoglobin beta, hemoglobin beta) is a globin protein, coded for by the ''HBB'' gene, which along with alpha globin (HBA1, HBA), makes up the most common form of haemoglobin in adult humans, hemoglobin A (HbA). It is 147 amino acids long and has a molecular weight of 15,867 dalton (unit), Da. Normal adult human HbA is a tetrameric protein, heterotetramer consisting of two alpha chains and two beta chains. HBB is encoded by the ''HBB'' gene on Chromosome 11 (human), human chromosome 11. Mutations in the gene produce several variants of the proteins which are implicated with genetic disorders such as sickle-cell disease and beta thalassemia, as well as beneficial traits such as genetic resistance to malaria. At least 50 disease-causing mutations in this gene have been discovered. Gene locus HBB protein is produced by the gene ''HBB'' which is located in the multigene locus of Human β-globin locus, β-globin locus on Chromosome ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
HBB Location
Hemoglobin subunit beta (beta globin, β-globin, haemoglobin beta, hemoglobin beta) is a globin protein, coded for by the ''HBB'' gene, which along with alpha globin (HBA1, HBA), makes up the most common form of haemoglobin in adult humans, hemoglobin A (HbA). It is 147 amino acids long and has a molecular weight of 15,867 dalton (unit), Da. Normal adult human HbA is a tetrameric protein, heterotetramer consisting of two alpha chains and two beta chains. HBB is encoded by the ''HBB'' gene on Chromosome 11 (human), human chromosome 11. Mutations in the gene produce several variants of the proteins which are implicated with genetic disorders such as sickle-cell disease and beta thalassemia, as well as beneficial traits such as genetic resistance to malaria. At least 50 disease-causing mutations in this gene have been discovered. Gene locus HBB protein is produced by the gene ''HBB'' which is located in the multigene locus of Human β-globin locus, β-globin locus on Chromosome ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
