External Capsules
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External Capsules
The external capsule is a series of white matter fiber tracts in the brain. These fibers run between the most lateral (toward the side of the head) segment of the lentiform nucleus (more specifically the putamen) and the claustrum. The white matter of the external capsule contains fibers known as corticocortical association fibers. These fibers are responsible for connecting the cerebral cortex to another cortical area. The capsule itself appears as a thin white sheet of white matter. The external capsule is a route for cholinergic fibers from the basal forebrain to the cerebral cortex. The putamen separates the external capsule from the internal capsule medially and the claustrum separates it from the extreme capsule laterally. But the external capsule eventually joins the internal capsule The internal capsule is a white matter structure situated in the inferomedial part of each cerebral hemisphere of the brain. It carries information past the basal ganglia, separating the cau ...
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Horizontal Section
The transverse plane (also known as the horizontal plane, axial plane and transaxial plane) is an anatomical plane that divides the body into superior and inferior sections. It is perpendicular to the coronal and sagittal planes. List of clinically relevant anatomical planes * Transverse ''thoracic plane'' * '' Xiphosternal plane'' (or xiphosternal junction) * ''Transpyloric plane'' * ''Subcostal plane'' * '' Umbilical plane'' (or transumbilical plane) * '' Supracristal plane'' * ''Intertubercular plane'' (or transtubercular plane) * ''Interspinous plane'' Clinically relevant anatomical planes with associated structures * The transverse ''thoracic plane'' ** Plane through T4 & T5 vertebral junction and sternal angle of Louis. ** Marks the: *** Attachment of costal cartilage of rib 2 at the sternal angle; *** Aortic arch (beginning and end); *** Upper margin of SVC; *** Thoracic duct crossing; *** Tracheal bifurcation; *** Pulmonary trunk bifurcation; * The '' xiphosternal ...
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Cerebral Hemisphere
The vertebrate cerebrum (brain) is formed by two cerebral hemispheres that are separated by a groove, the longitudinal fissure. The brain can thus be described as being divided into left and right cerebral hemispheres. Each of these hemispheres has an outer layer of grey matter, the cerebral cortex, that is supported by an inner layer of white matter. In eutherian (placental) mammals, the hemispheres are linked by the corpus callosum, a very large bundle of nerve fibers. Smaller commissures, including the anterior commissure, the posterior commissure and the fornix, also join the hemispheres and these are also present in other vertebrates. These commissures transfer information between the two hemispheres to coordinate localized functions. There are three known poles of the cerebral hemispheres: the ''occipital pole'', the ''frontal pole'', and the ''temporal pole''. The central sulcus is a prominent fissure which separates the parietal lobe from the frontal lobe and the prim ...
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White Matter
White matter refers to areas of the central nervous system (CNS) that are mainly made up of myelinated axons, also called tracts. Long thought to be passive tissue, white matter affects learning and brain functions, modulating the distribution of action potentials, acting as a relay and coordinating communication between different brain regions. White matter is named for its relatively light appearance resulting from the lipid content of myelin. However, the tissue of the freshly cut brain appears pinkish-white to the naked eye because myelin is composed largely of lipid tissue veined with capillaries. Its white color in prepared specimens is due to its usual preservation in formaldehyde. Structure White matter White matter is composed of bundles, which connect various grey matter areas (the locations of nerve cell bodies) of the brain to each other, and carry nerve impulses between neurons. Myelin acts as an insulator, which allows electrical signals to jump, rather than c ...
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Brain
A brain is an organ that serves as the center of the nervous system in all vertebrate and most invertebrate animals. It is located in the head, usually close to the sensory organs for senses such as vision. It is the most complex organ in a vertebrate's body. In a human, the cerebral cortex contains approximately 14–16 billion neurons, and the estimated number of neurons in the cerebellum is 55–70 billion. Each neuron is connected by synapses to several thousand other neurons. These neurons typically communicate with one another by means of long fibers called axons, which carry trains of signal pulses called action potentials to distant parts of the brain or body targeting specific recipient cells. Physiologically, brains exert centralized control over a body's other organs. They act on the rest of the body both by generating patterns of muscle activity and by driving the secretion of chemicals called hormones. This centralized control allows rapid and coordinated respon ...
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Lentiform Nucleus
The lentiform nucleus, or lenticular nucleus, comprises the putamen and the globus pallidus within the basal ganglia. With the caudate nucleus, it forms the dorsal striatum. It is a large, lens-shaped mass of gray matter just lateral to the internal capsule. Structure When divided horizontally, it exhibits, to some extent, the appearance of a biconvex lens, while a coronal section of its central part presents a somewhat triangular outline. It is shorter than the caudate nucleus and does not extend as far forward. Boundaries It is lateral to the caudate nucleus and thalamus, and is seen only in sections of the hemisphere. It is bounded laterally by a lamina of white substance called the external capsule, and lateral to this is a thin layer of gray substance termed the claustrum. Its anterior end is continuous with the lower part of the head of the caudate nucleus and with the anterior perforated substance. Components In a coronal section through the middle of the lentiform nu ...
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Putamen
The putamen (; from Latin, meaning "nutshell") is a round structure located at the base of the forebrain (telencephalon). The putamen and caudate nucleus together form the dorsal striatum. It is also one of the structures that compose the basal nuclei. Through various pathways, the putamen is connected to the substantia nigra, the globus pallidus, the claustrum, and the thalamus, in addition to many regions of the cerebral cortex. A primary function of the putamen is to regulate movements at various stages (e.g. preparation and execution) and influence various types of learning. It employs GABA, acetylcholine, and enkephalin to perform its functions. The putamen also plays a role in degenerative neurological disorders, such as Parkinson's disease. History The word "putamen" is from Latin, referring to that which "falls off in pruning", from "putare", meaning "to prune, to think, or to consider". Until recently, most MRI research focused broadly on the basal ganglia as a who ...
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Claustrum
The claustrum (Latin, meaning "to close" or "to shut") is a thin, bilateral collection of neurons and supporting glial cells, that connects to cortical (e.g., the pre-frontal cortex) and subcortical regions (e.g., the thalamus) of the brain. It is located between the insula medially and the putamen laterally, separated by the extreme and external capsules respectively. The blood supply to the claustrum is fulfilled via the middle cerebral artery. It is considered to be the most densely connected structure in the brain, allowing for integration of various cortical inputs (e.g., colour, sound and touch) into one experience rather than singular events. The claustrum is difficult to study given the limited number of individuals with claustral lesions and the poor resolution of neuroimaging. The claustrum is made up of various cell types differing in size, shape and neurochemical composition. Five cell types exist, and a majority of these cells resemble pyramidal neurons found in ...
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Association Fibers
Association fibers are axons that connect cortical areas within the same cerebral hemisphere. In human neuroanatomy, axons (nerve fibers) within the brain, can be categorized on the basis of their course and connections as association fibers, projection fibers, and commissural fibers. The association fibers unite different parts of the same cerebral hemisphere, and are of two kinds: (1) short association fibers that connect adjacent gyri; (2) long association fibers that make connections between more distant parts. Short association fibers Many of the short association fibers (also called arcuate or "U"-fibers) lie immediately beneath the gray substance of the cortex of the hemispheres, and connect together adjacent gyri. Some pass from one wall of the sulcus to the other. Long association fibers The long association fibers connect the more widely separated gyri and are grouped into bundles. They include the following: Diffusion tensor imaging is a non-invasive method t ...
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Cerebral Cortex
The cerebral cortex, also known as the cerebral mantle, is the outer layer of neural tissue of the cerebrum of the brain in humans and other mammals. The cerebral cortex mostly consists of the six-layered neocortex, with just 10% consisting of allocortex. It is separated into two cortices, by the longitudinal fissure that divides the cerebrum into the left and right cerebral hemispheres. The two hemispheres are joined beneath the cortex by the corpus callosum. The cerebral cortex is the largest site of neural integration in the central nervous system. It plays a key role in attention, perception, awareness, thought, memory, language, and consciousness. The cerebral cortex is part of the brain responsible for cognition. In most mammals, apart from small mammals that have small brains, the cerebral cortex is folded, providing a greater surface area in the confined volume of the cranium. Apart from minimising brain and cranial volume, cortical folding is crucial for the brain ...
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Cholinergic
Cholinergic agents are compounds which mimic the action of acetylcholine and/or butyrylcholine. In general, the word "choline" describes the various quaternary ammonium salts containing the ''N'',''N'',''N''-trimethylethanolammonium cation. Found in most animal tissues, choline is a primary component of the neurotransmitter acetylcholine and functions with inositol as a basic constituent of lecithin. Choline also prevents fat deposits in the liver and facilitates the movement of fats into cells. The parasympathetic nervous system, which uses acetylcholine almost exclusively to send its messages, is said to be almost entirely cholinergic. Neuromuscular junctions, preganglionic neurons of the sympathetic nervous system, the basal forebrain, and brain stem complexes are also cholinergic, as are the receptor for the merocrine sweat glands. In neuroscience and related fields, the term cholinergic is used in these related contexts: * A substance (or ligand) is cholinergic if it ...
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Basal Forebrain
Part of the human brain, the basal forebrain structures are located in the forebrain to the front of and below the striatum. They include the ventral basal ganglia (including nucleus accumbens and ventral pallidum), nucleus basalis, diagonal band of Broca, substantia innominata, and the medial septal nucleus. These structures are important in the production of acetylcholine, which is then distributed widely throughout the brain. The basal forebrain is considered to be the major cholinergic output of the central nervous system (CNS) centred on the output of the nucleus basalis. The presence of non-cholinergic neurons projecting to the cortex have been found to act with the cholinergic neurons to dynamically modulate activity in the cortex. Function Acetylcholine is known to promote wakefulness in the basal forebrain. Stimulating the basal forebrain gives rise to acetylcholine release, which induces wakefulness and REM sleep, whereas inhibition of acetylcholine release in the basa ...
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Internal Capsule
The internal capsule is a white matter structure situated in the inferomedial part of each cerebral hemisphere of the brain. It carries information past the basal ganglia, separating the caudate nucleus and the thalamus from the putamen and the globus pallidus. The internal capsule contains both ascending and descending axons, going to and coming from the cerebral cortex. It also separates the caudate nucleus and the putamen in the dorsal striatum, a brain region involved in motor and reward pathways. The corticospinal tract constitutes a large part of the internal capsule, carrying motor information from the primary motor cortex to the lower motor neurons in the spinal cord. Above the basal ganglia the corticospinal tract is a part of the corona radiata. Below the basal ganglia the tract is called cerebral crus (a part of the cerebral peduncle) and below the pons it is referred to as the corticospinal tract. Structure The internal capsule consists of three parts and is V-shap ...
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