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Equine Chorionic Gonadotropin
Equine chorionic gonadotropin (acronym given as eCG but not to be confused with ECG) is a gonadotropin, gonadotropic hormone produced in the chorion of pregnant mares. Previously referred to as pregnant mare's Blood serum, serum gonadotropin (PMSG), the hormone is commonly used in concert with progestogen to induce ovulation in livestock prior to artificial insemination. Pregnant mares secrete the hormone from their endometrial cups between 40 and 130 days into their gestation, and once collected, it has been used to artificially induce estrus in female sheep, goats, cattle, and swine. Despite being less pure than pituitary extracts from sheep, goats or swine, PMSG tends to be used because of its longer circulatory half-life. In equids PMSG has only LH like activity, but in other species it has activity like both follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Equine CG, like all glycoprotein hormones, is composed of two dissimilar subunits named alpha and beta. The ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gonadotropin
Gonadotropins are glycoprotein hormones secreted by gonadotropic cells of the anterior pituitary of vertebrates. This family includes the mammalian hormones follicle-stimulating hormone (FSH) and luteinizing hormone (LH), the placental/ chorionic gonadotropins, human chorionic gonadotropin (hCG) and equine chorionic gonadotropin (eCG), as well as at least two forms of fish gonadotropins. These hormones are central to the complex endocrine system that regulates normal growth, sexual development, and reproductive function. LH and FSH are secreted by the anterior pituitary gland, while hCG and eCG are secreted by the placenta in pregnant humans and mares, respectively. The gonadotropins act on the gonads, controlling gamete and sex hormone production. Gonadotropin is sometimes abbreviated ''Gn''. The alternative spelling ''gonadotrophin'' which inaccurately implies a nourishing mechanism is also used. There are various preparations of gonadotropins for therapeutic use, mainly a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pituitary
In vertebrate anatomy, the pituitary gland, or hypophysis, is an endocrine gland, about the size of a chickpea and weighing, on average, in humans. It is a protrusion off the bottom of the hypothalamus at the base of the brain. The hypophysis rests upon the hypophyseal fossa of the sphenoid bone in the center of the middle cranial fossa and is surrounded by a small bony cavity (sella turcica) covered by a dural fold (diaphragma sellae). The anterior pituitary (or adenohypophysis) is a lobe of the gland that regulates several physiological processes including stress, growth, reproduction, and lactation. The intermediate lobe synthesizes and secretes melanocyte-stimulating hormone. The posterior pituitary (or neurohypophysis) is a lobe of the gland that is functionally connected to the hypothalamus by the median eminence via a small tube called the pituitary stalk (also called the infundibular stalk or the infundibulum). Hormones secreted from the pituitary gland help t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Blackwell Publishing
Wiley-Blackwell is an international scientific, technical, medical, and scholarly publishing business of John Wiley & Sons. It was formed by the merger of John Wiley & Sons Global Scientific, Technical, and Medical business with Blackwell Publishing in 2007.About Wiley-Blackwell John Wiley & Sons, Inc. Wiley-Blackwell is now an imprint that publishes a diverse range of academic and professional fields, including , , , |
CAB International
CABI (legally CAB International, formerly Commonwealth Agricultural Bureaux) is a nonprofit intergovernmental development and information organisation focusing primarily on agricultural and environmental issues in the developing world, and the creation, curation, and dissemination of scientific knowledge. Overview CABI is an international not-for-profit organisation. Their work is delivered through teams of CABI scientists and key partners working in over 40 countries across the world. CABI states its mission as "improving people’s lives worldwide by solving problems in agriculture and the environment". These problems include loss of crops caused by pests and diseases, invasive weeds and pests that damage farm production and biodiversity, and lack of global access to scientific research. Funding CABI states that only 3% of its revenue comes from core funding. Donors listed in the company's 2014 financial report include the UK's Department for International Development (£4, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mitteldeutscher Rundfunk
Mitteldeutscher Rundfunk (MDR; ''Central German Broadcasting'') is the public broadcaster for the federal states of Thuringia, Saxony and Saxony-Anhalt in Germany. Established in January 1991, its headquarters are in Leipzig, with regional studios in Dresden, Erfurt and Magdeburg. MDR is a member of the ARD consortium of public broadcasters in Germany. MDR broadcasts its own television channel to the three states it serves and also contributes programming to the first German TV channel ( Das Erste), and broadcasts a number of radio channels. History Origins The Mitteldeutsche Rundfunk AG (MIRAG) was founded on 22 January 1924 in Leipzig. It aired its first program on 1 March 1924 at 14:30 CET. During the '' Gleichschaltung'' in the Nazi era, the MIRAG was transferred to the "Reichssender Leipzig" in 1934. After the end of the Second World War, the Soviet Military Administration in Germany temporarily licensed "Radio Leipzig" in 1945, which only existed for a few months unti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Süddeutsche Zeitung
The ''Süddeutsche Zeitung'' (; ), published in Munich, Bavaria, is one of the largest daily newspapers in Germany. The tone of SZ is mainly described as centre-left, liberal, social-liberal, progressive-liberal, and social-democrat. History On 6 October 1945, five months after the end of World War II in Germany, the ''SZ'' was the first newspaper to receive a license from the US military administration of Bavaria. Thfirst issuewas published the same evening, allegedly printed from the same (repurposed) presses that had printed ''Mein Kampf''. The first article begins with: Declines in ad sales in the early 2000s was so severe that the paper was on the brink of bankruptcy in October 2002. The Süddeutsche survived through a 150 million euro investment by a new shareholder, a regional newspaper chain called Südwestdeutsche Medien. Over a period of three years, the newspaper underwent a reduction in its staff, from 425 to 307, the closing of a regional edition in Düsseldor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Placental
Placental mammals (infraclass Placentalia ) are one of the three extant subdivisions of the class Mammalia, the other two being Monotremata and Marsupial Marsupials are any members of the mammalian infraclass Marsupialia. All extant marsupials are endemic to Australasia, Wallacea and the Americas. A distinctive characteristic common to most of these species is that the young are carried in a po ...ia. Placentalia contains the vast majority of extant mammals, which are partly distinguished from monotremes and marsupials in that the fetus (biology), fetus is carried in the uterus of its mother to a relatively late stage of development. The name is something of a misnomer considering that marsupials also nourish their fetuses via a placenta, though for a relatively briefer period, giving birth to less developed young which are then nurtured for a period inside the mother's pouch (marsupial), pouch. Anatomical features Placental mammals are anatomically distinguished from othe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Equidae
Equidae (sometimes known as the horse family) is the taxonomic family of horses and related animals, including the extant horses, asses, and zebras, and many other species known only from fossils. All extant species are in the genus '' Equus'', which originated in North America. Equidae belongs to the order Perissodactyla, which includes the extant tapirs and rhinoceros, and several extinct families. The term equid refers to any member of this family, including any equine. Evolution The oldest known fossils assigned to Equidae were found in North America, and date from the early Eocene epoch, 54 million years ago. They were once assigned to the genus ''Hyracotherium'', but the type species of that genus is now regarded as a palaeothere. The other species have been split off into different genera. These early equids were fox-sized animals with three toes on the hind feet, and four on the front feet. They were herbivorous browsers on relatively soft plants, and already adapte ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Luteinizing Hormone/choriogonadotropin Receptor
The luteinizing hormone/choriogonadotropin receptor (LHCGR), also lutropin/choriogonadotropin receptor (LCGR) or luteinizing hormone receptor (LHR) is a transmembrane receptor found predominantly in the ovary and testis, but also many extragonadal organs such as the uterus and breasts. The receptor interacts with both luteinizing hormone (LH) and chorionic gonadotropins (such as hCG in humans) and represents a G protein-coupled receptor (GPCR). Its activation is necessary for the hormonal functioning during reproduction. LHCGR gene The gene for the LHCGR is found on chromosome 2 p21 in humans, close to the FSH receptor gene. It consists of 70 kbp (versus 54 kpb for the FSHR). The gene is similar to the gene for the FSH receptor and the TSH receptor. Receptor structure The LHCGR consists of 674 amino acids and has a molecular mass of about 85–95 kDA based on the extent of glycosylation. Like other GPCRs, the LHCG receptor possess seven membrane-spanning domains or transme ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Receptor Binding
In biochemistry and pharmacology, receptors are chemical structures, composed of protein, that receive and transduce signals that may be integrated into biological systems. These signals are typically chemical messengers which bind to a receptor and cause some form of cellular/tissue response, e.g. a change in the electrical activity of a cell. There are three main ways the action of the receptor can be classified: relay of signal, amplification, or integration. Relaying sends the signal onward, amplification increases the effect of a single ligand, and integration allows the signal to be incorporated into another biochemical pathway. Receptor proteins can be classified by their location. Transmembrane receptors include ligand-gated ion channels, G protein-coupled receptors, and enzyme-linked hormone receptors. Intracellular receptors are those found inside the cell, and include cytoplasmic receptors and nuclear receptors. A molecule that binds to a receptor is called a ligand a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Luteinizing Hormone
Luteinizing hormone (LH, also known as luteinising hormone, lutropin and sometimes lutrophin) is a hormone produced by gonadotropic cells in the anterior pituitary gland. The production of LH is regulated by gonadotropin-releasing hormone (GnRH) from the hypothalamus. In females, an acute rise of LH known as an LH surge, triggers ovulation and development of the corpus luteum. In males, where LH had also been called interstitial cell–stimulating hormone (ICSH), it stimulates Leydig cell production of testosterone. It acts synergistically with follicle-stimulating hormone (Follicle-stimulating hormone, FSH). Structure LH is a heteroprotein dimer, dimeric glycoprotein. Each monomeric unit is a glycoprotein molecule; one alpha and one beta subunit make the full, functional protein. Its structure is similar to that of the other glycoprotein hormones, follicle-stimulating hormone (FSH), thyroid-stimulating hormone (TSH), and human chorionic gonadotropin (hCG). The protein dimer ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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