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Dapivirine
Dapivirine is a non-nucleoside reverse transcriptase inhibitor developed at Janssen Therapeutics (formerly Tibotec Therapeutics). The International Partnership for Microbicides has held exclusive worldwide rights to dapivirine since 2014, building upon a 2004 royalty-free license to develop dapivirine-based microbicides for women in resource-poor countries. A monthly intravaginal ring containing dapivirine has been developed as a way of preventing infection by human immunodeficiency virus in women. Two phase 3 clinical trials of intravaginal dapivirine rings for HIV prevention were completed in 2015 and results were announced at the 2016 Conference on Retroviruses and Opportunistic Infections The Conference on Retroviruses and Opportunistic Infections (CROI) is an annual scientific meeting devoted to the understanding, prevention and treatment of HIV/AIDS and the opportunistic infection An opportunistic infection is an infection ca .... The ASPIRE Study (MTN-020) reported ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dapivirine Ring
Dapivirine (DPV) Ring is an antiretroviral vaginal ring pioneered by the International Partnership for Microbicides (IPM) pending for regulatory review. It is designed as a long-acting form of Prevention of HIV/AIDS, HIV prevention for at-risk women, particularly in Developing country, developing nations such as sub-Saharan Africa. IPM has rights to both the medication and the medical device. A total of four rings with different drug Modified-release dosage, diffusion systems and polymer composition have been developed by IPM. The latest design, Ring-004, is a Silicone elastomer, silicone polymer Modified-release dosage, matrix-type system capable of delivering DPV intravaginally in a Sustained release, sustained manner. From 2009 to 2012, two Phase I study, Phase I and one Phase I/II safety trials of the DPV ring were conducted by IPM. Results deemed the device to be well-tolerated and safe. In 2012, two Phase III clinical trials, Phase III studies were sequentially launched–– ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
