Tibotec was a pharmaceutical company with a focus on

research Research is "creative and systematic work undertaken to increase the stock of knowledge". It involves the collection, organization and analysis of evidence to increase understanding of a topic, characterized by a particular attentiveness t ...

and development for the treatment of infectious diseases such as

HIV/AIDS Human immunodeficiency virus infection and acquired immunodeficiency syndrome (HIV/AIDS) is a spectrum of conditions caused by infection with the human immunodeficiency virus (HIV), a retrovirus. Following initial infection an individual ...

and

hepatitis C Hepatitis C is an infectious disease caused by the hepatitis C virus (HCV) that primarily affects the liver; it is a type of viral hepatitis. During the initial infection people often have mild or no symptoms. Occasionally a fever, dark urine, ...

. The company was founded in 1994 and then acquired by Johnson & Johnson and merged into its Janssen Pharmaceuticals division in 2002.

History

In 1994,

Rudi Pauwels Rudi Pauwels (born 1960) is a Belgian pharmacologist and biotech entrepreneur. He studied pharmaceutical sciences at the Katholieke Universiteit Leuven (KU Leuven), Belgium. As one of the first researchers in the field of HIV, he played a key ...

of the Rega Institute for Medical Research founded Tibotec, together with his wife Carine Claeys, and their first co-workers Marie-Pierre de Béthune, Kurt Hertogs, and Hilde Azijn. In 1995

Paul Stoffels Paul, Baron Stoffels (born 8 March 1962 in Turnhout, Belgium) is a Belgian MD, who studied medicine at the University of Hasselt and the University of Antwerp (UA). In addition he studied Infectious Diseases and Tropical Medicine at the Prince Leo ...

( Janssen Pharmaceuticals) joined Tibotec. The company was acquired by Johnson & Johnson in April 2002. The name of the company is derived from the ''tetrahydro-imidazo ,5,1-jk1,4]-benzodiazepine-2(1H)-one and -thione'' (TIBO) compounds discovered at the Rega Institute for Medical Research (

Belgium Belgium, ; french: Belgique ; german: Belgien officially the Kingdom of Belgium, is a country in Northwestern Europe. The country is bordered by the Netherlands to the north, Germany to the east, Luxembourg to the southeast, France to ...

Drugs

* Darunavir (TMC114, tradename Prezista), a protease inhibitor * Etravirine (TMC125, tradename Intelence), a

non-nucleoside reverse transcriptase inhibitor Reverse-transcriptase inhibitors (RTIs) are a class of antiretroviral drugs used to treat HIV infection or AIDS, and in some cases hepatitis B. RTIs inhibit activity of reverse transcriptase, a viral DNA polymerase that is required for replication ...

(NNRTI) * Bedaquiline (TMC207/R207910, tradename Sirturo), an diarylquinoline anti-

tuberculosis Tuberculosis (TB) is an infectious disease usually caused by ''Mycobacterium tuberculosis'' (MTB) bacteria. Tuberculosis generally affects the lungs, but it can also affect other parts of the body. Most infections show no symptoms, in w ...

drug * Rilpivirine (TMC278, tradename Edurant), an NNRTI * Simeprevir (TMC435, tradename Olysio), an HCV NS3/4A protease inhibitor for treatment of chronic hepatitis C in combination with pegylated interferon/ribavirin or with other direct-acting anti-HCV agents.Zeuzem S, Berg T, Gane E, et al. (2012). TMC435 in HCV Genotype 1 Patients Who Have Failed Previous Pegylated Interferon/Ribavirin Treatment: Final SVR24 Results of the ASPIRE Trial. 47th Annual Meeting of the European Association for the Study of the Liver. Barcelona, April 18–22, 2012. Abstract 2. * Dapivirine (TMC120), an NNRTI licensed to the International Partnership for Microbicides for its development as a vaginal microbicide in March 2004.

References

External links

Tibotec
{{J&J Pharmaceutical companies of Belgium Johnson & Johnson subsidiaries Pharmaceutical companies established in 1994 Defunct pharmaceutical companies 2002 mergers and acquisitions

History

Drugs

See also

References

External links