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Cyclopia
Cyclopia (named after the Greek mythology character cyclopes) is the most extreme form of holoprosencephaly and is a congenital disorder (birth defect) characterized by the failure of the embryonic prosencephalon to properly divide the orbits of the eye into two cavities. Its incidence is 1 in 16,000 in born animals and 1 in 200 in miscarried fetuses. Signs and symptoms Typically, the nose is either missing or not functional. This deformity (called proboscis) forms above the center eye and is characteristic of a form of cyclopia called rhinencephaly or rhinocephaly. Most such embryos are either naturally aborted or are stillborn upon delivery. Although cyclopia is rare, several cyclopic human babies are preserved in medical museums (e.g. The Vrolik Museum, Amsterdam, Trivandrum Medical College). Some extreme cases of cyclopia have been documented in farm animals (horses, sheep, pigs, and sometimes chickens). In such cases, the nose and mouth fail to form, or the nose grows ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Holoprosencephaly
Holoprosencephaly (HPE) is a cephalic disorder in which the prosencephalon (the forebrain of the embryo) fails to develop into two hemispheres, typically occurring between the 18th and 28th day of gestation. Normally, the forebrain is formed and the face begins to develop in the fifth and sixth weeks of human pregnancy. The condition also occurs in other species. Holoprosencephaly is estimated to occur in approximately 1 in every 250 conceptions and most cases are not compatible with life and result in fetal death in utero due to deformities to the skull and brain. However, holoprosencephaly is still estimated to occur in approximately 1 in every 8,000 live births. When the embryo's forebrain does not divide to form bilateral cerebral hemispheres (the left and right halves of the brain), it causes defects in the development of the face and in brain structure and function. The severity of holoprosencephaly is highly variable. In less severe cases, babies are born with normal or ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Holoprosencephaly
Holoprosencephaly (HPE) is a cephalic disorder in which the prosencephalon (the forebrain of the embryo) fails to develop into two hemispheres, typically occurring between the 18th and 28th day of gestation. Normally, the forebrain is formed and the face begins to develop in the fifth and sixth weeks of human pregnancy. The condition also occurs in other species. Holoprosencephaly is estimated to occur in approximately 1 in every 250 conceptions and most cases are not compatible with life and result in fetal death in utero due to deformities to the skull and brain. However, holoprosencephaly is still estimated to occur in approximately 1 in every 8,000 live births. When the embryo's forebrain does not divide to form bilateral cerebral hemispheres (the left and right halves of the brain), it causes defects in the development of the face and in brain structure and function. The severity of holoprosencephaly is highly variable. In less severe cases, babies are born with normal or ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cyclopes
In Greek mythology and later Roman mythology, the Cyclopes ( ; el, Κύκλωπες, ''Kýklōpes'', "Circle-eyes" or "Round-eyes"; singular Cyclops ; , ''Kýklōps'') are giant one-eyed creatures. Three groups of Cyclopes can be distinguished. In Hesiod's ''Theogony'', the Cyclopes are the three brothers Brontes, Steropes, and Arges, who made for Zeus his weapon the thunderbolt. In Homer's ''Odyssey'', they are an uncivilized group of shepherds, the brethren of Polyphemus encountered by Odysseus. Cyclopes were also famous as the builders of the Cyclopean walls of Mycenae and Tiryns. In ''Cyclops'', the fifth-century BC play by Euripides, a chorus of satyrs offers comic relief based on the encounter of Odysseus and Polyphemus. The third-century BC poet Callimachus makes the Hesiodic Cyclopes the assistants of smith-god Hephaestus; as does Virgil in the Latin epic ''Aeneid'', where he seems to equate the Hesiodic and Homeric Cyclopes. From at least the fifth century BC, Cyc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sonic Hedgehog (protein)
Sonic hedgehog protein (SHH) is encoded for by the ''SHH'' gene. The protein is named after the character ''Sonic the Hedgehog''. This signaling molecule is key in regulating embryonic morphogenesis in all animals. SHH controls organogenesis and the organization of the central nervous system, limbs, digits and many other parts of the body. Sonic hedgehog is a morphogen that patterns the developing embryo using a concentration gradient characterized by the French flag model. This model has a non-uniform distribution of SHH molecules which governs different cell fates according to concentration. Mutations in this gene can cause holoprosencephaly, a failure of splitting in the cerebral hemispheres, as demonstrated in an experiment using SHH knock-out mice in which the forebrain midline failed to develop and instead only a single fused telencephalic vesicle resulted. Sonic hedgehog still plays a role in differentiation, proliferation, and maintenance of adult tissues. Abnormal act ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Proboscis (anomaly)
In teratology, a proboscis is a blind-ended, tube-like structure, commonly located in the middle of the face. It is commonly seen in severe forms of holoprosencephaly that include cyclopia and is usually the result of abnormal development of the nose. Types Proboscis formation is classified in four general types: holoprosencephalic proboscis, lateral nasal proboscis, supernumerary probosci, and disruptive proboscis. Holoprosencephalic proboscis A holoprosencephalic proboscis is found in holoprosencephaly (a condition in which the forebrain of the embryo fails to develop into two hemispheres as it should). In cyclopia or ethmocephaly, proboscis is an abnormally formed nose. In cyclopia, a single eye in the middle of the face is associated with arrhinia (absence of the nose) and usually with proboscis formation above the eye. In ethmocephaly Ethmocephaly is a type of cephalic disorder caused by holoprosencephaly. Ethmocephaly is the rarest phenotypic variant of a group of def ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Glimåkra
Glimåkra is a Urban areas in Sweden, locality situated in Östra Göinge Municipality, Scania County, Sweden with 1,383 inhabitants in 2010. References Populated places in Östra Göinge Municipality Populated places in Skåne County {{Skåne-geo-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Georges-Louis Leclerc, Comte De Buffon
Georges-Louis Leclerc, Comte de Buffon (; 7 September 1707 – 16 April 1788) was a French naturalist, mathematician, cosmologist, and encyclopédiste. His works influenced the next two generations of naturalists, including two prominent French scientists Jean-Baptiste Lamarck and Georges Cuvier. Buffon published thirty-six quarto volumes of his ''Histoire Naturelle'' during his lifetime, with additional volumes based on his notes and further research being published in the two decades following his death. Ernst Mayr wrote that "Truly, Buffon was the father of all thought in natural history in the second half of the 18th century".Mayr, Ernst 1981. ''The Growth of Biological Thought''. Cambridge: Harvard. p 330 Credited with being one of the first naturalists to recognize ecological succession, he was later forced by the theology committee at the University of Paris to recant his theories about geological history and animal evolution because they contradicted the Biblical na ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Marie Marguerite Bihéron
Marie Marguerite Bihéron (17 November 1719 – 18 June 1795) (also known as Marie Catherine Bihéron) was a French anatomist, known for her medical illustrations and wax figure models. Biography Bihéron was the daughter of a French apothecary, born in 1719.Londa L. Schiebinger (1991), ''The Mind Has No Sex? Women in the Origins of Modern Science'', pp.27-30. She studied illustration at the Jardin du RoiAndrew Cunningham, ''The Anatomist Anatomis'd: An Experimental Discipline in Enlightenment Europe'', Ashgate Publishing, 2010, p. and with Madeleine Basseporte, of whom little is known outside of her anatomical drawings, and the memoirs of contemporaries. To procure bodies for her anatomical studies, Bihéron was forced to have them stolen from the military. Frustrated with their rapid putrefaction, Autumn Stanley, ''Mothers and Daughters of Invention: Notes for Revised History of Technology'', Rutgers University Press, 1995. and at the suggestion of Basseporte, Bihéron turne ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sweden
Sweden, formally the Kingdom of Sweden,The United Nations Group of Experts on Geographical Names states that the country's formal name is the Kingdom of SwedenUNGEGN World Geographical Names, Sweden./ref> is a Nordic country located on the Scandinavian Peninsula in Northern Europe. It borders Norway to the west and north, Finland to the east, and is connected to Denmark in the southwest by a bridgetunnel across the Öresund. At , Sweden is the largest Nordic country, the third-largest country in the European Union, and the fifth-largest country in Europe. The capital and largest city is Stockholm. Sweden has a total population of 10.5 million, and a low population density of , with around 87% of Swedes residing in urban areas in the central and southern half of the country. Sweden has a nature dominated by forests and a large amount of lakes, including some of the largest in Europe. Many long rivers run from the Scandes range through the landscape, primarily ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mercure De France
The was originally a French gazette and literary magazine first published in the 17th century, but after several incarnations has evolved as a publisher, and is now part of the Éditions Gallimard publishing group. The gazette was published from 1672 to 1724 (with an interruption in 1674–1677) under the title (sometimes spelled ; 1672–1674) and (1677–1724). The title was changed to in 1724. The gazette was briefly suppressed (under Napoleon) from 1811 to 1815 and ceased publication in 1825. The name was revived in 1890 for both a literary review and (in 1894) a publishing house initially linked with the symbolist movement. Since 1995 has been part of the Éditions Gallimard publishing group. should not be confused with another literary magazine, the (1823–1830). The original ''Mercure galant'' and ''Mercure de France'' The ''Mercure galant'' was founded by the writer Jean Donneau de Visé in 1672. The name refers to the god Mercury, the messenger of the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Colt (horse)
A colt is a male horse, usually below the age of four years. Description The term "colt" only describes young male horses and is not to be confused with foal, which is a horse of either sex less than one year of age. Similarly, a yearling is a horse of either sex between the ages of one and two. A young female horse is called a filly, and a mare once she is an adult animal. In horse racing, particularly for Thoroughbreds in the United Kingdom, a colt is defined as an uncastrated male from the age of two up to and including the age of four. The term is derived from Proto-Germanic *''kultaz'' ("lump, bundle, offspring") and is etymologically related to "child." An adult male horse, if left intact, is called either a "stallion" if used for breeding, or a horse (sometimes full horse); if castrated, it is called a gelding. In some cases, particularly informal nomenclature, a gelding under four years is still called a colt. A rig or ridgling is a male equine with a retained testicle ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
United Kingdom
The United Kingdom of Great Britain and Northern Ireland, commonly known as the United Kingdom (UK) or Britain, is a country in Europe, off the north-western coast of the continental mainland. It comprises England, Scotland, Wales and Northern Ireland. The United Kingdom includes the island of Great Britain, the north-eastern part of the island of Ireland, and many smaller islands within the British Isles. Northern Ireland shares a land border with the Republic of Ireland; otherwise, the United Kingdom is surrounded by the Atlantic Ocean, the North Sea, the English Channel, the Celtic Sea and the Irish Sea. The total area of the United Kingdom is , with an estimated 2020 population of more than 67 million people. The United Kingdom has evolved from a series of annexations, unions and separations of constituent countries over several hundred years. The Treaty of Union between the Kingdom of England (which included Wales, annexed in 1542) and the Kingdom of Scotland in 170 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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