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Creatine Supplements
Creatine ( or ) is an organic compound with the nominal formula (H2N)(HN)CN(CH3)CH2CO2H. It exists in various modifications (tautomers) in solution. Creatine is found in vertebrates where it facilitates recycling of adenosine triphosphate (ATP), primarily in muscle and brain tissue. Recycling is achieved by converting adenosine diphosphate (ADP) back to ATP via donation of phosphate groups. Creatine also acts as a buffer. History Creatine was first identified in 1832 when Michel Eugène Chevreul isolated it from the basified water-extract of skeletal muscle. He later named the crystallized precipitate after the Greek word for meat, κρέας (''kreas''). In 1928, creatine was shown to exist in equilibrium with creatinine. Studies in the 1920s showed that consumption of large amounts of creatine did not result in its excretion. This result pointed to the ability of the body to store creatine, which in turn suggested its use as a dietary supplement. In 1912, Harvard Uni ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sarcosine
Sarcosine, also known as ''N''-methylglycine, or monomethylglycine, is a monopeptide with the formula CH3N(H)CH2CO2H. It exists at neutral pH as the zwitterion CH3N+(H)2CH2CO2−, which can be obtained as a white, water-soluble powder. Like some amino acids, sarcosine converts to a cation at low pH and an anion at high pH, with the respective formulas CH3N+(H)2CH2CO2H and CH3N(H)CH2CO2−. Sarcosine is a close relative of glycine, with a secondary amine in place of the primary amine. Sarcosine is ubiquitous in biological materials. It is used in manufacturing biodegradable surfactants and toothpastes as well as in other applications. Sarcosine is sweet to the taste. Biochemistry Sarcosine is an intermediate and byproduct in glycine synthesis and degradation. Sarcosine is metabolized to glycine by the enzyme sarcosine dehydrogenase, while glycine-''N''-methyl transferase generates sarcosine from glycine. Sarcosine is an amino acid derivative that is naturally found in muscles ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Skeletal Muscle
Skeletal muscles (commonly referred to as muscles) are organs of the vertebrate muscular system and typically are attached by tendons to bones of a skeleton. The muscle cells of skeletal muscles are much longer than in the other types of muscle tissue, and are often known as muscle fibers. The muscle tissue of a skeletal muscle is striated – having a striped appearance due to the arrangement of the sarcomeres. Skeletal muscles are voluntary muscles under the control of the somatic nervous system. The other types of muscle are cardiac muscle which is also striated and smooth muscle which is non-striated; both of these types of muscle tissue are classified as involuntary, or, under the control of the autonomic nervous system. A skeletal muscle contains multiple muscle fascicle, fascicles – bundles of muscle fibers. Each individual fiber, and each muscle is surrounded by a type of connective tissue layer of fascia. Muscle fibers are formed from the cell fusion, fusion of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Colin Jackson
Colin Ray Jackson, (born 18 February 1967) is a Welsh former sprint and hurdling athlete who specialised in the 110 metres hurdles. During a career in which he represented Great Britain and Wales, he won an Olympic silver medal, became world champion twice, World indoor champion once, was undefeated at the European Championships for 12 years and was twice Commonwealth champion. His world record of 12.91 seconds for the 110 m hurdles stood for over 10 years and his 60 metres hurdles world record stood for nearly 27 years. Jackson won his first major medal, a silver, in the 110 m hurdles, aged 19 at the 1986 Commonwealth Games. He soon established himself on the global scene, taking bronze at the 1987 World Championships in Athletics and a silver medal at the 1988 Summer Olympics. After winning another silver in the 60 m hurdles at the 1989 IAAF World Indoor Championships, he won European and Commonwealth gold medals in 1990. The 1993 season saw him reach the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sally Gunnell
Sally Jane Janet Gunnell (born 29 July 1966) is a British former track and field athlete, active between 1984 and 1997, who won the 1992 Olympic gold medal in the 400 metres hurdles. During a golden 24-month period between 1992 and 1994, Gunnell won every international event open to her, claiming Olympic Games, World Championship, European Championship, Commonwealth Games, Goodwill Games, IAAF World Cup and European Cup golds in the event, and breaking the British, European and World records in it. She is the only female British athlete to have won all four 'majors'; Olympic, World, European and Commonwealth titles, and was the first female 400 metres hurdler in history to win the Olympic and World titles and break the world record. Her former world record time of 52.74 secs in 1993, still ranks in the world all-time top ten (as of 2022) and is the current British record. She was named World and European Female Athlete of the Year in 1993, and was made an MBE in 1993 and an O ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Linford Christie
Linford Cicero Christie (born 2 April 1960) is a Jamaican-born British former sprinter. He is the only British man to have won gold medals in the 100 metres at all four major competitions open to British athletes: the Olympic Games, the World Championships, the European Championships and the Commonwealth Games. He was the first European athlete to break the 10-second barrier in the 100 m and still holds the British record in the event. He is a former world indoor record holder over 200 metres, and a former European record holder in the 60 metres, 100 m and 4 × 100 metres relay. He remains one of the most highly decorated British athletes of all-time. By the end of his track career Christie had won 24 medals overall, more than any other British male athlete before or since. In 1993 he was awarded the BBC Sports Personality of the Year. Christie tested positive for a banned stimulant in 1988 during the Seoul Olympics. In 1999 he was suspended for two years by the IAA ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Times
''The Times'' is a British daily national newspaper based in London. It began in 1785 under the title ''The Daily Universal Register'', adopting its current name on 1 January 1788. ''The Times'' and its sister paper ''The Sunday Times'' (founded in 1821) are published by Times Newspapers, since 1981 a subsidiary of News UK, in turn wholly owned by News Corp. ''The Times'' and ''The Sunday Times'', which do not share editorial staff, were founded independently and have only had common ownership since 1966. In general, the political position of ''The Times'' is considered to be centre-right. ''The Times'' is the first newspaper to have borne that name, lending it to numerous other papers around the world, such as ''The Times of India'', ''The New York Times'', and more recently, digital-first publications such as TheTimesBlog.com (Since 2017). In countries where these other titles are popular, the newspaper is often referred to as , or as , although the newspaper is of nationa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Barcelona
Barcelona ( , , ) is a city on the coast of northeastern Spain. It is the capital and largest city of the autonomous community of Catalonia, as well as the second most populous municipality of Spain. With a population of 1.6 million within city limits,Barcelona: Población por municipios y sexo – Instituto Nacional de Estadística. (National Statistics Institute) its urban area extends to numerous neighbouring municipalities within the and is home to around 4.8 million people, making it the [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1992 Summer Olympics
The 1992 Summer Olympics ( es, Juegos Olímpicos de Verano de 1992, ca, Jocs Olímpics d'estiu de 1992), officially known as the Games of the XXV Olympiad ( es, Juegos de la XXV Olimpiada, ca, Jocs de la XXV Olimpíada) and commonly known as Barcelona '92, were an international multi-sport event held from 25 July to 9 August 1992 in Barcelona, Catalonia, Spain. This was the second (after 1968) "Olympic Games" to be held in a Spanish-speaking nation, then followed by the 2018 Summer Youth Olympics in Buenos Aires, Argentina. Beginning in 1994, the International Olympic Committee decided to hold the Summer and Winter Olympics in alternating even-numbered years. The 1992 Summer and Winter Olympics were the last games to be staged in the same year. This games was the second and last two consecutive Olympic games to be held in Western Europe after the 1992 Winter Olympics in Albertville, France held five months earlier. The 1992 Summer Games were the first since the end of the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Phosphocreatine
Phosphocreatine, also known as creatine phosphate (CP) or PCr (Pcr), is a phosphorylated form of creatine that serves as a rapidly mobilizable reserve of high-energy phosphates in skeletal muscle, myocardium and the brain to recycle adenosine triphosphate, the energy currency of the cell. Chemistry In the kidneys, the enzyme AGAT catalyzes the conversion of two amino acids — arginine and glycine — into guanidinoacetate (also called glycocyamine or GAA), which is then transported in the blood to the liver. A methyl group is added to GAA from the amino acid methionine by the enzyme GAMT, forming non-phosphorylated creatine. This is then released into the blood by the liver where it travels mainly to the muscle cells (95% of the body's creatine is in muscles), and to a lesser extent the brain, heart, and pancreas. Once inside the cells it is transformed into phosphocreatine by the enzyme complex creatine kinase. Phosphocreatine is able to donate its phosphate group to conve ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Willey Glover Denis
Willey Glover Denis (February 26, 1879 – January 9, 1929) was an American biochemist and physiologist. She was noted particularly for her collaborations with Otto Folin, including studies of protein metabolism. She was a pioneer in the field of clinical chemistry and the measurement of protein in biological fluids (blood, urine and cerebrospinal fluid. She also developed the first reliable method of assaying lead in body tissue and waste. Biography Denis earned her A.B. in 1899, majoring in modern languages at Tulane's H. Sophie Newcomb Memorial College. She was a member of the local organization which became the Rho Chapter of Chi Omega and she became an initiate of the chapter. She attended Bryn Mawr College for two years, then returned to Tulane, where she was awarded an MA degree. In 1905 she moved to the University of Chicago, pursuing a doctorate in organic chemistry. Her dissertation involved studies of the oxidation of aldehydes, ketones and alcohols. Dennis then ta ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Otto Folin
Otto Knut Olof Folin (April 4, 1867 – October 25, 1934) was a Swedish-born American chemist who is best known for his groundbreaking work at Harvard University on practical micromethods for the determination of the constituents of protein-free blood filtrates and the discovery of creatine phosphate in muscles. Background Folin was born in Åseda, Småland in Sweden. He was the seventh of twelve children of Nils Magnus Folin and Eva Olson. He moved to America at the age of fifteen following two brothers and an aunt who had already settled there. He carried on his schooling in Stillwater, Minnesota. He moved to Minneapolis, Minnesota entering the University of Minnesota and completed his B.S in 1892. Career In 1896, Folin returned to Sweden and began his research in the laboratory of Prof. Olof Hammarsten (1841-1932) at Uppsala University. In 1897, he left to work in the laboratory of the chemist, Ernst Leopold Salkowski at the Pathological Institute of Charité (''Char ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Harvard University
Harvard University is a private Ivy League research university in Cambridge, Massachusetts. Founded in 1636 as Harvard College and named for its first benefactor, the Puritan clergyman John Harvard, it is the oldest institution of higher learning in the United States and one of the most prestigious and highly ranked universities in the world. The university is composed of ten academic faculties plus Harvard Radcliffe Institute. The Faculty of Arts and Sciences offers study in a wide range of undergraduate and graduate academic disciplines, and other faculties offer only graduate degrees, including professional degrees. Harvard has three main campuses: the Cambridge campus centered on Harvard Yard; an adjoining campus immediately across Charles River in the Allston neighborhood of Boston; and the medical campus in Boston's Longwood Medical Area. Harvard's endowment is valued at $50.9 billion, making it the wealthiest academic institution in the world. Endowment inco ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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