Willey Glover Denis (February 26, 1879 – January 9, 1929) was an American

biochemist Biochemists are scientists who are trained in biochemistry. They study chemical processes and chemical transformations in living organisms. Biochemists study DNA, proteins and Cell (biology), cell parts. The word "biochemist" is a portmanteau of ...

and

physiologist Physiology (; ) is the scientific study of functions and mechanisms in a living system. As a sub-discipline of biology, physiology focuses on how organisms, organ systems, individual organs, cells, and biomolecules carry out the chemical a ...

. She was noted particularly for her collaborations with

Otto Folin Otto Knut Olof Folin (April 4, 1867 – October 25, 1934) was a Swedish-born American chemist who is best known for his groundbreaking work at Harvard University on practical micromethods for the determination of the constituents of protein-f ...

, including studies of protein metabolism. She was a pioneer in the field of clinical chemistry and the measurement of protein in biological fluids (blood,

urine Urine is a liquid by-product of metabolism in humans and in many other animals. Urine flows from the kidneys through the ureters to the urinary bladder. Urination results in urine being excretion, excreted from the body through the urethra. Cel ...

and

cerebrospinal fluid Cerebrospinal fluid (CSF) is a clear, colorless body fluid found within the tissue that surrounds the brain and spinal cord of all vertebrates. CSF is produced by specialised ependymal cells in the choroid plexus of the ventricles of the bra ...

. She also developed the first reliable method of assaying lead in body tissue and waste.

Biography

Denis earned her A.B. in 1899, majoring in modern languages at Tulane's

H. Sophie Newcomb Memorial College H. Sophie Newcomb Memorial College, or Newcomb College, was the coordinate women's college of Tulane University located in New Orleans, in the U.S. state of Louisiana. It was founded by Josephine Louise Newcomb in 1886 in memory of her daughter. ...

. She was a member of the local organization which became the Rho Chapter of Chi Omega and she became an initiate of the chapter. She attended

Bryn Mawr College Bryn Mawr College ( ; Welsh: ) is a women's liberal arts college in Bryn Mawr, Pennsylvania. Founded as a Quaker institution in 1885, Bryn Mawr is one of the Seven Sister colleges, a group of elite, historically women's colleges in the United St ...

for two years, then returned to Tulane, where she was awarded an MA degree. In 1905 she moved to the

University of Chicago The University of Chicago (UChicago, Chicago, U of C, or UChi) is a private research university in Chicago, Illinois. Its main campus is located in Chicago's Hyde Park neighborhood. The University of Chicago is consistently ranked among the b ...

, pursuing a doctorate in

organic chemistry Organic chemistry is a subdiscipline within chemistry involving the scientific study of the structure, properties, and reactions of organic compounds and organic materials, i.e., matter in its various forms that contain carbon atoms.Clayden, J.; ...

. Her dissertation involved studies of the oxidation of

aldehyde In organic chemistry, an aldehyde () is an organic compound containing a functional group with the structure . The functional group itself (without the "R" side chain) can be referred to as an aldehyde but can also be classified as a formyl grou ...

ketone In organic chemistry, a ketone is a functional group with the structure R–C(=O)–R', where R and R' can be a variety of carbon-containing substituents. Ketones contain a carbonyl group –C(=O)– (which contains a carbon-oxygen double bo ...

s and alcohols. Dennis then taught at

Grinnell College Grinnell College is a private liberal arts college in Grinnell, Iowa, United States. It was founded in 1846 when a group of New England Congregationalists established the Trustees of Iowa College. Grinnell has the fifth highest endowment-to-st ...

for a year, moving to the

U.S. Department of Agriculture The United States Department of Agriculture (USDA) is the federal executive department responsible for developing and executing federal laws related to farming, forestry, rural economic development, and food. It aims to meet the needs of com ...

where she worked until 1909. After attempts to attend medical school that ended due to harassment, she moved to

Harvard Medical School Harvard Medical School (HMS) is the graduate medical school of Harvard University and is located in the Longwood Medical Area of Boston, Massachusetts. Founded in 1782, HMS is one of the oldest medical schools in the United States and is consi ...

to become a research assistant for

; she worked part-time with Folin for about a decade. In 1920, Denis was appointed to the faculty of

Tulane Medical School The Tulane University School of Medicine is located in New Orleans, Louisiana, United States and is a part of Tulane University. The school is located in the Medical District of the New Orleans Central Business District. History The school was ...

, the first appointment of a woman to a major U.S. medical school. She eventually headed the newly developed department of biological chemistry there. She was also the first woman to be elected a member of the

Massachusetts General Hospital Massachusetts General Hospital (Mass General or MGH) is the original and largest teaching hospital of Harvard Medical School located in the West End neighborhood of Boston, Massachusetts. It is the third oldest general hospital in the United Stat ...

staff.Willey Glover Denis (1879–1929)
Smithsonian Institution Archives (accessed 2014-04-16). Denis died on January 9, 1929, aged 49, from complications from metastatic breast cancer.

Biography

References

See also