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Cosegregation
Co-segregation is the likelihood of two units being inherited to the next generation or an interaction estimation probability between any number of loci. Interaction probability is determined using specified parts of a target gene ( loci) and a group of nuclear profiles (NPs). The picture to the right serves to provide visual aid as to how a slice (NP) is taken from the nucleus and loci are searched for within the NP. Co-segregation used within other mathematical models (SLICE and Normalized Linkage Disequilibrium) assist in rendering 3-D visualizations as a smaller process of Genome Architecture Mapping (GAM). These renderings help determine genomic density and radial position. History Co-segregation in Genome Architecture Mapping (GAM) is a newer process being used to identify the compaction and adjacency of genomic windows. In a study from 2017, co-segregation was used to understand gene-expression-specific contacts in organizing the genome in mammalian nuclei in the la ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genome Architecture Mapping
In molecular biology, genome architecture mapping (GAM) is a cryosectioning method to map colocalized DNA regions in a ligation independent manner. It overcomes some limitations of Chromosome conformation capture (3C), as these methods have a reliance on digestion and ligation to capture interacting DNA segments. GAM is the first genome-wide method for capturing three-dimensional proximities between any number of genomic loci without ligation. The sections that are found using the cryosectioning method mentioned above are referred to as “Nuclear Profiles”. The information that they provide relates to their coverage across a genome. A large set of values can be produced that represents the strength of nuclear profiles’ presence within a genome. Based on how large or small the coverage across a genome is, judgements can be made involving chromatin interactions, nuclear profile location within the nucleus being cryosectioned, and chromatin compaction levels. To be able to vi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cosegregation To Adjacency
Co-segregation is the likelihood of two units being inherited to the next generation or an interaction estimation probability between any number of loci. Interaction probability is determined using specified parts of a target gene (loci Locus (plural loci) is Latin for "place". It may refer to: Entertainment * Locus (comics), a Marvel Comics mutant villainess, a member of the Mutant Liberation Front * ''Locus'' (magazine), science fiction and fantasy magazine ** '' Locus Award ...) and a group of nuclear profiles (NPs). The picture to the right serves to provide visual aid as to how a slice (NP) is taken from the nucleus and loci are searched for within the NP. Co-segregation used within other mathematical models (SLICE and Normalized Linkage Disequilibrium) assist in rendering 3-D visualizations as a smaller process of Genome Architecture Mapping (GAM). These renderings help determine genomic density and radial position. History Co-segregation in Genome Architecture ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genome With Nuclear Profile Slice And Loci
In the fields of molecular biology and genetics, a genome is all the genetic information of an organism. It consists of nucleotide sequences of DNA (or RNA in RNA viruses). The nuclear genome includes protein-coding genes and non-coding genes, other functional regions of the genome such as regulatory sequences (see non-coding DNA), and often a substantial fraction of 'junk' DNA with no evident function. Almost all eukaryotes have mitochondria and a small mitochondrial genome. Algae and plants also contain chloroplasts with a chloroplast genome. The study of the genome is called genomics. The genomes of many organisms have been sequenced and various regions have been annotated. The International Human Genome Project reported the sequence of the genome for ''Homo sapiens'' in 200The Human Genome Project although the initial "finished" sequence was missing 8% of the genome consisting mostly of repetitive sequences. With advancements in technology that could handle seque ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Colocalization
In fluorescence microscopy, colocalization refers to observation of the spatial overlap between two (or more) different fluorescent labels, each having a separate emission wavelength, to see if the different "targets" are located in the same area of the cell or very near to one another. The definition can be split into two different phenomena, co-occurrence, which refers to the presence of two (possibly unrelated) fluorophores in the same pixel, and correlation, a much more significant statistical relationship between the fluorophores indicative of a biological interaction. This technique is important to many cell biological and physiological studies during the demonstration of a relationship between pairs of bio-molecules. History The ability to demonstrate a correlation between a pair of bio-molecules was greatly enhanced by Erik Manders of the University of Amsterdam who introduced Pearson's correlation coefficient to microscopists, along with other coefficients of which the " ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Graph Theory
In mathematics, graph theory is the study of ''graphs'', which are mathematical structures used to model pairwise relations between objects. A graph in this context is made up of '' vertices'' (also called ''nodes'' or ''points'') which are connected by '' edges'' (also called ''links'' or ''lines''). A distinction is made between undirected graphs, where edges link two vertices symmetrically, and directed graphs, where edges link two vertices asymmetrically. Graphs are one of the principal objects of study in discrete mathematics. Definitions Definitions in graph theory vary. The following are some of the more basic ways of defining graphs and related mathematical structures. Graph In one restricted but very common sense of the term, a graph is an ordered pair G=(V,E) comprising: * V, a set of vertices (also called nodes or points); * E \subseteq \, a set of edges (also called links or lines), which are unordered pairs of vertices (that is, an edge is associated with t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Matrices Of Concepts
The matrices of concepts are a conceptual tool put forth by philosopher Paul Franceschi, that aim at providing an alternative to the semiotic square described by Algirdas Greimas. To the difference of the semiotic square, a matrix of concepts is made up of 6 concepts, from which two are neutral, two are positive and two are negative. The relationships between the 6 concepts of the same matrix can be stated as follows: * A0 and Ā0 are dual or inverse; A+ and Ā− are contraries; A− and Ā+ are contraries * A+ and Ā+ are complementary, in the same way as A− and Ā- * A+ and A− are corollary, in the same way as Ā+ and Ā− * A0 and A+ are related, in the same way as A0 and A−, Ā0 and Ā+, Ā0 and Ā− The applications of the matrices of concepts relate to paradigmatic analysis, but also to the dialectical plan, and more generally to the study of concepts. References * Paul FranceschiEnglish translation of a paper initially published in French under the title ''Le ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
