Clostridia
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Clostridia
The Clostridia are a highly polyphyletic class of Bacillota, including '' Clostridium'' and other similar genera. They are distinguished from the Bacilli by lacking aerobic respiration. They are obligate anaerobes and oxygen is toxic to them. Species of the class ''Clostridia'' are often but not always Gram-positive (see ''Halanaerobium'') and have the ability to form spores. Studies show they are not a monophyletic group, and their relationships are not entirely certain. Currently, most are placed in a single order called Clostridiales, but this is not a natural group and is likely to be redefined in the future. Most species of the genus ''Clostridium'' are saprophytic organisms that ferment plant polysaccharides and are found in many places in the environment, most notably the soil. However, the genus does contain some human pathogens (outlined below). The toxins produced by certain members of the genus ''Clostridium'' are among the most dangerous known. Examples are tetanus ...
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Clostridium
''Clostridium'' is a genus of anaerobic, Gram-positive bacteria. Species of ''Clostridium'' inhabit soils and the intestinal tract of animals, including humans. This genus includes several significant human pathogens, including the causative agents of botulism and tetanus. It also formerly included an important cause of diarrhea, ''Clostridioides difficile'', which was reclassified into the ''Clostridioides'' genus in 2016. History In the late 1700s, Germany experienced a number of outbreaks of an illness that seemed connected to eating certain sausages. In 1817, the German neurologist Justinus Kerner detected rod-shaped cells in his investigations into this so-called sausage poisoning. In 1897, the Belgian biology professor Emile van Ermengem published his finding of an endospore-forming organism he isolated from spoiled ham. Biologists classified van Ermengem's discovery along with other known gram-positive spore formers in the genus ''Bacillus''. This classification prese ...
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Clostridiales
The Eubacteriales are an order of bacteria placed within the class Clostridia. Families Eubacteriales comprises the following families: * " Betainaceae" Jones et al. 2019 * " Bianqueaceae" Liu et al. 2021 * " Borkfalkiaceae" Hildebrand, Pallen & Bork 2020 * Caldicoprobacteraceae Yokoyama et al. 2010 * Christensenellaceae Morotomi, Nagai & Watanabe 2012 * Clostridiaceae Pribram 1933 * Defluviitaleaceae Jabari et al. 2012 * Eubacteriaceae Ludwig et al. 2010 * " Feifaniaceae" Liu et al. 2021 * " Galloscillospiraceae" Gilroy et al. 2021 * Gottschalkiaceae Poehlein et al. 2017c * Hungateiclostridiaceae Zhang et al. 2018b * Lachnospiraceae Rainey 2010 * " Mageeibacillaceae" Hildebrand, Pallen & Bork 2020 * " Mogibacteriaceae" Wylensek et al. 2020 * Oscillospiraceae Peshkoff 1940 * Peptoniphilaceae Johnson et al. 2014 * Peptostreptococcaceae Ezaki 2010 * Ruminococcaceae Rainey 2010 * " Pumilibacteraceae" Afrizal et al. 2021 * Thermohalobacteraceae Spring 2021 * Tissierellaceae W ...
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Eubacteriales
The Eubacteriales are an order of bacteria placed within the class Clostridia. Families Eubacteriales comprises the following families: * " Betainaceae" Jones et al. 2019 * " Bianqueaceae" Liu et al. 2021 * " Borkfalkiaceae" Hildebrand, Pallen & Bork 2020 * Caldicoprobacteraceae Yokoyama et al. 2010 * Christensenellaceae Morotomi, Nagai & Watanabe 2012 * Clostridiaceae Pribram 1933 * Defluviitaleaceae Jabari et al. 2012 * Eubacteriaceae Ludwig et al. 2010 * " Feifaniaceae" Liu et al. 2021 * " Galloscillospiraceae" Gilroy et al. 2021 * Gottschalkiaceae Poehlein et al. 2017c * Hungateiclostridiaceae Zhang et al. 2018b * Lachnospiraceae Rainey 2010 * " Mageeibacillaceae" Hildebrand, Pallen & Bork 2020 * " Mogibacteriaceae" Wylensek et al. 2020 * Oscillospiraceae Peshkoff 1940 * Peptoniphilaceae Johnson et al. 2014 * Peptostreptococcaceae Ezaki 2010 * Ruminococcaceae Rainey 2010 * " Pumilibacteraceae" Afrizal et al. 2021 * Thermohalobacteraceae Spring 2021 * Tissierellaceae W ...
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Bacillota
The Bacillota (synonym Firmicutes) are a phylum of bacteria, most of which have gram-positive cell wall structure. The renaming of phyla such as Firmicutes in 2021 remains controversial among microbiologists, many of whom continue to use the earlier names of long standing in the literature. The name "Firmicutes" was derived from the Latin words for "tough skin," referring to the thick cell wall typical of bacteria in this phylum. Scientists once classified the Firmicutes to include all gram-positive bacteria, but have recently defined them to be of a core group of related forms called the low- G+C group, in contrast to the Actinomycetota. They have round cells, called cocci (singular coccus), or rod-like forms (bacillus). A few Firmicutes, such as ''Megasphaera'', ''Pectinatus'', ''Selenomonas'' and ''Zymophilus'', have a porous pseudo-outer membrane that causes them to stain gram-negative. Many Bacillota (Firmicutes) produce endospores, which are resistant to desiccation and can ...
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Thermoanaerobacteriales
The Thermoanaerobacterales is a polyphyletic order of bacteria placed within the polyphyletic class Clostridia, and encompassing four families: the Thermoanaerobacteraceae, the Thermodesulfobiaceae, the Thermoanaerobacterales Family III. Incertae Sedis, and the Thermoanaerobacterales Family IV. Incertae Sedis, and various unplaced genera. This order is noted for the species' abilities to survive in extreme environments without oxygen and of relatively elevated temperatures for a living being (up to 80-90 °C). An example organism in this order is '' Thermoanaerobacter ethanolicus''.C.Michael Hogan. 2010''Extremophile''. eds. E.Monosson & C.Cleveland, Encyclopedia of Earth. National Council for Science and the Environment, Washington DC./ref> Phylogeny The Thermoanaerobacterales, as previously mentioned, is polyphyletic A polyphyletic group is an assemblage of organisms or other evolving elements that is of mixed evolutionary origin. The term is often applied to grou ...
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Thermosediminibacterales
Thermosediminibacterales is an order of Gram positive bacteria in the class Clostridia The Clostridia are a highly polyphyletic class of Bacillota, including '' Clostridium'' and other similar genera. They are distinguished from the Bacilli by lacking aerobic respiration. They are obligate anaerobes and oxygen is toxic to them. Sp .... References Bacteria orders Clostridia Thermophiles Anaerobes {{clostridia-stub ...
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Clostridium Perfringens
''Clostridium perfringens'' (formerly known as ''C. welchii'', or ''Bacillus welchii'') is a Gram-positive, rod-shaped, anaerobic, spore-forming pathogenic bacterium of the genus '' Clostridium''. ''C. perfringens'' is ever-present in nature and can be found as a normal component of decaying vegetation, marine sediment, the intestinal tract of humans and other vertebrates, insects, and soil. It has the shortest reported generation time of any organism at 6.3 minutes in thioglycolate medium. ''Clostridium perfringens'' is one of the most common causes of food poisoning in the United States, alongside norovirus, ''Salmonella'', '' Campylobacter'', and ''Staphylococcus aureus''. However, it can sometimes be ingested and cause no harm. Infections due to ''C. perfringens'' show evidence of tissue necrosis, bacteremia, emphysematous cholecystitis, and gas gangrene, also known as clostridial myonecrosis. The specific name ''perfringens'' is derived from the Latin ''per'' (meaning " ...
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Tetanospasmin
Tetanus toxin (TeNT) is an extremely potent neurotoxin produced by the vegetative cell of ''Clostridium tetani'' in anaerobic conditions, causing tetanus. It has no known function for clostridia in the soil environment where they are normally encountered. It is also called spasmogenic toxin, tentoxilysin, tetanospasmin or, tetanus neurotoxin. The LD50 of this toxin has been measured to be approximately 2.5–3 ng/kg, making it second only to the related botulinum toxin (LD50 2 ng/kg) as the deadliest toxin in the world. However, these tests are conducted solely on mice, which may react to the toxin differently from humans and other animals. ''C. tetani'' also produces the exotoxin tetanolysin, a hemolysin, that causes destruction of tissues. Distribution Tetanus toxin spreads through tissue spaces into the lymphatic and vascular systems. It enters the nervous system at the neuromuscular junctions and migrates through nerve trunks and into the central nervous sys ...
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Clostridium Tetani
''Clostridium tetani'' is a common soil bacterium and the causative agent of tetanus. Vegetative cells of ''Clostridium tetani'' are usually rod-shaped and up to 2.5 μm long, but they become enlarged and tennis racket- or drumstick-shaped when forming spores. ''C. tetani'' spores are extremely hardy and can be found globally in soil or in the gastrointestinal tract of animals. If inoculated into a wound, ''C. tetani'' can grow and produce a potent toxin, tetanospasmin, which interferes with motor neurons, causing tetanus. The toxin's action can be prevented with tetanus toxoid vaccines, which are often administered to children worldwide. Characteristics ''Clostridium tetani'' is a rod-shaped, Gram-positive bacterium, typically up to 0.5 μm wide and 2.5 μm long. It is motile by way of various flagella that surround its body. ''C. tetani'' cannot grow in the presence of oxygen. It grows best at temperatures ranging from 33 to 37°C. Upon exposure to various conditions, ''C. ...
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Halanaerobiales
The Halanaerobiales are an order of bacteria placed within the class Clostridia, and encompassing two families, the Halanaerobiaceae and the Halobacteroidaceae. Originally placed within the highly polyphyletic class Clostridia, according to the NCBI and LPSN, it is now thought to lie outside the Bacillota. Halanaerobiales are halophilic obligate anaerobes with a fermentative or homoacetogenic metabolism. Phylogeny The currently accepted taxonomy is based on the List of Prokaryotic names with Standing in Nomenclature (LPSN) and National Center for Biotechnology Information (NCBI). See also * List of bacterial orders * List of bacteria genera This article lists the genera of the bacteria. The currently accepted taxonomy is based on the List of Prokaryotic names with Standing in Nomenclature (LPSN) and National Center for Biotechnology Information (NCBI). However many taxonomic names are ... References Further reading Bacteria orders {{clostridia-stub ...
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Natranaerobiales
The Natranaerobiales are an order of bacteria placed within the class Clostridia. This order contains the thermophilic bacterial species ''Natranaerobius thermophilus'' and the related species ''Natranaerobaculum magadiense''. See also * List of bacterial orders * List of bacteria genera This article lists the genera of the bacteria. The currently accepted taxonomy is based on the List of Prokaryotic names with Standing in Nomenclature (LPSN) and National Center for Biotechnology Information (NCBI). However many taxonomic names are ... References {{clostridia-stub ...
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Halanaerobium
''Halanaerobium'' is a Gram-negative, non-endospore-forming, rod-shaped, and strictly anaerobic genus of bacteria from the family Halanaerobiaceae. Phylogeny The currently accepted taxonomy is based on the List of Prokaryotic names with Standing in Nomenclature (LPSN) and National Center for Biotechnology Information (NCBI). See also * List of bacterial orders * List of bacteria genera This article lists the genera of the bacteria. The currently accepted taxonomy is based on the List of Prokaryotic names with Standing in Nomenclature (LPSN) and National Center for Biotechnology Information (NCBI). However many taxonomic names are ... References Clostridia Bacteria genera Taxa described in 1984 {{Bacillota-stub ...
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