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Chronic Progressive Lymphedema
Chronic progressive lymphedema (CPL) is a disease of some breeds of draft horse, whereby the lower legs becomes progressively more swollen. There is no cure; the aim of treatment is to manage the signs and slow progression of the disease. The cause of CPL is not known, although it is suspected that a genetic disorder of elastin metabolism prevents the lymphatic vessels from functioning properly, leading to edema of the lower limbs. CPL resembles the human disease elephantiasis verrucosa nostra. Signs CPL is a progressive disease, which begins below the fetlock and gradually moves up the leg. All legs are affected, the hindlimbs usually more seriously so. Initial signs include thickening, crusting and folding of the skin. These early signs may be hidden by the long hair (feather) on the horse's lower legs. Affected areas are itchy, causing the horse to stamp its feet and rub its legs, and painful, so that the horse may be reluctant to allow its legs to be touched. As CPL progresse ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Draft Horse
A draft horse (US), draught horse (UK) or dray horse (from the Old English ''dragan'' meaning "to draw or haul"; compare Dutch ''dragen'' and German ''tragen'' meaning "to carry" and Danish ''drage'' meaning "to draw" or "to fare"), less often called a carthorse, work horse or heavy horse, is a large horse bred to be a working animal doing hard tasks such as plowing and other farm labor. There are a number of breeds, with varying characteristics, but all share common traits of strength, patience, and a docile temperament which made them indispensable to generations of pre-industrial farmers. Draft horses and draft crossbreds are versatile breeds used today for a multitude of purposes, including farming, draft horse showing, logging, recreation, and other uses. They are also commonly used for crossbreeding, especially to light riding breeds such as the Thoroughbred, for the purpose of creating sport horses of warmblood type. While most draft horses are used for driving, they c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Elastin
Elastin is a protein that in humans is encoded by the ''ELN'' gene. Elastin is a key component of the extracellular matrix in gnathostomes (jawed vertebrates). It is highly elastic and present in connective tissue allowing many tissues in the body to resume their shape after stretching or contracting. Elastin helps skin to return to its original position when it is poked or pinched. Elastin is also an important load-bearing tissue in the bodies of vertebrates and used in places where mechanical energy is required to be stored. Function The ''ELN'' gene encodes a protein that is one of the two components of elastic fibers. The encoded protein is rich in hydrophobic amino acids such as glycine and proline, which form mobile hydrophobic regions bounded by crosslinks between lysine residues. Multiple transcript variants encoding different isoforms have been found for this gene. Elastin's soluble precursor is tropoelastin. The characterization of disorder is consistent with an ent ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Edema
Edema, also spelled oedema, and also known as fluid retention, dropsy, hydropsy and swelling, is the build-up of fluid in the body's Tissue (biology), tissue. Most commonly, the legs or arms are affected. Symptoms may include skin which feels tight, the area may feel heavy, and joint stiffness. Other symptoms depend on the underlying cause. Causes may include Chronic venous insufficiency, venous insufficiency, heart failure, kidney problems, hypoalbuminemia, low protein levels, liver problems, deep vein thrombosis, infections, angioedema, certain medications, and lymphedema. It may also occur after prolonged sitting or standing and during menstruation or pregnancy. The condition is more concerning if it starts suddenly, or pain or shortness of breath is present. Treatment depends on the underlying cause. If the underlying mechanism involves Hypernatremia, sodium retention, decreased salt intake and a diuretic may be used. Elevating the legs and support stockings may be useful ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Elephantiasis Nostras
Elephantiasis nostras, is a disease that usually affects the lower legs or scrotum.Lin P, Phillips T. "Vascular Disorders: Ulcers." (2003). In Bolognia JL, Jorizzo JL, Rapini RP (Eds.), ''Dermatology'', p. 1637. Mosby Swelling is accompanied by rough nodules or wart-like plaques on the skin. If the disease is not treated, it eventually results in pain and immobility.Scheinfeld NS. (2009).Skin Disorders in Older Adults: Vascular, Lymphatic, and Purpuric Dermatitides, Part 2. ''Consultant'' 49 (7) The disease can be described as a cutaneous condition, a final hypertrophic fibrosis following long standing chronic lymphangitis. Causes Although elephantiasis nostras resembles the elephantiasis caused by helminths, it is not a filarial disease. Instead, it is a complication of chronic lymphedema. Both elephantiasis nostras and filarial elephantiasis are characterized by impaired lymphatic drainage, which results in excess fluid accumulation. Treatment Treatment consists of antibiot ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Feathering (horse)
Feathering or feather is the long hair on the lower legs of some breeds of horse and pony. On some horses, especially draft breeds, the hair can almost cover the hooves. While nearly all horses will grow longer hair on the lower legs and back of the fetlocks at times, particularly in the winter, "feather" refers to the particularly long growth that is characteristic of certain breeds. Feathering is a characteristic trait of the many of the Mountain and moorland pony breeds of the United Kingdom as well as draught breeds such as the Clydesdale, Shire, Friesian, Ardennes horse The Ardennais or Ardennes is one of the oldest breeds of draft horse, and originates from the Ardennes area in Belgium, Luxembourg, and France. They are heavy-boned with thick legs and are used for draft work. Their history reaches back to A ... and Gypsy Vanner. The trait may appear in crossbreds of these breeds, though to date there has been little scientific study of the trait. References Ho ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Infection
An infection is the invasion of tissues by pathogens, their multiplication, and the reaction of host tissues to the infectious agent and the toxins they produce. An infectious disease, also known as a transmissible disease or communicable disease, is an illness resulting from an infection. Infections can be caused by a wide range of pathogens, most prominently bacteria and viruses. Hosts can fight infections using their immune system. Mammalian hosts react to infections with an innate response, often involving inflammation, followed by an adaptive response. Specific medications used to treat infections include antibiotics, antivirals, antifungals, antiprotozoals, and antihelminthics. Infectious diseases resulted in 9.2 million deaths in 2013 (about 17% of all deaths). The branch of medicine that focuses on infections is referred to as infectious disease. Types Infections are caused by infectious agents (pathogens) including: * Bacteria (e.g. ''Mycobacterium tuberculosis'', ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Thrush (horse)
Thrush is a very common bacterial infection that occurs on the hoof of a horse, specifically in the region of the frog. The bacterium involved is'' Fusobacterium necrophorum'', and occurs naturally in the animal's environment—especially in wet, muddy, or unsanitary conditions, such as an unclean stall—and grows best with low oxygen. Horses with deep clefts, or narrow or contracted heels are more at risk of developing thrush. Symptoms The most obvious sign of thrush is usually the odor that occurs when picking out the feet. Additionally, the infected areas of the hoof will be black in color (even on a dark-horned hoof), and will easily break or crumble when scraped with a hoof pick. When picking the hooves around thrush areas, the differences between healthy and infected areas can be seen when white or gray tissue (healthy frog) is surrounding a dark, smelly (infected) area. Most horses do not become lame if infected with thrush. However, if left untreated, the bacteria may m ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Laminitis
Laminitis is a disease that affects the feet of ungulates and is found mostly in horses and cattle. Clinical signs include foot tenderness progressing to inability to walk, increased digital pulses, and increased temperature in the hooves. Severe cases with outwardly visible clinical signs are known by the colloquial term ''founder'', and progression of the disease will lead to perforation of the coffin bone through the sole of the hoof or being unable to stand up, requiring euthanasia. Laminae The bones of the hoof are suspended within the axial hooves of ungulates by layers of modified skin cells, known as laminae or lamellae, which act as shock absorbers during locomotion. In horses, there are about 550–600 pairs of primary epidermal laminae, each with 150–200 secondary laminae projection from their surface. These interdigitate with equivalent structures on the surface of the coffin bone (PIII, P3, the third phalanx, pedal bone, or distal phalanx), known as dermal lamina ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mange
Mange is a type of skin disease caused by parasitic mites. Because various species of mites also infect plants, birds and reptiles, the term "mange", or colloquially "the mange", suggesting poor condition of the skin and fur due to the infection, is sometimes reserved for pathological mite-infestation of nonhuman mammals. Thus, mange includes mite-associated skin disease in domestic mammals (cats and dogs), in livestock (such as sheep scab), and in wild mammals (for example, foxes, coyotes, cougars, and bears). Since mites belong to the arachnid subclass Acari (also called Acarina), another term for mite infestation is acariasis. Parasitic mites that cause mange in mammals embed themselves in either skin or hair follicles in the animal, depending upon their genus. ''Sarcoptes'' spp. burrow into skin, while ''Demodex'' spp. live in follicles. In humans, these two types of mite infections, which would be known as "mange" in furry mammals, are instead known respectively as scabies ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Shire Horse
The Shire is a British breed of draught horse. It is usually black, bay, or grey. It is a tall breed, and Shires have at various times held world records both for the largest horse and for the tallest horse. The Shire has a great capacity for weight-pulling; it was used for farm work, to tow barges at a time when the canal system was the principal means of goods transport, and as a cart-horse for road transport. One traditional use was for pulling brewer's drays for delivery of beer, and some are still used in this way; others are used for forestry, for riding and for commercial promotion. The Shire breed was established in the mid-eighteenth century, although its origins are much older. A breed society was formed in 1876, and in 1878 the first stud-book was published. In the late nineteenth and early twentieth centuries, there were large numbers of Shires, and many were exported to the United States. With the progressive mechanisation of agriculture and of transport, the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
