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Caerulein
Ceruletide (International Nonproprietary Name, INN), also known as cerulein or caerulein, is a ten amino acid oligopeptide that stimulates smooth muscle and increases digestive secretions. Ceruletide is similar in action and composition to cholecystokinin. It stimulates gastric, biliary, and pancreatic secretion; and certain smooth muscle. It is used in paralytic ileus and as diagnostic aid in pancreatic malfunction. It is used to induce pancreatitis in experimental animal models. Ceruletide was discovered and its structure elucidated in 1967 by Australian and Italian scientists from dried skins of the Australian green tree frog (''Ranoidea caerulea'', formerly ''Hyla caerulea''). Its amino acid sequence is Pglu-Gln-Asp-Tyr[SO3H]-Thr-Gly-Trp-Met-Asp-Phe-NH2. Induction of pancreatitis Ceruletide upregulates pancreatic acinar cell intercellular adhesion molecule-1 (ICAM-1) proteins through intracellular upregulation of NF-κB. Surface ICAM-1 in turn promotes neutrophil adhesi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Australian Green Tree Frog
The Australian green tree frog (''Ranoidea caerulea''), also known as simply green tree frog in Australia, White's tree frog, or dumpy tree frog, is a species of tree frog native to Australia and New Guinea, with introduced populations in the United States and New Zealand, though the latter is believed to have died out. It is morphologically similar to some other members of its genus, particularly the magnificent tree frog (''R. splendida'') and the white-lipped tree frog (''R. infrafrenata''). Larger than most Australian frogs, the Australian green tree frog reaches 10 cm (4 in) or more in length. Its average lifespan in captivity, about 16 years, is long compared with most frogs. Docile and well suited to living near human dwellings, Australian green tree frogs are often found on window sills or inside houses, eating insects drawn by the light. The green tree frog screams when it is in danger to scare off its foe, and squeaks when it is touched. Due to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
