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Biomedical Text Mining
Biomedical text mining (including biomedical natural language processing or BioNLP) refers to the methods and study of how text mining may be applied to texts and literature of the biomedical and molecular biology domains. As a field of research, biomedical text mining incorporates ideas from natural language processing, bioinformatics, medical informatics and computational linguistics. The strategies developed through studies in this field are frequently applied to the biomedical and molecular biology literature available through services such as PubMed. Considerations Applying text mining approaches to biomedical text requires specific considerations common to the domain. Availability of annotated text data Large annotated corpora used in the development and training of general purpose text mining methods (e.g., sets of movie dialogue, product reviews, or Wikipedia article text) are not specific for biomedical language. While they may provide evidence of general text propert ...
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Text Mining
Text mining, also referred to as ''text data mining'', similar to text analytics, is the process of deriving high-quality information from text. It involves "the discovery by computer of new, previously unknown information, by automatically extracting information from different written resources." Written resources may include websites, books, emails, reviews, and articles. High-quality information is typically obtained by devising patterns and trends by means such as statistical pattern learning. According to Hotho et al. (2005) we can distinguish between three different perspectives of text mining: information extraction, data mining, and a KDD (Knowledge Discovery in Databases) process. Text mining usually involves the process of structuring the input text (usually parsing, along with the addition of some derived linguistic features and the removal of others, and subsequent insertion into a database), deriving patterns within the structured data, and finally evaluation and inte ...
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Clinical Decision Support System
A clinical decision support system (CDSS) is a health information technology, provides clinicians, staff, patients, or other individuals with knowledge and person-specific information, to help health and health care. CDSS encompasses a variety of tools to enhance decision-making in the clinical workflow. These tools include computerized alerts and reminders to care providers and patients, clinical guidelines, condition-specific order sets;ยด, focused patient data reports and summaries, documentation templates, diagnostic support, and contextually relevant reference information, among other tools. Robert Hayward of the Centre has proposed a working definition for Health Evidence: "Clinical decision support systems link health observations with health knowledge to influence health choices by clinicians for improved health care". CDSSs constitute a major topic in artificial intelligence in medicine. Characteristics A clinical decision support system is an active knowledge system that ...
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Causal Inference
Causal inference is the process of determining the independent, actual effect of a particular phenomenon that is a component of a larger system. The main difference between causal inference and inference of association is that causal inference analyzes the response of an effect variable when a cause of the effect variable is changed. The science of why things occur is called etiology. Causal inference is said to provide the evidence of causality theorized by causal reasoning. Causal inference is widely studied across all sciences. Several innovations in the development and implementation of methodology designed to determine causality have proliferated in recent decades. Causal inference remains especially difficult where experimentation is difficult or impossible, which is common throughout most sciences. The approaches to causal inference are broadly applicable across all types of scientific disciplines, and many methods of causal inference that were designed for certain discipl ...
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Temporal Information Retrieval
Temporal information retrieval (T-IR) is an emerging area of research related to the field of information retrieval (IR) and a considerable number of sub-areas, positioning itself, as an important dimension in the context of the user information needs. According to information theory science (Metzger, 2007), timeliness or currency is one of the key five aspects that determine a document's credibility besides relevance, accuracy, objectivity and coverage. One can provide many examples when the returned search results are of little value due to temporal problems such as obsolete data on weather, outdated information about a given company's earnings or information on already-happened or invalid predictions. T-IR, in general, aims at satisfying these temporal needs and at combining traditional notions of document relevance with the so-called temporal relevance. This will enable the return of temporally relevant documents, thus providing a temporal overview of the results in the form ...
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K-means Clustering
''k''-means clustering is a method of vector quantization, originally from signal processing, that aims to partition ''n'' observations into ''k'' clusters in which each observation belongs to the cluster with the nearest mean (cluster centers or cluster centroid), serving as a prototype of the cluster. This results in a partitioning of the data space into Voronoi cells. ''k''-means clustering minimizes within-cluster variances (squared Euclidean distances), but not regular Euclidean distances, which would be the more difficult Weber problem: the mean optimizes squared errors, whereas only the geometric median minimizes Euclidean distances. For instance, better Euclidean solutions can be found using k-medians and k-medoids. The problem is computationally difficult (NP-hard); however, efficient heuristic algorithms converge quickly to a local optimum. These are usually similar to the expectation-maximization algorithm for mixtures of Gaussian distributions via an iterative refine ...
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Unsupervised Learning
Unsupervised learning is a type of algorithm that learns patterns from untagged data. The hope is that through mimicry, which is an important mode of learning in people, the machine is forced to build a concise representation of its world and then generate imaginative content from it. In contrast to supervised learning where data is tagged by an expert, e.g. tagged as a "ball" or "fish", unsupervised methods exhibit self-organization that captures patterns as probability densities or a combination of neural feature preferences encoded in the machine's weights and activations. The other levels in the supervision spectrum are reinforcement learning where the machine is given only a numerical performance score as guidance, and semi-supervised learning where a small portion of the data is tagged. Neural networks Tasks vs. methods Neural network tasks are often categorized as discriminative (recognition) or generative (imagination). Often but not always, discriminative tas ...
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Supervised Learning
Supervised learning (SL) is a machine learning paradigm for problems where the available data consists of labelled examples, meaning that each data point contains features (covariates) and an associated label. The goal of supervised learning algorithms is learning a function that maps feature vectors (inputs) to labels (output), based on example input-output pairs. It infers a function from ' consisting of a set of ''training examples''. In supervised learning, each example is a ''pair'' consisting of an input object (typically a vector) and a desired output value (also called the ''supervisory signal''). A supervised learning algorithm analyzes the training data and produces an inferred function, which can be used for mapping new examples. An optimal scenario will allow for the algorithm to correctly determine the class labels for unseen instances. This requires the learning algorithm to generalize from the training data to unseen situations in a "reasonable" way (see inductive b ...
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Document Clustering
Document clustering (or text clustering) is the application of cluster analysis to textual documents. It has applications in automatic document organization, topic extraction and fast information retrieval or filtering. Overview Document clustering involves the use of descriptors and descriptor extraction. Descriptors are sets of words that describe the contents within the cluster. Document clustering is generally considered to be a centralized process. Examples of document clustering include web document clustering for search users. The application of document clustering can be categorized to two types, online and offline. Online applications are usually constrained by efficiency problems when compared to offline applications. Text clustering may be used for different tasks, such as grouping similar documents (news, tweets, etc.) and the analysis of customer/employee feedback, discovering meaningful implicit subjects across all documents. In general, there are two common algorit ...
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Document Classification
Document classification or document categorization is a problem in library science, information science and computer science. The task is to assign a document to one or more classes or categories. This may be done "manually" (or "intellectually") or algorithmically. The intellectual classification of documents has mostly been the province of library science, while the algorithmic classification of documents is mainly in information science and computer science. The problems are overlapping, however, and there is therefore interdisciplinary research on document classification. The documents to be classified may be texts, images, music, etc. Each kind of document possesses its special classification problems. When not otherwise specified, text classification is implied. Documents may be classified according to their subjects or according to other attributes (such as document type, author, printing year etc.). In the rest of this article only subject classification is considered. T ...
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Word Embedding
In natural language processing (NLP), word embedding is a term used for the representation of words for text analysis, typically in the form of a real-valued vector that encodes the meaning of the word such that the words that are closer in the vector space are expected to be similar in meaning. Word embeddings can be obtained using a set of language modeling and feature learning techniques where words or phrases from the vocabulary are mapped to vectors of real numbers. Methods to generate this mapping include neural networks, dimensionality reduction on the word co-occurrence matrix, probabilistic models, explainable knowledge base method, and explicit representation in terms of the context in which words appear. Word and phrase embeddings, when used as the underlying input representation, have been shown to boost the performance in NLP tasks such as syntactic parsing and sentiment analysis. Development and history of the approach In Distributional semantics, a quantitative m ...
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Deep Learning
Deep learning (also known as deep structured learning) is part of a broader family of machine learning methods based on artificial neural networks with representation learning. Learning can be supervised, semi-supervised or unsupervised. Deep-learning architectures such as deep neural networks, deep belief networks, deep reinforcement learning, recurrent neural networks, convolutional neural networks and Transformers have been applied to fields including computer vision, speech recognition, natural language processing, machine translation, bioinformatics, drug design, medical image analysis, Climatology, climate science, material inspection and board game programs, where they have produced results comparable to and in some cases surpassing human expert performance. Artificial neural networks (ANNs) were inspired by information processing and distributed communication nodes in biological systems. ANNs have various differences from biological brains. Specifically, artificial ...
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Gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a basic unit of heredity and the molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protein-coding genes and noncoding genes. During gene expression, the DNA is first copied into RNA. The RNA can be directly functional or be the intermediate template for a protein that performs a function. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic traits. These genes make up different DNA sequences called genotypes. Genotypes along with environmental and developmental factors determine what the phenotypes will be. Most biological traits are under the influence of polygenes (many different genes) as well as gen ...
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