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Benzoyl-CoA
Benzoyl-CoA is a molecule implied in the activity of the different enzymes 4-hydroxybenzoyl-CoA reductase, benzoyl-CoA reductase, benzoyl-CoA 3-monooxygenase, benzoate-CoA ligase, 2alpha-hydroxytaxane 2-O-benzoyltransferase, anthranilate N-benzoyltransferase, biphenyl synthase, glycine N-benzoyltransferase, ornithine N-benzoyltransferase and phenylglyoxylate dehydrogenase (acylating). It is a substrate in the formation of xanthonoids in ''Hypericum androsaemum'' by benzophenone synthase, condensing a molecule of benzoyl-CoA with three malonyl-CoA, yielding to 2,4,6-trihydroxybenzophenone. This intermediate is subsequently converted by a benzophenone 3′-hydroxylase Benzophenone is the organic compound with the formula (C6H5)2CO, generally abbreviated Ph2CO. It is a white solid that is soluble in organic solvents. Benzophenone is a widely used building block in organic chemistry, being the parent diarylket ..., a cytochrome P450 monooxygenase, leading to the formation of ...
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4-hydroxybenzoyl-CoA Reductase
In enzymology, a 4-hydroxybenzoyl-CoA reductase () is an enzyme found in some bacteria and archaea that catalyzes the chemical reaction :benzoyl-CoA + acceptor + H2O \rightleftharpoons 4-hydroxybenzoyl-CoA + reduced acceptor The 3 substrates of this enzyme are benzoyl-CoA, acceptor, and H2O, whereas its two products are 4-hydroxybenzoyl-CoA and reduced acceptor. This enzyme participates in benzoate degradation via coa ligation. Nomenclature This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with other acceptors. The systematic name A systematic name is a name given in a systematic way to one unique group, organism, object or chemical substance, out of a specific population or collection. Systematic names are usually part of a nomenclature. A semisystematic name or semitrivial ... of this enzyme class is benzoyl-CoA:acceptor oxidoreductase. Other names in common use include: * 4-hydroxybenzoyl-CoA reductase (dehydroxy ...
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Benzoyl-CoA 3-monooxygenase
In enzymology, a benzoyl-CoA 3-monooxygenase () is an enzyme that catalyzes the chemical reaction: :benzoyl-CoA + NADPH + H+ + O2 \rightleftharpoons 3-hydroxybenzoyl-CoA + NADP+ + H2O The 4 substrates of this enzyme are benzoyl-CoA, NADPH, H+, and O2, whereas its 3 products are 3-hydroxybenzoyl-CoA, NADP+, and H2O. This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name A systematic name is a name given in a systematic way to one unique group, organism, object or chemical substance, out of a specific population or collection. Systematic names are usually part of a nomenclature. A semisystematic name or semitrivial ... of this enzyme class is benzoyl-CoA,NADPH:oxygen oxidoreductase (3-hydroxylating). This enzy ...
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2alpha-hydroxytaxane 2-O-benzoyltransferase
In enzymology, a 2alpha-hydroxytaxane 2-O-benzoyltransferase () is an enzyme that catalyzes the chemical reaction :benzoyl-CoA + 10-deacetyl-2-debenzoylbaccatin III \rightleftharpoons CoA + 10-deacetylbaccatin III Thus, the two substrates of this enzyme are benzoyl-CoA and 10-deacetyl-2-debenzoylbaccatin III, whereas its two products are CoA and 10-deacetylbaccatin III. This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name A systematic name is a name given in a systematic way to one unique group, organism, object or chemical substance, out of a specific population or collection. Systematic names are usually part of a nomenclature. A semisystematic name or semitrivial ... of this enzyme class is benzoyl-CoA:taxan-2alpha-ol O-benzoyltransferase. This enzyme is also called benzoyl-CoA:taxane 2alpha-O-benzoyltransferase. This enzyme participates in diterpenoid biosynthesis. Re ...
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Benzoyl-CoA Reductase
In enzymology, a benzoyl-CoA reductase () is an enzyme that catalyzes the chemical reaction :benzoyl-CoA + reduced acceptor + 2 ATP + 2 H2O \rightleftharpoons cyclohexa-1,5-diene-1-carbonyl-CoA + acceptor + 2 ADP + 2 phosphate The 4 substrates of this enzyme are benzoyl-CoA, reduced acceptor, ATP, and H2O, whereas its 4 products are cyclohexa-1,5-diene-1-carbonyl-CoA, acceptor, ADP, and phosphate. This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with other acceptors. The systematic name of this enzyme class is cyclohexa-1,5-diene-1-carbonyl-CoA:acceptor oxidoreductase (aromatizing, ATP-forming). This enzyme is also called benzoyl-CoA reductase (dearomatizing). This enzyme participates in benzoate degradation via CoA ligation. It has two cofactors: manganese, and magnesium Magnesium is a chemical element with the symbol Mg and atomic number 12. It is a shiny gray metal having a low density, low mel ...
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Anthranilate N-benzoyltransferase
In enzymology, an anthranilate N-benzoyltransferase () is an enzyme that catalyzes the chemical reaction :benzoyl-CoA + anthranilate \rightleftharpoons CoA + N-benzoylanthranilate Thus, the two substrates of this enzyme are benzoyl-CoA and anthranilate, whereas its two products are CoA and N-benzoylanthranilate. This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name A systematic name is a name given in a systematic way to one unique group, organism, object or chemical substance, out of a specific population or collection. Systematic names are usually part of a nomenclature. A semisystematic name or semitrivial ... of this enzyme class is benzoyl-CoA:anthranilate N-benzoyltransferase. References * EC 2.3.1 Enzymes of unknown structure Anthranilates {{2.3-enzyme-stub ...
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Glycine N-benzoyltransferase
In enzymology, a glycine N-benzoyltransferase () is an enzyme that catalyzes the chemical reaction :benzoyl-CoA + glycine \rightleftharpoons CoA + N-benzoylglycine Thus, the two substrates of this enzyme are benzoyl-CoA and glycine, whereas its two products are CoA and N-benzoylglycine. This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is benzoyl-CoA:glycine N-benzoyltransferase. Other names in common use include benzoyl CoA-amino acid N-acyltransferase, and benzoyl-CoA:glycine N-acyltransferase. This enzyme participates in phenylalanine metabolism Phenylalanine (symbol Phe or F) is an essential α-amino acid with the formula . It can be viewed as a benzyl group substituted for the methyl group of alanine, or a phenyl group in place of a terminal hydrogen of alanine. This essential amino ac .... References * EC 2.3.1 Enzymes of unknown st ...
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Biphenyl Synthase
In enzymology, a biphenyl synthase () is an enzyme that catalyzes the chemical reaction: :3 malonyl-CoA + benzoyl-CoA \rightleftharpoons 4 CoA + 3,5-dihydroxybiphenyl + 4 CO2 Thus, the two substrates of this enzyme are malonyl-CoA and benzoyl-CoA, whereas its three products are CoA, 3,5-dihydroxybiphenyl, and CO2. This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name A systematic name is a name given in a systematic way to one unique group, organism, object or chemical substance, out of a specific population or collection. Systematic names are usually part of a nomenclature. A semisystematic name or semitrivial ... of this enzyme class is malonyl-CoA:benzoyl-CoA malonyltransferase. This enzyme is also called BIS. References * EC 2.3.1 {{2.3-enzyme-stub ...
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Ornithine N-benzoyltransferase
In enzymology, an ornithine N-benzoyltransferase () is an enzyme that catalyzes the chemical reaction :2 benzoyl-CoA + L-ornithine \rightleftharpoons 2 CoA + N2,N5-dibenzoyl-L-ornithine Thus, the two substrates of this enzyme are benzoyl-CoA and L-ornithine, whereas its two products are CoA and N2,N5-dibenzoyl-L-ornithine. This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name A systematic name is a name given in a systematic way to one unique group, organism, object or chemical substance, out of a specific population or collection. Systematic names are usually part of a nomenclature. A semisystematic name or semitrivial ... of this enzyme class is benzoyl-CoA:L-ornithine N-benzoyltransferase. This enzyme is also called ornithine N-acyltransferase. References * EC 2.3.1 Enzymes of unknown structure {{2.3-enzyme-stub ...
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Benzophenone Synthase
In enzymology, a benzophenone synthase () is an enzyme that catalyzes the chemical reaction :3 malonyl-CoA + 3-hydroxybenzoyl-CoA \rightleftharpoons 4 CoA + 2,3',4,6-tetrahydroxybenzophenone + 3 CO2 Thus, the two substrates of this enzyme are malonyl-CoA and 3-hydroxybenzoyl-CoA, whereas its 3 products are CoA, 2,3',4,6-tetrahydroxybenzophenone, and CO2. This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name A systematic name is a name given in a systematic way to one unique group, organism, object or chemical substance, out of a specific population or collection. Systematic names are usually part of a nomenclature. A semisystematic name or semitrivial ... of this enzyme class is malonyl-CoA:3-hydroxybenzoyl-CoA malonyltransferase. References * EC 2.3.1 Enzymes of unknown structure {{2.3-enzyme-stub ...
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Xanthonoid
A xanthonoid is a chemical natural phenolic compound formed from the xanthone backbone. Many members of the Clusiaceae contain xanthonoids. Xanthonoid biosynthesis in cell cultures of ''Hypericum androsaemum'' involves the presence of a benzophenone synthase condensing a molecule of benzoyl-CoA with three malonyl-CoA yielding to 2,4,6-trihydroxybenzophenone. This intermediate is subsequently converted by a benzophenone 3′-hydroxylase, a cytochrome P450 monooxygenase, leading to the formation of 2,3′,4,6-tetrahydroxybenzophenone. Some examples are tomentonone, zeyloxanthonone and calozeyloxanthone isolated from the bark of ''Calophyllum tomentosum'', apetalinone A, B, C and D from '' Calophyllum apetalum'', gaudichaudione A, B, C, D, E, F, G, H, gaudichaudiic acid A, B, C, D, E, morellic acid and forbesione from '' Garcinia gaudichaudii'', methylswertianin and bellidifolin from '' Swertia punicea'' or psorospermin obtained from '' Psorospermum febrifu ...
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Hypericum Androsaemum
''Hypericum androsaemum'', also referred to as Tutsan, Shrubby St. John's Wort, or sweet-amber, is a flowering plant in the family Hypericaceae. It is a perennial shrub reaching up to 70 cm in height, native to open woods and hillsides in Eurasia. Common name Tutsan comes from the French toute-sain meaning all heal due to its medicinal uses. This berry producing shrub is common in the Mediterranean basin where it has been traditionally used as diuretic and hepatoprotective herb. In the Portuguese ethno-medicine, the plant is locally known as ‘Hipericão do Gerês’ and it used as diuretic, hepato protective and antidepressant. In Spain, the infusion of the flowering aerial parts is used as an antidepressive and anxiolytic. In England, tutsan ointment is used to dress cuts and wounds. The berries turn from white/green, to red, to black. According to Shepherd (2004) all parts of the plant, particularly the fruit, are toxic due to the presence of hypericin, causing nausea and ...
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Benzophenone 3′-hydroxylase
Benzophenone is the organic compound with the formula (C6H5)2CO, generally abbreviated Ph2CO. It is a white solid that is soluble in organic solvents. Benzophenone is a widely used building block in organic chemistry, being the parent diarylketone. Uses Benzophenone can be used as a photo initiator in UV(Ultra-violet)-curing applications such as inks, imaging, and clear coatings in the printing industry. Benzophenone prevents ultraviolet ( UV) light from damaging scents and colors in products such as perfumes and soaps. Benzophenone can also be added to plastic packaging as a UV blocker to prevent photo-degradation of the packaging polymers or its contents. Its use allows manufacturers to package the product in clear glass or plastic (such as a PETE water bottle). Without it, opaque or dark packaging would be required. In biological applications, benzophenones have been used extensively as photophysical probes to identify and map peptide–protein interactions. Benzophenone ...
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