Benzoyl-CoA is a molecule implied in the activity of the different enzymes 4-hydroxybenzoyl-CoA reductase,

benzoyl-CoA reductase In enzymology, a benzoyl-CoA reductase () is an enzyme that catalyzes the chemical reaction :benzoyl-CoA + reduced acceptor + 2 ATP + 2 H2O \rightleftharpoons cyclohexa-1,5-diene-1-carbonyl-CoA + acceptor + 2 ADP + 2 phosphate The 4 substrates ...

benzoyl-CoA 3-monooxygenase In enzymology, a benzoyl-CoA 3-monooxygenase () is an enzyme that catalyzes the chemical reaction: :benzoyl-CoA + NADPH + H+ + O2 \rightleftharpoons 3-hydroxybenzoyl-CoA + NADP+ + H2O The 4 substrates of this enzyme are benzoyl-CoA, NADPH, H+ ...

, benzoate-CoA ligase, 2alpha-hydroxytaxane 2-O-benzoyltransferase,

anthranilate N-benzoyltransferase In enzymology, an anthranilate N-benzoyltransferase () is an enzyme that catalyzes the chemical reaction :benzoyl-CoA + anthranilate \rightleftharpoons CoA + N-benzoylanthranilate Thus, the two substrates of this enzyme are benzoyl-CoA and anth ...

biphenyl synthase In enzymology, a biphenyl synthase () is an enzyme that catalyzes the chemical reaction: :3 malonyl-CoA + benzoyl-CoA \rightleftharpoons 4 CoA + 3,5-dihydroxybiphenyl + 4 CO2 Thus, the two substrates of this enzyme are malonyl-CoA and benzoyl- ...

glycine N-benzoyltransferase In enzymology, a glycine N-benzoyltransferase () is an enzyme that catalyzes the chemical reaction :benzoyl-CoA + glycine \rightleftharpoons CoA + N-benzoylglycine Thus, the two substrates of this enzyme are benzoyl-CoA and glycine, whereas its ...

ornithine N-benzoyltransferase In enzymology, an ornithine N-benzoyltransferase () is an enzyme that catalyzes the chemical reaction :2 benzoyl-CoA + L-ornithine \rightleftharpoons 2 CoA + N2,N5-dibenzoyl-L-ornithine Thus, the two substrates of this enzyme are benzoyl-CoA an ...

and phenylglyoxylate dehydrogenase (acylating). It is a substrate in the formation of

xanthonoid A xanthonoid is a chemical natural phenolic compound formed from the xanthone backbone. Many members of the Clusiaceae contain xanthonoids. Xanthonoid biosynthesis in cell cultures of '' Hypericum androsaemum'' involves the presence of a benzoph ...

s in ''

Hypericum androsaemum ''Hypericum androsaemum'', also referred to as Tutsan, Shrubby St. John's Wort, or sweet-amber, is a flowering plant in the family Hypericaceae. It is a perennial shrub reaching up to 70 cm in height, native to open woods and hillsides in E ...

'' by

benzophenone synthase In enzymology, a benzophenone synthase () is an enzyme that catalyzes the chemical reaction :3 malonyl-CoA + 3-hydroxybenzoyl-CoA \rightleftharpoons 4 CoA + 2,3',4,6-tetrahydroxybenzophenone + 3 CO2 Thus, the two substrates of this enzyme are m ...

, condensing a molecule of benzoyl-CoA with three

malonyl-CoA Malonyl-CoA is a coenzyme A derivative of malonic acid. Functions It plays a key role in chain elongation in fatty acid biosynthesis and polyketide biosynthesis. Fatty acid biosynthesis Malonyl-CoA provides 2-carbon units to fatty acids and commi ...

, yielding to 2,4,6-trihydroxybenzophenone. This intermediate is subsequently converted by a

benzophenone 3′-hydroxylase Benzophenone is the organic compound with the formula (C6H5)2CO, generally abbreviated Ph2CO. It is a white solid that is soluble in organic solvents. Benzophenone is a widely used building block in organic chemistry, being the parent diarylket ...

, a cytochrome P450 monooxygenase, leading to the formation of 2,3′,4,6-tetrahydroxybenzophenone. Benzoyl-CoA is a substrate of benzoyl-CoA reductase. This enzyme is responsible in part for the reductive dearomatization of aryl compounds mediated by bacteria under anaerobic conditions.Matthias Boll , Georg Fuchs , Johann Heider "Anaerobic oxidation of aromatic compounds and hydrocarbons" Current Opinion in Chemical Biology 2002 Volume 6, pp. 604–611.

References

{{reflist Thioesters of coenzyme A