Actinobacillus Infections
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Actinobacillus Infections
''Actinobacillus'' is a genus of Gram-negative, nonmotile and non-spore-forming, oval to rod-shaped bacteria occurring as parasites or pathogens in mammals, birds, and reptiles. It is a member of the family Pasteurellaceae. The bacteria are facultatively anaerobic or aerobic, capable of fermenting carbohydrates (without production of gas), and of reducing nitrates. The genomic DNA contains between 40 and 47 mol % guanine plus cytosine. ''Actinobacillus'' ('' Pasteurella'') ''ureae'' and ''A. hominis'' occur in the respiratory tracts of healthy humans and may be involved in the pathogenesis of sinusitis, bronchopneumonia, and meningitis. ''A. actinomycetemcomitans'' occurs in the human oral microflora, and together with anaerobic or capnophilic organisms (HACEK group organisms) may cause endocarditis. Actinobacilli are susceptible to most antibiotics of the beta-lactam family, aminoglycosides, tetracyclines, chloramphenicol, and many other antibacterial chemotherapeuti ...
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Actinobacillus Actinomycetemcomitans
''Aggregatibacter actinomycetemcomitans'' is a Gram-negative, facultative anaerobe, nonmotile bacterium that is often found in association with localized aggressive periodontitis, a severe infection of the periodontium. It is also suspected to be involved in chronic periodontitis. Less frequently, ''A. actinomycetemcomitans'' is associated with nonoral infections such as endocarditis. Its role in aggressive periodontitis was first discovered by Danish-born periodontist Jørgen Slots, a professor of dentistry and microbiology at the University of Southern California School of Dentistry. 'Bacterium actinomycetem comitans' was first described by Klinger (1912) as coccobacillary bacteria isolated with ''Actinomyces'' from actinomycotic lesions in humans. It was reclassified as ''Actinobacillus actinomycetemcomitans'' by Topley & Wilson (1929) and as ''Haemophilus actinomycetemcomitans'' by Potts ''et al.'' (1985). The species has attracted attention because of its association ...
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Actinobacillus Ureae
''Actinobacillus'' is a genus of Gram-negative, nonmotile and non-spore-forming, oval to rod-shaped bacteria occurring as parasites or pathogens in mammals, birds, and reptiles. It is a member of the family Pasteurellaceae. The bacteria are facultatively anaerobic or aerobic, capable of fermenting carbohydrates (without production of gas), and of reducing nitrates. The genomic DNA contains between 40 and 47 mol % guanine plus cytosine. ''Actinobacillus'' ('' Pasteurella'') ''ureae'' and ''A. hominis'' occur in the respiratory tracts of healthy humans and may be involved in the pathogenesis of sinusitis, bronchopneumonia, and meningitis. ''A. actinomycetemcomitans'' occurs in the human oral microflora, and together with anaerobic or capnophilic organisms ( HACEK group organisms) may cause endocarditis. Actinobacilli are susceptible to most antibiotics of the beta-lactam family, aminoglycosides, tetracyclines, chloramphenicol, and many other antibacterial chemotherapeut ...
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Aggregatibacter
''Aggregatibacter'' is a genus in the phylum Pseudomonadota (Bacteria), which contains three species, namely: * '' A. actinomycetemcomitans'' (Klinger 1912) Nørskov-Lauritsen and Kilian 2006, (type species of the genus); (from Greek noun (ἀκτίς, ἀκτῖνος), a beam; Greek ''mukēs -ētos'', mushroom or other fungus; New Latin ''actinomyces'' -''etis'', an actinomycete; Latin ''comitans'', accompanying; New Latin ''actinomycetemcomitans'', accompanying an actinomycete) * '' A. aphrophilus'' (Khairat 1940) Nørskov-Lauritsen and Kilian 2006, (from Ancient Greek , foam; New Latin from Greek (φίλος) meaning friend, loving; New Latin ''aphrophilus'', foam-loving) * '' A. segnis'' (Kilian 1977) Nørskov-Lauritsen and Kilian 2006, (from Latin ''segnis'', slow, sluggish, inactive) See also * Bacterial taxonomy * Microbiology Microbiology () is the scientific study of microorganisms, those being unicellular (single cell), multicellular (cell colony), or acellular ...
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Monophyly
In cladistics for a group of organisms, monophyly is the condition of being a clade—that is, a group of taxa composed only of a common ancestor (or more precisely an ancestral population) and all of its lineal descendants. Monophyletic groups are typically characterised by shared derived characteristics ( synapomorphies), which distinguish organisms in the clade from other organisms. An equivalent term is holophyly. The word "mono-phyly" means "one-tribe" in Greek. Monophyly is contrasted with paraphyly and polyphyly as shown in the second diagram. A ''paraphyletic group'' consists of all of the descendants of a common ancestor minus one or more monophyletic groups. A '' polyphyletic group'' is characterized by convergent features or habits of scientific interest (for example, night-active primates, fruit trees, aquatic insects). The features by which a polyphyletic group is differentiated from others are not inherited from a common ancestor. These definitions have taken ...
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Chemotherapeutic
Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx) is a type of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents or alkylating agents) as part of a standardized chemotherapy regimen. Chemotherapy may be given with a curative intent (which almost always involves combinations of drugs) or it may aim to prolong life or to reduce symptoms (palliative chemotherapy). Chemotherapy is one of the major categories of the medical discipline specifically devoted to pharmacotherapy for cancer, which is called ''medical oncology''. The term ''chemotherapy'' has come to connote non-specific usage of intracellular poisons to inhibit mitosis (cell division) or induce DNA damage, which is why inhibition of DNA repair can augment chemotherapy. The connotation of the word chemotherapy excludes more selective agents that block extracellular signals (signal transduction). The development of therapies with specific molecular or genetic targets, whic ...
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Chloramphenicol
Chloramphenicol is an antibiotic useful for the treatment of a number of bacterial infections. This includes use as an eye ointment to treat conjunctivitis. By mouth or by injection into a vein, it is used to treat meningitis, plague, cholera, and typhoid fever. Its use by mouth or by injection is only recommended when safer antibiotics cannot be used. Monitoring both blood levels of the medication and blood cell levels every two days is recommended during treatment. Common side effects include bone marrow suppression, nausea, and diarrhea. The bone marrow suppression may result in death. To reduce the risk of side effects treatment duration should be as short as possible. People with liver or kidney problems may need lower doses. In young children a condition known as gray baby syndrome may occur which results in a swollen stomach and low blood pressure. Its use near the end of pregnancy and during breastfeeding is typically not recommended. Chloramphenicol is a broad-spectrum ...
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Tetracycline
Tetracycline, sold under various brand names, is an oral antibiotic in the tetracyclines family of medications, used to treat a number of infections, including Acne vulgaris, acne, cholera, brucellosis, plague (disease), plague, malaria, and syphilis. Common side effects include vomiting, diarrhea, rash, and loss of appetite. Other side effects include poor tooth development if used by children less than eight years of age, kidney problems, and sunburning easily. Use during pregnancy may harm the baby. It works by inhibiting protein synthesis in bacteria. Tetracycline was patented in 1953 and came into commercial use in 1978. It is on the World Health Organization's List of Essential Medicines. Tetracycline is available as a generic medication. Tetracycline was originally made from bacteria of the genus ''Streptomyces''. Medical uses Spectrum of activity Tetracyclines have a broad spectrum of antibiotic action. Originally, they possessed some level of bacteriostatic acti ...
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Aminoglycoside
Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside (sugar). The term can also refer more generally to any organic molecule that contains amino sugar substructures. Aminoglycoside antibiotics display bactericidal activity against Gram-negative aerobes and some anaerobic bacilli where resistance has not yet arisen but generally not against Gram-positive and anaerobic Gram-negative bacteria.ME Levison, MD, 2012, Aminoglycosides, The Merck Manua accessed 22 February 2014. Streptomycin is the first-in-class aminoglycoside antibiotic. It is derived from ''Streptomyces griseus'' and is the earliest modern agent used against tuberculosis. Streptomycin lacks the common 2-deoxystreptamine moiety (image right, below) present in most other members of this class. Other examples of aminoglycosides include the deoxystreptamine-containi ...
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HACEK
The HACEK organisms are a group of fastidious Gram-negative bacteria that are an unusual cause of infective endocarditis, which is an inflammation of the heart due to bacterial infection. HACEK is an abbreviation of the initials of the genera of this group of bacteria: '' Haemophilus'', '' Aggregatibacter'' (previously ''Actinobacillus''), ''Cardiobacterium'', '' Eikenella'', '' Kingella''. The HACEK organisms are a normal part of the human microbiota, living in the oral- pharyngeal region. The bacteria were originally grouped because they were thought to be a significant cause of infective endocarditis, but recent research has shown that they are rare and only responsible for 1.4–3.0% of all cases of this disease. Organisms HACEK originally referred to ''Haemophilus parainfluenzae'', ''Haemophilus aphrophilus'', ''Actinobacillus actinomycetemcomitans'', ''Cardiobacterium hominis'', '' Eikenella corrodens'', and '' Kingella kingae''. However, taxonomic rearrangements have c ...
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Oral Microbiology
Oral microbiology is the study of the microorganisms (microbiota) of the oral cavity and their interactions between oral microorganisms or with the host. The environment present in the human mouth is suited to the growth of characteristic microorganisms found there. It provides a source of water and nutrients, as well as a moderate temperature. Resident microbes of the mouth adhere to the teeth and gums to resist mechanical flushing from the mouth to stomach where acid-sensitive microbes are destroyed by hydrochloric acid. Anaerobic bacteria in the oral cavity include: ''Actinomyces'', '' Arachnia'' ('' Propionibacterium propionicus''), ''Bacteroides'', ''Bifidobacterium'', '' Eubacterium'', ''Fusobacterium'', ''Lactobacillus'', '' Leptotrichia'', '' Peptococcus'', ''Peptostreptococcus'', ''Propionibacterium'', ''Selenomonas'', ''Treponema'', and ''Veillonella''. Genera of fungi that are frequently found in the mouth include '' Candida'', ''Cladosporium'', ''Aspergillus'', ''Fu ...
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Bronchopneumonia
Bronchopneumonia is a subtype of pneumonia. It is the acute inflammation of the bronchi, accompanied by inflamed patches in the nearby lobules of the lungs. citing: Webster's New World College Dictionary, Fifth Edition, Copyright 2014 It is often contrasted with lobar pneumonia; but, in clinical practice, the types are difficult to apply, as the patterns usually overlap. Topic Completed: 1 August 2011 Bronchopneumonia (lobular) often leads to lobar pneumonia as the infection progresses. The same organism may cause one type of pneumonia in one patient, and another in a different patient. Causes Bronchopneumonia is usually a bacterial pneumonia rather than being caused by viral disease. Medically reviewed by Gerhard Whitworth, RN, on April 19, 2019 It is more commonly a hospital-acquired pneumonia than a community-acquired pneumonia, in contrast to lobar pneumonia. Bronchopneumonia is less likely than lobar pneumonia to be associated with ''Streptococcus pneumoniae''. Rather, t ...
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Sinusitis
Sinusitis, also known as rhinosinusitis, is inflammation of the nasal mucosa, mucous membranes that line the paranasal sinuses, sinuses resulting in symptoms that may include thick Mucus#Respiratory system, nasal mucus, a nasal congestion, plugged nose, and Orofacial pain, facial pain. Other signs and symptoms may include fever, headaches, a hyposmia, poor sense of smell, sore throat, a feeling that phlegm is oozing out from the back of the nose to the throat along with a necessity to clear the throat frequently and frequent attacks of cough. Generally sinusitis starts off as a common viral infection like common cold. This infection generally subsides within 5 to 7 days. During this time the nasal structures can swell and facilitate the stagnation of fluids in sinuses that leads to acute (medicine), acute sinusitis which lasts from 6th day of the infection to 15th day. From the 15th day to 45th day of the infection comes the subacute stage followed by chronic (medicine), chronic ...
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