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Acetone–butanol–ethanol Fermentation
Acetone–butanol–ethanol (ABE) fermentation, also known as the Weizmann process, is a process that uses bacterial fermentation to produce acetone, n-butanol, and ethanol from carbohydrates such as starch and glucose. It was developed by chemist Chaim Weizmann and was the primary process used to produce acetone, which was needed to make cordite, a substance essential for the British war industry during World War I. Process The process may be likened to how yeast ferments sugars to produce ethanol for wine, beer, or fuel, but the organisms that carry out the ABE fermentation are strictly anaerobic (obligate anaerobes). The ABE fermentation produces solvents in a ratio of 3 parts acetone, 6 parts butanol to 1 part ethanol. It usually uses a strain of bacteria from the Class Clostridia (Family Clostridiaceae). ''Clostridium acetobutylicum'' is the most well-studied and widely used. Although less effective, ''Clostridium beijerinckii'' and ''Clostridium saccharobutylicum'' bacteria ...
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Acetone–butanol–ethanol Fermentation
Acetone–butanol–ethanol (ABE) fermentation, also known as the Weizmann process, is a process that uses bacterial fermentation to produce acetone, n-butanol, and ethanol from carbohydrates such as starch and glucose. It was developed by chemist Chaim Weizmann and was the primary process used to produce acetone, which was needed to make cordite, a substance essential for the British war industry during World War I. Process The process may be likened to how yeast ferments sugars to produce ethanol for wine, beer, or fuel, but the organisms that carry out the ABE fermentation are strictly anaerobic (obligate anaerobes). The ABE fermentation produces solvents in a ratio of 3 parts acetone, 6 parts butanol to 1 part ethanol. It usually uses a strain of bacteria from the Class Clostridia (Family Clostridiaceae). ''Clostridium acetobutylicum'' is the most well-studied and widely used. Although less effective, ''Clostridium beijerinckii'' and ''Clostridium saccharobutylicum'' bacteria ...
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Clostridium Saccharobutylicum
''Clostridium saccharobutylicum'' is an indole and notably acetone, butanol and ethanol-producing bacterium, with type strain DSM DSM or dsm may refer to: Science and technology * Deep space maneuver * Design structure matrix or dependency structure matrix, a representation of a system or project * Diagnostic and Statistical Manual of Mental Disorders ** DSM-5, the fifth ed ... 13864T (= ATCC BAA-117T). Its genome has been sequenced. References Further reading * * Law, Laurent. Production of biobutanol from white grape pomace by Clostridium saccharobutylicum using submerged fermentation. Diss. AUT University, 2010. External links * LPSNType strain of ''Clostridium saccharobutylicum'' at Bac''Dive'' - the Bacterial Diversity Metadatabase Gram-positive bacteria Bacteria described in 2001 saccharobutylicum {{Clostridia-stub ...
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Liverpool, England
Liverpool is a city and metropolitan borough in Merseyside, England. With a population of in 2019, it is the 10th largest English district by population and its metropolitan area is the fifth largest in the United Kingdom, with a population of 2.24 million. On the eastern side of the Mersey Estuary, Liverpool historically lay within the ancient hundred of West Derby in the county of Lancashire. It became a borough in 1207, a city in 1880, and a county borough independent of the newly-created Lancashire County Council in 1889. Its growth as a major port was paralleled by the expansion of the city throughout the Industrial Revolution. Along with general cargo, freight, and raw materials such as coal and cotton, merchants were involved in the slave trade. In the 19th century, Liverpool was a major port of departure for English and Irish emigrants to North America. It was also home to both the Cunard and White Star Lines, and was the port of registry of the ocean lin ...
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Peoria, IL
Peoria ( ) is the county seat of Peoria County, Illinois, United States, and the largest city on the Illinois River. As of the 2020 census, the city had a population of 113,150. It is the principal city of the Peoria Metropolitan Area in Central Illinois, consisting of the counties of Fulton, Marshall, Peoria, Stark, Tazewell, and Woodford, which had a population of 402,391 in 2020. Established in 1691 by the French explorer Henri de Tonti, Peoria is the oldest permanent European settlement in Illinois according to the Illinois State Archaeological Survey. Originally known as Fort Clark, it received its current name when the County of Peoria organized in 1825. The city was named after the Peoria tribe, a member of the Illinois Confederation. On October 16, 1854, Abraham Lincoln made his Peoria speech against the Kansas-Nebraska Act. Prior to prohibition, Peoria was the center of the whiskey industry in the United States. More than 12 distilleries operated in Peoria by th ...
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Terre Haute, IN
Terre Haute ( ) is a city in and the county seat of Vigo County, Indiana, United States, about 5 miles east of the state's western border with Illinois. As of the 2010 census, the city had a population of 60,785 and its metropolitan area had a population of 170,943. Located along the Wabash River, Terre Haute is one of the largest cities in the Wabash Valley and is known as the Queen City of the Wabash. The city is home to multiple higher-education institutions, including Indiana State University, Rose-Hulman Institute of Technology, and Ivy Tech Community College of Indiana. History Terre Haute's name is derived from the French phrase ''terre haute'' (pronounced in French), meaning "highland". It was named by French-Canadian explorers and fur trappers to the area in the early 18th century to describe the unique location above the Wabash River (see French colonization of the Americas). At the time, the area was claimed by the French and British and these highlands were consi ...
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Commercial Solvents Corporation
Commercial Solvents Corporation (CSC) was an American chemical and biotechnology company created in 1919. History The Commercial Solvents Corporation was established at the end of World War I; earning distinction as the pioneer producer of acetone and butanol by fermentation processes developed and patented by Dr. Chaim Weizmann. Terre Haute, Indiana was chosen to be the site of CSC's research as this location made possible the expedient translation of new processes from the laboratory and demonstration plant into full production. As early as 1917, the corporation began work in Terre Haute, Indiana. It developed the conversion of corn and other grains into ethanol Ethanol (abbr. EtOH; also called ethyl alcohol, grain alcohol, drinking alcohol, or simply alcohol) is an organic compound. It is an alcohol with the chemical formula . Its formula can be also written as or (an ethyl group linked to a ... by fermentation. They later produced riboflavin by microbial acti ...
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Auguste Fernbach
Auguste Fernbach (2 March 1860 – 26 January 1939) was a French biologist A biologist is a scientist who conducts research in biology. Biologists are interested in studying life on Earth, whether it is an individual Cell (biology), cell, a multicellular organism, or a Community (ecology), community of Biological inter .... Life Fernbach worked as a biologist in France. The Fernbach flask is named after him. References External links * Pasteur Institute:Auguste Fernbach French biologists 1860 births 1939 deaths {{France-biologist-stub ...
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Louis Pasteur
Louis Pasteur (, ; 27 December 1822 – 28 September 1895) was a French chemist and microbiologist renowned for his discoveries of the principles of vaccination, microbial fermentation and pasteurization, the latter of which was named after him. His research in chemistry led to remarkable breakthroughs in the understanding of the causes and preventions of diseases, which laid down the foundations of hygiene, public health and much of modern medicine. His works are credited to saving millions of lives through the developments of vaccines for rabies and anthrax. He is regarded as one of the founders of modern bacteriology and has been honored as the "father of bacteriology" and the "father of microbiology" (together with Robert Koch; the latter epithet also attributed to Antonie van Leeuwenhoek). Pasteur was responsible for disproving the doctrine of spontaneous generation. Under the auspices of the French Academy of Sciences, his experiment demonstrated that in sterilized ...
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Butanol
Butanol (also called butyl alcohol) is a four-carbon alcohol with a formula of C4 H9 O H, which occurs in five isomeric structures (four structural isomers), from a straight-chain primary alcohol to a branched-chain tertiary alcohol; all are a butyl or isobutyl group linked to a hydroxyl group (sometimes represented as BuOH, ''n''-BuOH, ''i''-BuOH, and ''t''-BuOH). These are ''n''-butanol, 2 stereoisomers of sec-butanol, isobutanol and ''tert''-butanol. Butanol is primarily used as a solvent and as an intermediate in chemical synthesis, and may be used as a fuel. Biologically produced butanol is called biobutanol, which may be ''n''-butanol or isobutanol. Isomers The unmodified term ''butanol'' usually refers to the straight chain isomer with the alcohol functional group at the terminal carbon, which is also known as ''n''-butanol or 1-butanol. The straight chain isomer with the alcohol at an internal carbon is ''sec''-butanol or 2-butanol. The branched isomer with the a ...
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Hydrogen
Hydrogen is the chemical element with the symbol H and atomic number 1. Hydrogen is the lightest element. At standard conditions hydrogen is a gas of diatomic molecules having the formula . It is colorless, odorless, tasteless, non-toxic, and highly combustible. Hydrogen is the most abundant chemical substance in the universe, constituting roughly 75% of all normal matter.However, most of the universe's mass is not in the form of baryons or chemical elements. See dark matter and dark energy. Stars such as the Sun are mainly composed of hydrogen in the plasma state. Most of the hydrogen on Earth exists in molecular forms such as water and organic compounds. For the most common isotope of hydrogen (symbol 1H) each atom has one proton, one electron, and no neutrons. In the early universe, the formation of protons, the nuclei of hydrogen, occurred during the first second after the Big Bang. The emergence of neutral hydrogen atoms throughout the universe occurred about 370,000 ...
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Carbon Dioxide
Carbon dioxide (chemical formula ) is a chemical compound made up of molecules that each have one carbon atom covalently double bonded to two oxygen atoms. It is found in the gas state at room temperature. In the air, carbon dioxide is transparent to visible light but absorbs infrared radiation, acting as a greenhouse gas. It is a trace gas in Earth's atmosphere at 421 parts per million (ppm), or about 0.04% by volume (as of May 2022), having risen from pre-industrial levels of 280 ppm. Burning fossil fuels is the primary cause of these increased CO2 concentrations and also the primary cause of climate change.IPCC (2022Summary for policy makersiClimate Change 2022: Mitigation of Climate Change. Contribution of Working Group III to the Sixth Assessment Report of the Intergovernmental Panel on Climate Change Cambridge University Press, Cambridge, United Kingdom and New York, NY, USA Carbon dioxide is soluble in water and is found in groundwater, lakes, ice caps, ...
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Solventogenesis
Solventogenesis is the biochemical production of solvents (usually acetone and butanol) by ''Clostridium'' species.Peter Dürre, Systems Biology of Clostridium, 2014 It is the second phase of ABE fermentation. Jones and Woods, Acetone-Butanol Fermentation Revisited, Microbiological Reviews (1986), https://mmbr.asm.org/content/mmbr/50/4/484.full.pdf Process Solventogenic ''Clostridium'' species have a biphasic metabolism composed of an acidogenic phase and a solventogenic phase. During acidogenesis, these bacteria are able to convert several carbon sources into organic acids, commonly butyrate and acetate. As acid accumulates, cells begin to assimilate the organic acids to solvents. In ''Clostridium acetobutylicum'', a model solventogenic ''Clostridium'' species, a combination of low pH and high undisociated butyrate, referred to as the "pH-acid effect", triggers the metabolic shift from acidogenesis to solventogenesis. Hüsemann et al, Solventogenesis in ''Clostridium acetobut ...
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