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Zanthoxylum Dipetalum
''Zanthoxylum dipetalum'' is a rare species of tree in the family Rutaceae and in the same genus as Sichuan pepper. It is known by the Hawaiian names ''Kāwa'u'' and ''Heaʻe'' and is endemic to the Hawaiian archipelago, where it grows in forests on 3 or 4 of the islands.''Zanthoxylum dipetalum''.
The Nature Conservancy.
There are two . *''Z. d.'' var. ''dipetalum'' is present on , in the mountains of

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Tree
In botany, a tree is a perennial plant with an elongated stem, or trunk, usually supporting branches and leaves. In some usages, the definition of a tree may be narrower, including only woody plants with secondary growth, plants that are usable as lumber or plants above a specified height. In wider definitions, the taller palms, tree ferns, bananas, and bamboos are also trees. Trees are not a taxonomic group but include a variety of plant species that have independently evolved a trunk and branches as a way to tower above other plants to compete for sunlight. The majority of tree species are angiosperms or hardwoods; of the rest, many are gymnosperms or softwoods. Trees tend to be long-lived, some reaching several thousand years old. Trees have been in existence for 370 million years. It is estimated that there are some three trillion mature trees in the world. A tree typically has many secondary branches supported clear of the ground by the trunk. This trunk typically ...
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Chelerythrine
Chelerythrine is a benzophenanthridine alkaloid present in the plant ''Chelidonium majus'' (greater celandine). It is a potent, selective, and cell-permeable protein kinase C inhibitor ''in vitro''. And an efficacious antagonist of G-protein-coupled CB1 receptors. This molecule also exhibits anticancer qualities and it has served as a base for many potential novel drugs against cancer. Structurally, this molecule has two distinct conformations, one being a positively charged iminium form, and the other being an uncharged form, a pseudo-base. It is also found in the plants ''Zanthoxylum clava-herculis'' and '' Zanthoxylum rhoifolium'', exhibiting antibacterial activity against ''Staphylococcus aureus'' and other human pathogens. Research Antibacterial agent Chelerythrine is a potent antibacterial agent that has aided in dealing with the emergence of antibacterial resistant bacteria. This molecule has the ability to disrupt a bacteria's cell wall and cell membrane, as well a ...
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Endemic Flora Of Hawaii
Endemism is the state of a species being found in a single defined geographic location, such as an island, state, nation, country or other defined zone; organisms that are indigenous to a place are not endemic to it if they are also found elsewhere. For example, the Cape sugarbird is found exclusively in southwestern South Africa and is therefore said to be ''endemic'' to that particular part of the world. An endemic species can be also be referred to as an ''endemism'' or in scientific literature as an ''endemite''. For example '' Cytisus aeolicus'' is an endemite of the Italian flora. '' Adzharia renschi'' was once believed to be an endemite of the Caucasus, but it was later discovered to be a non-indigenous species from South America belonging to a different genus. The extreme opposite of an endemic species is one with a cosmopolitan distribution, having a global or widespread range. A rare alternative term for a species that is endemic is "precinctive", which applies to s ...
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Zanthoxylum
''Zanthoxylum'' is a genus of about 250 species of deciduous and evergreen trees, shrubs and climbers in the family Rutaceae that are native to warm temperate and subtropical areas worldwide. It is the type genus of the tribe Zanthoxyleae in the subfamily Rutoideae. Several of the species have yellow heartwood, to which their generic name alludes. Description Plants in the genus ''Zanthoxylum'' are typically dioecious shrubs, trees or woody climbers armed with trichomes. The leaves are arranged alternately and are usually pinnate or trifoliate. The flowers are usually arranged in panicles and usually function as male or female flowers with four sepals and four petals, the sepals remaining attached to the fruit. Male flowers have four stamens opposite the sepals. Female flowers have up to five, more or less free carpels with the styles free or sometimes fused near the tip. The fruit is usually of up to four follicles fused at the base, each containing a single seed almost a ...
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Magnoflorine
''(S)-''Magnoflorine is a quaternary benzylisoquinoline alkaloid (BIA) of the aporphine structural subgroup which has been isolated from various species of the family Menispermaceae, such as ''Pachygone ovata,'' '' Sinomenium acutum,'' and ''Cissampelos pareira.''   It was identified among the verified anti-inflammatory components in an extract of ''Sinomenii caulis'' and has been proposed to have other potential physiological effects, such as sedative and anxiolytic, reduction of erythrocyte hemolysis, antifungal activity, improvement of LPS-induced acute lung injury, and protection against muscle atrophy. Furthermore, magnoflorine has been identified to be an inhibitor of NF-κB activation and to be an agonist An agonist is a chemical that activates a receptor to produce a biological response. Receptors are cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an antagonist blocks the action of the ago ... at the β2 -adren ...
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Sitosterol
β-sitosterol (beta-sitosterol) is one of several phytosterols (plant sterols) with chemical structures similar to that of cholesterol. It is a white, waxy powder with a characteristic odor, and is one of the components of the food additive E499. Phytosterols are hydrophobic and soluble in alcohols. Natural occurrences and food β-sitosterol is widely distributed in the plant kingdom. It is found in vegetable oil, nuts, avocados, and derived prepared foods such as salad dressings. Human research β-sitosterol is being studied for its potential to reduce benign prostatic hyperplasia (BPH) and blood cholesterol levels. Genetic disorder While plant sterols are usually beneficial, there is a rare autosomal recessive genetic disorder phytosterolemia which causes over-absorption of phytosterols. Precursor of anabolic steroid boldenone Being a steroid, β-sitosterol is a precursor of anabolic steroid boldenone. Boldenone undecylenate is commonly used in veterinary medicine to induce ...
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Hesperidin
Hesperidin is a flavanone glycoside found in citrus fruits. Its aglycone form is called hesperetin. Its name is derived from the word "hesperidium", for fruit produced by citrus trees. Hesperidin was first isolated in 1828 by French chemist M. Lebreton from the white inner layer of citrus peels (mesocarp, albedo). Hesperidin is believed to play a role in plant defense. Sources ''Rutaceae'' * 700–2,500 ppm in fruit of ''Citrus aurantium'' (bitter orange, petitgrain) * in orange juice (''Citrus sinensis'') * in ''Zanthoxylum gilletii'' * in lemon * in lime * in leaves of ''Agathosma serratifolia'' ''Lamiaceae'' Peppermint contains hesperidin. Content in foods Approximate hesperidin content per 100 ml * 481 mg peppermint, dried * 44 mg blood orange, pure juice * 26 mg orange, pure juice * 18 mg lemon, pure juice * 14 mg lime, pure juice * 1 mg grapefruit, pure juice Metabolism Hesperidin 6-''O''-α--rhamnosyl-β--glucosidase, an enzyme ...
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Lupeol
Lupeol is a pharmacologically active pentacyclic triterpenoid. It has several potential medicinal properties, like anticancer and anti-inflammatory activity. Natural occurrences Lupeol is found in a variety of plants, including mango, '' Acacia visco'' and '' Abronia villosa''. It is also found in dandelion coffee. Lupeol is present as a major component in ''Camellia japonica'' leaf. Total synthesis The first total synthesis of lupeol was reported by Gilbert Stork ''et al''. In 2009, Surendra and Corey reported a more efficient and enantioselective total synthesis of lupeol, starting from (''1E,5E'')-8- ''2S'')-3,3-dimethyloxiran-2-yl2,6-dimethylocta-1,5-dienyl acetate by use of a polycyclization. Biosynthesis Lupeol is produced by several organisms from squalene epoxide. Dammarane and baccharane skeletons are formed as intermediates. The reactions are catalyzed by the enzyme lupeol synthase. A recent study on the metabolomics of ''Camellia japonica'' leaf revealed t ...
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Nitidine
Nitidine is a benzophenanthridine alkaloid found in species of the genus ''Zanthoxylum '', notably in ''Zanthoxylum nitidum ''Zanthoxylum nitidum'', commonly known as shiny-leaf prickly-ash, tez-mui (in Assamese) or liang mian zhen (in China), is a species of flowering plant in the family Rutaceae. It is a woody climber with prickles on the branchlets, thick, cone- ...''. This compound has an anti-malarial activity.Bouquet, J., et al. (2012)Biological activities of nitidine, a potential anti-malarial lead compound.''Malaria Journal'' 11:67 References Isoquinoline alkaloids Benzodioxoles Quinoline alkaloids Alkaloids found in Rutaceae Antimalarial agents {{alkaloid-stub ...
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