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Yuan Chang
Yuan Chang (; born 17 November 1959) is a Taiwanese-American virologist and pathologist who co-discovered together with her husband, Patrick S. Moore, the Kaposi's sarcoma-associated herpesvirus (KSHV) and Merkel cell polyomavirus, two of the seven known human oncoviruses. Early life and education Chang was born in Taiwan and moved to the United States as a young child. She was raised in Salt Lake City, Utah and received an MD from the University of Utah College of Medicine. Chang trained in neuropathology at Stanford University under the noted clinical neuropathologist, Dikran Horoupian, publishing studies on eosinophilia-myalgia syndrome and progressive multifocal leukoencephalopathy. During this period she contributed to studies led by her friend, Julie Parsonnet, showing that Helicobacter pylori is a cause for gastric cancer. Career Chang moved to Columbia University to pursue her first academic appointment as a clinician-scientist. Although initially interested in using ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Zhang (surname)
Zhang () is the third most common surname in China and Taiwan (commonly spelled as "Chang" in Taiwan), and it is one of the most common surnames in the world. Zhang is the pinyin romanization of the very common Chinese surname written in simplified characters and in traditional characters. It is spoken in the first tone: ''Zhāng''. It is a surname that exists in many languages and cultures, corresponding to the surname 'Archer' in English for example. In the Wade-Giles system of romanization, it is romanized as "Chang", which is commonly used in Taiwan; "Cheung" is commonly used in Hong Kong as romanization. It is also the pinyin romanization of the less-common surnames (''Zhāng''), which is the 40th name on the ''Hundred Family Surnames'' poem. There is the even-less common (''Zhǎng''). was listed 24th in the famous Song-era ''Hundred Family Surnames'', contained in the verse 何呂施張 (He Lü Shi Zhang). Today, it is one of the most common surnames in the world a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Taiwanese-American
Taiwanese Americans () are Americans who carry full or partial ancestry from Taiwan. This includes American-born citizens who descend from migrants from Taiwan. As of the 2010 U.S. Census, 49% of Taiwanese Americans lived in the state of California. New York and Texas have the second and third largest Taiwanese American populations, respectively. Notable Taiwanese Americans include Joy Burke, Elaine Chao, Steve Chen, Michael Chang, Yuan Chang, Jensen Huang, Justin Lin, Jeremy Lin, Lisa Su, Katherine Tai, Constance Wu, Michelle Wu, Andrew Yang, and Jerry Yang. Immigration history Taiwanese immigration to the United States was limited in the years before World War II, due to Japanese rule as well as the Immigration Act of 1924, which completely barred immigration from Asia. Prior to the 1950s, emigration from Taiwan (ROC) (then called Formosa), was negligible, but a small number of students came to the United States until 1965. After the passage of the Immigration and Nat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Immunoevasin
Immunoevasins are proteins expressed by some viruses that enable the virus to evade immune recognition by interfering with MHC I complexes in the infected cell, therefore blocking the recognition of viral protein fragments by CD8+ cytotoxic T lymphocytes. Less frequently, MHC II antigen presentation and induced-self molecules may also be targeted. Some viral immunoevasins block peptide entry into the endoplasmic reticulum (ER) by targeting the TAP transporters. Immunoevasins are particularly abundant in viruses that are capable of establishing long-term infections of the host, such as herpesviruses. Mechanism Each step in the peptide loading and presentation on MHC I (or MHC II) is a potential target for viral immunoevasins. These can range from targeting MHC I for lysosomal or cytoplasmic degradation, blocking TCR recognition of MHC I, inhibition of peptide transport into the ER or retention of MHC I in the ER or pre- Golgi. For MHC II, the possible evasion routes include MHC ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Castleman's Disease
Castleman disease (CD) describes a group of rare lymphoproliferative disorders that involve enlarged lymph nodes, and a broad range of inflammatory symptoms and laboratory abnormalities. Whether Castleman disease should be considered an autoimmune disease, cancer, or infectious disease is currently unknown. Castleman disease includes at least three distinct subtypes: unicentric Castleman disease (UCD), human herpesvirus 8 associated multicentric Castleman disease (HHV-8-associated MCD), and idiopathic multicentric Castleman disease (iMCD). These are differentiated by the number and location of affected lymph nodes and the presence of human herpesvirus 8, a known causative agent in a portion of cases. Correctly classifying the Castleman disease subtype is important, as the three subtypes vary significantly in symptoms, clinical findings, disease mechanism, treatment approach, and prognosis. All forms involve overproduction of cytokines and other inflammatory proteins by the body ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Primary Effusion Lymphoma
Primary effusion lymphoma (PEL) is classified as a diffuse large B cell lymphoma. It is a rare malignancy of plasmablastic cells that occurs in individuals that are infected with the Kaposi's sarcoma-associated herpesvirus (i.e. KSHV/HHV8). Plasmablasts are immature plasma cells, i.e. lymphocytes of the B-cell type that have differentiated into plasmablasts but because of their malignant nature do not differentiate into mature plasma cells but rather proliferate excessively and thereby cause life-threatening disease. In PEL, the proliferating plasmablastoid cells commonly accumulate within body cavities to produce effusions (i.e. accumulations of fluid), primarily in the pleural, pericardial, or peritoneal cavities, without forming a contiguous tumor mass. In rare cases of these cavitary forms of PEL, the effusions develop in joints, the epidural space surrounding the brain and spinal cord, and underneath the capsule (i.e. tightly woven collagen fibers) which forms around breast ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
HHV-8
Kaposi's sarcoma-associated herpesvirus (KSHV) is the ninth known human herpesvirus; its formal name according to the International Committee on Taxonomy of Viruses (ICTV) is ''Human gammaherpesvirus 8'', or HHV-8 in short. Like other herpesviruses, its informal names are used interchangeably with its formal ICTV name. This virus causes Kaposi's sarcoma, a cancer commonly occurring in AIDS patients, as well as primary effusion lymphoma, HHV-8-associated multicentric Castleman's disease and KSHV inflammatory cytokine syndrome. It is one of seven currently known human cancer viruses, or oncoviruses. Even after so many years of discovery of KSHV/HHV8, there is no known cure for KSHV associated tumorigenesis. History In 1872, Moritz Kaposi described a blood vessel tumor (originally called "idiopathic multiple pigmented sarcoma of the skin") that has since been eponymously named Kaposi's sarcoma (KS). KS was at first thought to be an uncommon tumor of Jewish and Mediterranean popul ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kaposi's Sarcoma
Kaposi's sarcoma (KS) is a type of cancer that can form masses in the skin, in lymph nodes, in the mouth, or in other organs. The skin lesions are usually painless, purple and may be flat or raised. Lesions can occur singly, multiply in a limited area, or may be widespread. Depending on the sub-type of disease and level of immune suppression, KS may worsen either gradually or quickly. Except for Classical KS where there is generally no immune suppression, KS is caused by a combination of immune suppression (such as due to HIV/AIDS) and infection by Human herpesvirus 8 (HHV8 – also called KS-associated herpesvirus (KSHV)). Four sub-types are described: classic, endemic, immunosuppression therapy-related (also called iatrogenic), and epidemic (also called AIDS-related). Classic KS tends to affect older men in regions where KSHV is highly prevalent (Mediterranean, Eastern Europe, Middle East), is usually slow-growing, and most often affects only the legs. Endemic KS is most commo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Representational Difference Analysis
Representational difference analysis (RDA) is a technique used in biological research to find sequence differences in two genomic or cDNA samples. Genomes or cDNA sequences from two samples (i.e. cancer sample and a normal sample) are PCR amplified and differences analyzed using subtractive DNA hybridization. This technology has been further enhanced through the development of representation oligonucleotide microarray analysis (ROMA), which uses array An array is a systematic arrangement of similar objects, usually in rows and columns. Things called an array include: {{TOC right Music * In twelve-tone and serial composition, the presentation of simultaneous twelve-tone sets such that the ... technology to perform such analyses. This method may also be adapted to detect DNA methylation differences, as seen in methylation-sensitive representational difference analysis (MS-RDA). Theory This method relies on PCR to differentially amplify non-homologous DNA regions between ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Julie Parsonnet
Julie Parsonnet is an infectious disease expert. She is a Fellow of the National Academy of Medicine and American Society for Clinical Investigation. Early life and education Parsonnet grew up in Millburn, New Jersey alongside father Victor Parsonnet and attended Millburn High School. Following high school, she graduated magna cum laude from Harvard University with a bachelor's degree in history and science. As a sophomore at Harvard, she spent a summer as an intern with Senator Clifford P. Case. Following Harvard, Parsonnet enrolled at Cornell University for her medical degree. Upon graduating in 1983, she had received the John Metcalf Polk Prize for General Efficiency as a student with the highest academic standing over four years, the Clarence C. Coryell Prize in Medicine for having the highest average in medicine through the junior year, the Alfred Moritz Michaelis Prize Endowment for Efficiency in General Medicine, and the American Medical Women's Association Scholarship Cit ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Progressive Multifocal Leukoencephalopathy
Progressive multifocal leukoencephalopathy (PML) is a rare and often fatal viral disease characterized by progressive damage (''-pathy'') or inflammation of the white matter (''leuko-'') of the brain (''-encephalo-'') at multiple locations (''multifocal''). It is caused by the JC virus, which is normally present and kept under control by the immune system. The JC virus is harmless except in cases of weakened immune systems. In general, PML has a mortality rate of 30–50% in the first few months, and those who survive can be left with varying degrees of neurological disabilities. PML occurs almost exclusively in patients with severe immune deficiency, most commonly among patients with acquired immune deficiency syndrome (AIDS), but people on chronic immunosuppressive medications including chemotherapy are also at increased risk of PML, such as patients with transplants, Hodgkin's lymphoma, multiple sclerosis, psoriasis, rheumatoid arthritis, and other autoimmune diseases. Sign ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stanford University
Stanford University, officially Leland Stanford Junior University, is a private research university in Stanford, California. The campus occupies , among the largest in the United States, and enrolls over 17,000 students. Stanford is considered among the most prestigious universities in the world. Stanford was founded in 1885 by Leland and Jane Stanford in memory of their only child, Leland Stanford Jr., who had died of typhoid fever at age 15 the previous year. Leland Stanford was a U.S. senator and former governor of California who made his fortune as a railroad tycoon. The school admitted its first students on October 1, 1891, as a coeducational and non-denominational institution. Stanford University struggled financially after the death of Leland Stanford in 1893 and again after much of the campus was damaged by the 1906 San Francisco earthquake. Following World War II, provost of Stanford Frederick Terman inspired and supported faculty and graduates' entrepreneu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
