|
Yousef Al-Abed
Yousef Al-Abed is the head of the Center for Molecular Innovation at the Northwell's Feinstein Institute for Medical Research, in Manhasset, New York. An organic chemist by training, Dr. Al-Abed holds dual-appointment as a Professor of Molecular Medicine and Medicine at Hofstra Northwell School of Medicine. Al-Abed received his Bachelor of Science degree in Chemistry and Chemical Technology from the College of Science and Technology in Jerusalem in 1985, followed by his Master of Science degree in organic chemistry from the University of Jordan in 1989 and his PhD in organic chemistry from the University of Tübingen, Germany in 1994. He then served as a postdoctoral investigator at the Picower Institute for Medical Research, now known as the Feinstein Institute. Al-Abed's research has focused on a protein called macrophage migration inhibitory factor as a drug target for autoimmune disease and inflammation Inflammation (from la, inflammatio) is part of the complex biol ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hebron
Hebron ( ar, الخليل or ; he, חֶבְרוֹן ) is a Palestinian. city in the southern West Bank, south of Jerusalem. Nestled in the Judaean Mountains, it lies above sea level. The second-largest city in the West Bank (after East Jerusalem), and the third-largest in the Palestinian territories (after East Jerusalem and Gaza), it has a population of over 215,000 Palestinians (2016), and seven hundred Jewish settlers concentrated on the outskirts of its Old City. It includes the Cave of the Patriarchs, which Jewish, Christian, and Islamic traditions all designate as the burial site of three key patriarchal/ matriarchal couples. The city is often considered one of the four holy cities in Judaism. as well as in Islam. Hebron is considered one of the oldest cities in the Levant. According to the Bible, Abraham settled in Hebron and bought the Cave of the Patriarchs as a burial place for his wife Sarah. Biblical tradition holds that the patriarchs Abraham, Isaac, and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
West Bank
The West Bank ( ar, الضفة الغربية, translit=aḍ-Ḍiffah al-Ġarbiyyah; he, הגדה המערבית, translit=HaGadah HaMaʽaravit, also referred to by some Israelis as ) is a landlocked territory near the coast of the Mediterranean Sea, Mediterranean in Western Asia that forms the main bulk of the Palestinian territories. It is bordered by Jordan and the Dead Sea to the east and by Israel (see Green Line (Israel), Green Line) to the south, west, and north. Under Israeli occupation of the West Bank, an Israeli military occupation since 1967, its area is split into 165 Palestinian enclaves, Palestinian "islands" that are under total or partial civil administration by the Palestinian National Authority (PNA), and 230 Israeli settlements into which Israeli law in the West Bank settlements, Israeli law is "pipelined". The West Bank includes East Jerusalem. It initially emerged as a Jordanian-occupied territory after the 1948 Arab–Israeli War, before being Jordani ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Organic Chemistry
Organic chemistry is a subdiscipline within chemistry involving the scientific study of the structure, properties, and reactions of organic compounds and organic materials, i.e., matter in its various forms that contain carbon atoms.Clayden, J.; Greeves, N. and Warren, S. (2012) ''Organic Chemistry''. Oxford University Press. pp. 1–15. . Study of structure determines their structural formula. Study of properties includes physical and chemical properties, and evaluation of chemical reactivity to understand their behavior. The study of organic reactions includes the chemical synthesis of natural products, drugs, and polymers, and study of individual organic molecules in the laboratory and via theoretical ( in silico) study. The range of chemicals studied in organic chemistry includes hydrocarbons (compounds containing only carbon and hydrogen) as well as compounds based on carbon, but also containing other elements, especially oxygen, nitrogen, sulfur, phosphorus (included in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Medicinal Chemistry
Medicinal or pharmaceutical chemistry is a scientific discipline at the intersection of chemistry and pharmacy involved with designing and developing pharmaceutical drugs. Medicinal chemistry involves the identification, synthesis and development of new chemical entities suitable for therapeutic use. It also includes the study of existing drugs, their biological properties, and their quantitative structure-activity relationships (QSAR). Medicinal chemistry is a highly interdisciplinary science combining organic chemistry with biochemistry, computational chemistry, pharmacology, molecular biology, statistics, and physical chemistry. Compounds used as medicines are most often organic compounds, which are often divided into the broad classes of small organic molecules (e.g., atorvastatin, fluticasone, clopidogrel) and "biologics" (infliximab, erythropoietin, insulin glargine), the latter of which are most often medicinal preparations of proteins (natural and recombinant ant ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Jordan
The University of Jordan ( ar, الجامعة الأردنية), often abbreviated UJ, is a public university located in Amman, Jordan. Founded in 1962 by royal decree, it is the largest and oldest institution of higher education in Jordan. It is located in the capital Amman in the Jubaiha area of the University District. It is composed of 20 faculties and over 95 departments. The University District where the University of Jordan is located in is considered one of the most developed parts of Amman, with a rich history of education and culture and a high population density. The University of Jordan is often nicknamed The Mother University ( ar, الجامعة الأُم), the nickname stems from the fact that it's the first university in Jordan and it has graduated many public and political figures who took on important roles in the government and media and helped establish other universities in Jordan and neighboring countries. History Before the founding of the Unive ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Tübingen
The University of Tübingen, officially the Eberhard Karl University of Tübingen (german: Eberhard Karls Universität Tübingen; la, Universitas Eberhardina Carolina), is a public research university located in the city of Tübingen, Baden-Württemberg, Germany. The University of Tübingen is one of eleven German Excellence Universities. The University of Tübingen is especially known as a centre for the study of plant biology, medicine, law, archeology, ancient cultures, philosophy, theology, and religious studies as well as more recently as center of excellence for artificial intelligence. The university's noted alumni include presidents, EU Commissioners, and judges of the Federal Constitutional Court. The university is associated with eleven Nobel laureates, especially in the fields of medicine and chemistry. History The University of Tübingen was founded in 1477 by Count Eberhard V (Eberhard im Bart, 1445–1496), later the first Duke of Württemberg, a civic and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Feinstein Institute For Medical Research
The Feinstein Institutes for Medical Research in Manhasset, Nassau County, New York, United States, on Long Island, constitute the research arm of Northwell Health. Feinstein is home to 50 research labs, 2,500 clinical research studies, and 5,000 professional and support staff. Feinstein scientists conduct research in molecular medicine, genetics, cancer, brain research, mental health, autoimmunity and bioelectronic medicine, among others. Feinstein is the laboratory and faculty home of thElmezzi Graduate School of Molecular Medicine Students without an MD degree may earn a PhD in molecular medicine via the Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, as part of the medical school's MD/PhD or PhD programs. The Feinstein Institutes acquired assets from the closing of the Picower Institute for Medical Research, founded in 1991 by Anthony Cerami and funded by Jeffry Picower. In 2001 the institute's funding was withdrawn and it closed; in 2002 it was acquired ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Northwell
Northwell Health is a nonprofit integrated healthcare network that is New York State's largest healthcare provider and private employer, with more than 81,000 employees. The flagship hospitals of Northwell are North Shore University Hospital and Long Island Jewish Medical Center (LIJ Medical Center). History Prior to 2015, the network was called North Shore-Long Island Jewish Health System (North Shore-LIJ). In 2019, Northwell had 23 hospitals and more than 700 outpatient facilities, as well as the Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, the Feinstein Institutes for Medical Research, urgent care centers, kidney dialysis centers, acute inpatient rehabilitation, sub-acute rehabilitation and skilled-nursing facilities, a home care network, a hospice network, and other services. More recently, the company signed a deal with software technology company Playback Health, to launch platforms for patient medical information to retain their healt ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Manhasset, New York
Manhasset is a Hamlet (New York), hamlet and census-designated place (CDP) in Nassau County, New York, Nassau County, on the North Shore (Long Island), North Shore of Long Island, in New York (state), New York. It is considered the anchor community of the Greater Manhasset area. The population was 8,176 at the 2020 United States census. As with other unincorporated communities in New York, its local affairs are administered by the town in which it is located, the North Hempstead, New York, Town of North Hempstead, whose North Hempstead Town Hall, town hall is in Manhasset, making the hamlet the Seat of government, town seat. Etymology The name Manhasset was adopted in 1840. It is most likely the anglicized rendition of the name of a local Native Americans in the United States, Native American tribe whose name translates to "the island neighborhood". History The Matinecock (tribe), Matinecock had a village on Manhasset Bay. These Native Americans called the area Sint Sink, meani ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hofstra Northwell School Of Medicine
The Donald and Barbara Zucker School of Medicine at Hofstra/Northwell is the graduate medical school of Hofstra University in the town of Hempstead on Long Island, in the U.S. state of New York. The academic institution was established in 2008 by Hofstra University and the North Shore-LIJ Hospital system which was rebranded as Northwell Health in 2015. The Zucker School of Medicine enrolls 99 students each year and offers an MD (doctor of medicine) and PhD (doctor of philosophy in the molecular basis of medicine). It also offers a joint MD—PhD degree; joint MD— MPH (Master of Public Health); joint MD—MBA (Master of Business Administration); and joint MD—OMS (oral and maxillofacial surgery). It also offers a dual-degree "4+4" program comprising an undergraduate degree (BA or BS) followed by automatic matriculation to the School of Medicine. History In October 2007, Hofstra University and Northwell Health (then known as North Shore-LIJ) announced plans to establish a new ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Macrophage Migration Inhibitory Factor
Macrophage migration inhibitory factor (MIF), also known as glycosylation-inhibiting factor (GIF), L-dopachrome isomerase, or phenylpyruvate tautomerase is a protein that in humans is encoded by the ''MIF'' gene. MIF is an important regulator of innate immunity. The MIF protein superfamily also includes a second member with functionally related properties, the D-dopachrome tautomerase (D-DT). CD74 is a surface receptor for MIF. Bacterial antigens stimulate white blood cells to release MIF into the blood stream. The circulating MIF binds to CD74 on other immune cells to trigger an acute immune response. Hence, MIF is classified as an inflammatory cytokine. Furthermore, glucocorticoids also stimulate white blood cells to release MIF and hence MIF partially counteracts the inhibitory effects that glucocorticoids have on the immune system. Finally trauma activates the anterior pituitary gland to release MIF. Structure Macrophage migration inhibitory factor assembles into a trimer c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biological Target
A biological target is anything within a living organism to which some other entity (like an endogenous ligand or a drug) is directed and/or binds, resulting in a change in its behavior or function. Examples of common classes of biological targets are proteins and nucleic acids. The definition is context-dependent, and can refer to the biological target of a pharmacologically active drug compound, the receptor target of a hormone (like insulin), or some other target of an external stimulus. Biological targets are most commonly proteins such as enzymes, ion channels, and receptors. Mechanism The external stimulus (''i.e.'', the drug or ligand) physically binds to ("hits") the biological target. The interaction between the substance and the target may be: * noncovalent – A relatively weak interaction between the stimulus and the target where no chemical bond is formed between the two interacting partners and hence the interaction is completely reversible. * reversible covalent ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
