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Xue-Min Cheng
Xue-Min Cheng is a medicinal chemist, author and pharmaceutical executive best known as the co-author of ''The Logic of Chemical Synthesis'', which formalized retrosynthesis. The concept for this Elias J. Corey won the 1990 Nobel Prize in Chemistry. Education and Postdoctoral research Cheng earned her BS in chemistry from Peking University, and a doctoral degree in synthetic chemistry from Alan Kozikowski at the University of Pittsburgh. Her work studied applications of nitrile oxides, for example cycloadditions to form C-glycosides, or utilization of nitrile oxides as precursors to functionalized heterocycles. While a postdoctoral scholar at Harvard, Cheng co-authored ''The Logic of Chemical Synthesis'' with Corey, the first three chapters of which explore computational and logic-based approaches to disassemble organic molecule "targets" (TGTs) through various transforms, leading to "retrons" and "synthons", e.g. simpler molecules that could be used to access the TGT. Notewort ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Retrosynthetic Analysis
Retrosynthetic analysis is a technique for solving problems in the planning of organic syntheses. This is achieved by transforming a target molecule into simpler precursor structures regardless of any potential reactivity/interaction with reagents. Each precursor material is examined using the same method. This procedure is repeated until simple or commercially available structures are reached. These simpler/commercially available compounds can be used to form a synthesis of the target molecule. E.J. Corey formalized this concept in his book ''The Logic of Chemical Synthesis''. The power of retrosynthetic analysis becomes evident in the design of a synthesis. The goal of retrosynthetic analysis is a structural simplification. Often, a synthesis will have more than one possible synthetic route. Retrosynthesis is well suited for discovering different synthetic routes and comparing them in a logical and straightforward fashion. A database may be consulted at each stage of the analysis, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pfizer
Pfizer Inc. ( ) is an American multinational pharmaceutical and biotechnology corporation headquartered on 42nd Street in Manhattan, New York City. The company was established in 1849 in New York by two German entrepreneurs, Charles Pfizer (1824–1906) and his cousin Charles F. Erhart (1821–1891). Pfizer develops and produces medicines and vaccines for immunology, oncology, cardiology, endocrinology, and neurology. The company has several blockbuster drugs or products that each generate more than billion in annual revenues. In 2020, 52% of the company's revenues came from the United States, 6% came from each of China and Japan, and 36% came from other countries. Pfizer was a component of the Dow Jones Industrial Average stock market index from 2004 to August 2020. The company ranks 64th on the Fortune 500 and 49th on the Forbes Global 2000. History 1849–1950: Early history Pfizer was founded in 1849 by Charles Pfizer and Charles F. Erhart, two cousins who had i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Harvard University People
The list of Harvard University people includes notable graduates, professors, and administrators affiliated with Harvard University. For a list of notable non-graduates of Harvard, see notable non-graduate alumni of Harvard. For a list of Harvard's presidents, see President of Harvard University. Eight Presidents of the United States have graduated from Harvard University: John Adams, John Quincy Adams, Rutherford B. Hayes, John F. Kennedy, Franklin Delano Roosevelt, Theodore Roosevelt, George W. Bush, and Barack Obama. Bush graduated from Harvard Business School, Hayes and Obama from Harvard Law School, and the others from Harvard College. Over 150 Nobel Prize winners have been associated with the university as alumni, researchers or faculty. Nobel laureates Pulitzer Prize winners ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Pittsburgh Alumni
A university () is an institution of higher (or tertiary) education and research which awards academic degrees in several academic disciplines. Universities typically offer both undergraduate and postgraduate programs. In the United States, the designation is reserved for colleges that have a graduate school. The word ''university'' is derived from the Latin ''universitas magistrorum et scholarium'', which roughly means "community of teachers and scholars". The first universities were created in Europe by Catholic Church monks. The University of Bologna (''Università di Bologna''), founded in 1088, is the first university in the sense of: *Being a high degree-awarding institute. *Having independence from the ecclesiastic schools, although conducted by both clergy and non-clergy. *Using the word ''universitas'' (which was coined at its foundation). *Issuing secular and non-secular degrees: grammar, rhetoric, logic, theology, canon law, notarial law.Hunt Janin: "The university in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Michigan Faculty
A university () is an institution of higher (or tertiary) education and research which awards academic degrees in several academic disciplines. Universities typically offer both undergraduate and postgraduate programs. In the United States, the designation is reserved for colleges that have a graduate school. The word ''university'' is derived from the Latin ''universitas magistrorum et scholarium'', which roughly means "community of teachers and scholars". The first universities were created in Europe by Catholic Church monks. The University of Bologna (''Università di Bologna''), founded in 1088, is the first university in the sense of: *Being a high degree-awarding institute. *Having independence from the ecclesiastic schools, although conducted by both clergy and non-clergy. *Using the word ''universitas'' (which was coined at its foundation). *Issuing secular and non-secular degrees: grammar, rhetoric, logic, theology, canon law, notarial law.Hunt Janin: "The university ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chinese Women Scientists
Chinese can refer to: * Something related to China * Chinese people, people of Chinese nationality, citizenship, and/or ethnicity **''Zhonghua minzu'', the supra-ethnic concept of the Chinese nation ** List of ethnic groups in China, people of various ethnicities in contemporary China ** Han Chinese, the largest ethnic group in the world and the majority ethnic group in Mainland China, Hong Kong, Macau, Taiwan, and Singapore ** Ethnic minorities in China, people of non-Han Chinese ethnicities in modern China ** Ethnic groups in Chinese history, people of various ethnicities in historical China ** Nationals of the People's Republic of China ** Nationals of the Republic of China ** Overseas Chinese, Chinese people residing outside the territories of Mainland China, Hong Kong, Macau, and Taiwan * Sinitic languages, the major branch of the Sino-Tibetan language family ** Chinese language, a group of related languages spoken predominantly in China, sharing a written script (Chi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DARPA
The Defense Advanced Research Projects Agency (DARPA) is a research and development agency of the United States Department of Defense responsible for the development of emerging technologies for use by the military. Originally known as the Advanced Research Projects Agency (ARPA), the agency was created on February 7, 1958, by President Dwight D. Eisenhower in response to the Soviet Union, Soviet launching of Sputnik 1 in 1957. By collaborating with academia, industry, and government partners, DARPA formulates and executes research and development projects to expand the frontiers of technology and science, often beyond immediate U.S. military requirements.Dwight D. Eisenhower and Science & Technology, (2008). Dwight D. Eisenhower Memorial CommissionSource ''The Economist'' has called DARPA the agency "that shaped the modern world," and pointed out that "Moderna COVID-19 vaccine, Moderna's COVID-19 vaccine sits alongside weather satellites, Global Positioning System, GPS, Unmann ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Helen T
Helen may refer to: People * Helen of Troy, in Greek mythology, the most beautiful woman in the world * Helen (actress) (born 1938), Indian actress * Helen (given name), a given name (including a list of people with the name) Places * Helen, Georgia, United States, a small city * Helen, Maryland, United States, an unincorporated place * Helen, Washington, an unincorporated community in Washington state, US * Helen, West Virginia, a census-designated place in Raleigh County * Helen Falls, a waterfall in Ontario, Canada * Lake Helen (other), several places called Helen Lake or Lake Helen * Helen, an ancient name of Makronisos island, Greece * The Hellenic Republic, Greece Arts, entertainment, and media * ''Helen'' (album), a 1981 Grammy-nominated album by Helen Humes * ''Helen'' (2008 film), a British drama starring Annie Townsend * ''Helen'' (2009 film), an American drama film starring Ashley Judd * ''Helen'' (2017 film), an Iranian drama film * ''Helen'' (2019 fil ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Atorvastatin
Atorvastatin is a statin medication used to prevent cardiovascular disease in those at high risk and to treat abnormal lipid levels. For the prevention of cardiovascular disease, statins are a first-line treatment. It is taken by mouth. Common side effects include joint pain, diarrhea, heartburn, nausea, and muscle pains. Serious side effects may include rhabdomyolysis, liver problems, and diabetes. Use during pregnancy may harm the fetus. Like all statins, atorvastatin works by inhibiting HMG-CoA reductase, an enzyme found in the liver that plays a role in producing cholesterol. Atorvastatin was patented in 1986, and approved for medical use in the United States in 1996. It is on the World Health Organization's List of Essential Medicines. It is available as a generic medication. In 2020, it was the most commonly prescribed medication in the United States, with more than 114million prescriptions. Medical uses The primary uses of atorvastatin is for the treatment of dyslipide ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
HMG-CoA
β-Hydroxy β-methylglutaryl-CoA (HMG-CoA), also known as 3-hydroxy-3-methylglutaryl coenzyme A, is an intermediate in the mevalonate and ketogenesis pathways. It is formed from acetyl CoA and acetoacetyl CoA by HMG-CoA synthase. The research of Minor J. Coon and Bimal Kumar Bachhawat in the 1950s at University of Illinois led to its discovery. HMG-CoA is a metabolic intermediate in the metabolism of the branched-chain amino acids, which include leucine, isoleucine, and valine. Its immediate precursors are β-methylglutaconyl-CoA (MG-CoA) and β-hydroxy β-methylbutyryl-CoA (HMB-CoA). HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonic acid, a necessary step in the biosynthesis of cholesterol. Biosynthesis Mevalonate pathway Mevalonate synthesis begins with the beta-ketothiolase-catalyzed Claisen condensation of two molecules of acetyl-CoA to produce acetoacetyl CoA. The following reaction involves the joining of acetyl-CoA and acetoacetyl-CoA to form HMG ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Renin
Renin (etymology and pronunciation), also known as an angiotensinogenase, is an aspartic protease protein and enzyme secreted by the kidneys that participates in the body's renin–angiotensin–aldosterone system (RAAS)—also known as the renin–angiotensin–aldosterone axis—that increases the volume of extracellular fluid (blood plasma, lymph and interstitial fluid) and causes arterial vasoconstriction. Thus, it increases the body's mean arterial blood pressure. Renin is not commonly referred to as a hormone, albeit it having a receptor, the (pro)renin receptor, also known as the renin receptor and prorenin receptor (see also below), as well as enzymatic activity with which it hydrolyzes angiotensinogen to angiotensin I. Biochemistry and physiology Structure The primary structure of renin precursor consists of 406 amino acids with a pre- and a pro-segment carrying 20 and 46 amino acids, respectively. Mature renin contains 340 amino acids and has a mass of 37 kDa. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Warner–Lambert
Warner–Lambert was an American pharmaceutical company. History Formerly two separate entities, the first company was started in 1856, when William R. Warner founded a drug store in Philadelphia. Warner went on to invent a tablet coating process gaining him a place in the Smithsonian Institution. The second half of the name came from Jordan Wheat Lambert, founder of the Lambert Pharmacal Company of St. Louis, famous for Listerine. The two companies merged in 1955, to form Warner–Lambert. Over the years, the company expanded through many mergers and acquisitions to become an international competitor in several businesses. In 1956, Warner-Lambert acquired Nepera Chemical (the makers of Anahist) from the Lasdon family, many of whom then became officers and directors of the merged business. In 1976, Warner–Lambert took over Parke-Davis, which was founded in Detroit in 1866, by Hervey Parke and George Davis. This was followed by acquisitions of Wilkinson Sword in March 1993, and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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