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Xenobot
Xenobots, named after the African clawed frog (''Xenopus laevis''), are synthetic lifeforms that are designed by computers to perform some desired function and built by combining together different biological tissues. Whether xenobots are robots, organisms, or something else entirely remains a subject of debate among scientists. Existing xenobots The first xenobots were built by Douglas Blackiston according to blueprints generated by an AI program, which was developed by Sam Kriegman. Xenobots built to date have been less than wide and composed of just two things: skin cells and heart muscle cells, both of which are derived from stem cells harvested from early ( blastula stage) frog embryos. The skin cells provide rigid support and the heart cells act as small motors, contracting and expanding in volume to propel the xenobot forward. The shape of a xenobot's body, and its distribution of skin and heart cells, are automatically designed in simulation to perform a specific t ...
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Michael Levin (biologist)
Michael Levin is an American developmental biology, developmental and synthetic biology, synthetic biologist at Tufts University, where he is the Vannevar Bush Distinguished Professor. Levin is a director of the Allen Discovery Center at Tufts University and Tufts Center for Regenerative and Developmental Biology. He is also co-director of the Institute for Computationally Designed Organisms with Joshua Bongard. Early life Michael Levin was born in Moscow, USSR, in 1969, in a Jewish family. His parents faced antisemitism in the Soviet Union, and in 1978 took advantage of a visa program for Soviet Jews and moved the family to Lynn, Massachusetts. Levin's father was a computer programmer and worked for the Soviet weather service; his mother was a concert pianist. Levin's family immigration was sponsored by Temple Sinai in Marblehead, Massachusetts. His family is still members of Temple Sinai. Levin stated that "... I've always lived within about a mile radius of where we landed ...
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Josh Bongard
Josh Bongard is a professor at the University of Vermont and a 2010 PECASE awardee. He attended Northern Secondary School in Toronto, and received his bachelor's degree in Computer Science from McMaster University ('97), Canada, his master's degree from the University of Sussex, United Kingdom, UK, and his PhD from the University of Zurich (1999-2003), Switzerland. He served as a postdoctoral associate under Hod Lipson in the Computational Synthesis Laboratory at Cornell University in the United States from 2003 to 2006. He is the co-author of the popular science book entitled "How the Body Shapes the Way We Think: A New View of Intelligence", MIT Press, November 2006. (With Rolf Pfeifer) . He is also the co-author of "Designing Intelligence: Why Brains Aren't Enough" (with Rolf Pfeifer and Don Berry) . In 2007, he was named to the Massachusetts Institute of Technology, MIT Technology Review TR35 as one of the top 35 innovators in the world under the age of 35. Selected publica ...
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Microbots
Microbotics (or microrobotics) is the field of miniature robotics, in particular mobile robots with characteristic dimensions less than 1 mm. The term can also be used for robots capable of handling micrometer size components. History Microbots were born thanks to the appearance of the microcontroller in the last decade of the 20th century, and the appearance of microelectromechanical systems (MEMS) on silicon, although many microbots do not use silicon for mechanical components other than sensors. The earliest research and conceptual design of such small robots was conducted in the early 1970s in (then) classified research for U.S. intelligence agencies. Applications envisioned at that time included prisoner of war rescue assistance and electronic intercept missions. The underlying miniaturization support technologies were not fully developed at that time, so that progress in prototype development was not immediately forthcoming from this early set of calculations and concep ...
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Synthetic Biology
Synthetic biology (SynBio) is a multidisciplinary area of research that seeks to create new biological parts, devices, and systems, or to redesign systems that are already found in nature. It is a branch of science that encompasses a broad range of methodologies from various disciplines, such as biotechnology, biomaterials, material science/engineering, genetic engineering, molecular biology, molecular engineering, systems biology, membrane science, biophysics, chemical and biological engineering, electrical and computer engineering, control engineering and evolutionary biology. Due to more powerful genetic engineering capabilities and decreased DNA synthesis and sequencing costs, the field of synthetic biology is rapidly growing. In 2016, more than 350 companies across 40 countries were actively engaged in synthetic biology applications; all these companies had an estimated net worth of $3.9 billion in the global market. Definition Synthetic biology currently has no gen ...
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Cilium
The cilium, plural cilia (), is a membrane-bound organelle found on most types of eukaryotic cell, and certain microorganisms known as ciliates. Cilia are absent in bacteria and archaea. The cilium has the shape of a slender threadlike projection that extends from the surface of the much larger cell body. Eukaryotic flagella found on sperm cells and many protozoans have a similar structure to motile cilia that enables swimming through liquids; they are longer than cilia and have a different undulating motion. There are two major classes of cilia: ''motile'' and ''non-motile'' cilia, each with a subtype, giving four types in all. A cell will typically have one primary cilium or many motile cilia. The structure of the cilium core called the axoneme determines the cilium class. Most motile cilia have a central pair of single microtubules surrounded by nine pairs of double microtubules called a 9+2 axoneme. Most non-motile cilia have a 9+0 axoneme that lacks the central pair o ...
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Fluorescence Microscope
A fluorescence microscope is an optical microscope that uses fluorescence instead of, or in addition to, scattering, reflection, and attenuation or absorption, to study the properties of organic or inorganic substances. "Fluorescence microscope" refers to any microscope that uses fluorescence to generate an image, whether it is a simple set up like an epifluorescence microscope or a more complicated design such as a confocal microscope, which uses optical sectioning to get better resolution of the fluorescence image. Principle The specimen is illuminated with light of a specific wavelength (or wavelengths) which is absorbed by the fluorophores, causing them to emit light of longer wavelengths (i.e., of a different color than the absorbed light). The illumination light is separated from the much weaker emitted fluorescence through the use of a spectral emission filter. Typical components of a fluorescence microscope are a light source (xenon arc lamp or mercury-vapor lamp are ...
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Morphogenesis
Morphogenesis (from the Greek ''morphê'' shape and ''genesis'' creation, literally "the generation of form") is the biological process that causes a cell, tissue or organism to develop its shape. It is one of three fundamental aspects of developmental biology along with the control of tissue growth and patterning of cellular differentiation. The process controls the organized spatial distribution of cells during the embryonic development of an organism. Morphogenesis can take place also in a mature organism, such as in the normal maintenance of tissue by stem cells or in regeneration of tissues after damage. Cancer is an example of highly abnormal and pathological tissue morphogenesis. Morphogenesis also describes the development of unicellular life forms that do not have an embryonic stage in their life cycle. Morphogenesis is essential for the evolution of new forms. Morphogenesis is a mechanical process involving forces that generate mechanical stress, strain, and moveme ...
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Biocompatibility
Biocompatibility is related to the behavior of biomaterials in various contexts. The term refers to the ability of a material to perform with an appropriate host response in a specific situation. The ambiguity of the term reflects the ongoing development of insights into how biomaterials interact with the human body and eventually how those interactions determine the clinical success of a medical device (such as pacemaker, hip replacement or stent). Modern medical devices and prostheses are often made of more than one material so it might not always be sufficient to talk about the biocompatibility of a specific material. Since the immune response and repair functions in the body are so complicated it is not adequate to describe the biocompatibility of a single material in relation to a single cell type or tissue. Sometimes one hears of biocompatibility testing that is a large battery of in vitro test that is used in accordance with ISO 10993 (or other similar standards) to det ...
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A Xenobot In Simulation And Reality
A, or a, is the first letter and the first vowel of the Latin alphabet, used in the modern English alphabet, the alphabets of other western European languages and others worldwide. Its name in English is ''a'' (pronounced ), plural ''aes''. It is similar in shape to the Ancient Greek letter alpha, from which it derives. The uppercase version consists of the two slanting sides of a triangle, crossed in the middle by a horizontal bar. The lowercase version can be written in two forms: the double-storey a and single-storey ɑ. The latter is commonly used in handwriting and fonts based on it, especially fonts intended to be read by children, and is also found in italic type. In English grammar, " a", and its variant " an", are indefinite articles. History The earliest certain ancestor of "A" is aleph (also written 'aleph), the first letter of the Phoenician alphabet, which consisted entirely of consonants (for that reason, it is also called an abjad to distinguish it fro ...
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Microplastics
Microplastics are fragments of any type of plastic less than in length, according to the U.S. National Oceanic and Atmospheric Administration (NOAA) and the European Chemicals Agency. They cause pollution by entering natural ecosystems from a variety of sources, including cosmetics, clothing, food packaging, and industrial processes. The term ''macroplastics'' is used to differentiate microplastics from larger plastic waste, such as plastic bottles. Two classifications of microplastics are currently recognized. Primary microplastics include any plastic fragments or particles that are already 5.0 mm in size or less before entering the environment. These include microfibers from clothing, microbeads, and plastic pellets (also known as nurdles). Secondary microplastics arise from the degradation (breakdown) of larger plastic products through natural weathering processes after entering the environment. Such sources of secondary microplastics include water and soda bottles, fis ...
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Blastula
Blastulation is the stage in early animal embryonic development that produces the blastula. In mammalian development the blastula develops into the blastocyst with a differentiated inner cell mass and an outer trophectoderm. The blastula (from Greek '' βλαστός'' ( meaning ''sprout'')) is a hollow sphere of cells known as blastomeres surrounding an inner fluid-filled cavity called the blastocoel. Embryonic development begins with a sperm fertilizing an egg cell to become a zygote, which undergoes many cleavages to develop into a ball of cells called a morula. Only when the blastocoel is formed does the early embryo become a blastula. The blastula precedes the formation of the gastrula in which the germ layers of the embryo form. A common feature of a vertebrate blastula is that it consists of a layer of blastomeres, known as the blastoderm, which surrounds the blastocoel. In mammals, the blastocyst contains an embryoblast (or inner cell mass) that will eventually give ri ...
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Artery
An artery (plural arteries) () is a blood vessel in humans and most animals that takes blood away from the heart to one or more parts of the body (tissues, lungs, brain etc.). Most arteries carry oxygenated blood; the two exceptions are the pulmonary and the umbilical arteries, which carry deoxygenated blood to the organs that oxygenate it (lungs and placenta, respectively). The effective arterial blood volume is that extracellular fluid which fills the arterial system. The arteries are part of the circulatory system, that is responsible for the delivery of oxygen and nutrients to all cells, as well as the removal of carbon dioxide and waste products, the maintenance of optimum blood pH, and the circulation of proteins and cells of the immune system. Arteries contrast with veins, which carry blood back towards the heart. Structure The anatomy of arteries can be separated into gross anatomy, at the macroscopic level, and microanatomy, which must be studied with a microscop ...
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