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William Bayliss
Sir William Maddock Bayliss (2 May 1860 – 27 August 1924) was an English physiologist. Life He was born in Wednesbury, Staffordshire but shortly thereafter his father, a successful merchant of ornamental ironwork, moved his family to a house he had built on West Heath Road in Hampstead in north London, which he named St Cuthberts. It stood in four acres of gardens. William was his sole heir. He began to study medicine at University College London in 1880, but dropped out when he failed anatomy. Attracted to physiology, he studied under John Burdon Sanderson at Wadham College, Oxford, where he won a first class degree, investigating electrical changes occurring during salivary secretion. He returned to University College London in 1888 as an assistant to Edward Sharpey-Schafer. In 1890 he began to collaborate with Ernest Starling, who was at Guy's Hospital, on the electrical activity of the heart. They complemented each other in many ways: for instance, Bayliss dealt with ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Wednesbury
Wednesbury () is a market town in Sandwell in the county of West Midlands, England. It is located near the source of the River Tame. Historically part of Staffordshire in the Hundred of Offlow, at the 2011 Census the town had a population of 37,817. History Medieval and earlier The substantial remains of a large ditch excavated in St Mary's Road in 2008, following the contours of the hill and predating the Early Medieval period, has been interpreted as part of a hilltop enclosure and possibly the Iron Age hillfort long suspected on the site. The first authenticated spelling of the name was Wodensbyri, written in an endorsement on the back of the copy of the will of Wulfric Spot, dated 1004. Wednesbury ("Woden's borough") is one of the few places in England to be named after a pre-Christian deity. During the Anglo-Saxon period there are believed to have been two battles fought in Wednesbury, in 592 and 715. According to The ''Anglo-Saxon Chronicle'' there was "a great slaug ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ernest Starling
Ernest Henry Starling (17 April 1866 – 2 May 1927) was a British physiologist who contributed many fundamental ideas to this subject. These ideas were important parts of the British contribution to physiology, which at that time led the world. He made at least four significant contributions: 1. In the capillary, water is forced out through the pores in the wall by hydrostatic pressure and driven in by the osmotic pressure of plasma proteins (or oncotic pressure). These opposing forces approximately balance; which is known as Starling's Principle. 2. The discovery of the hormone secretinwith his brother-in-law William Baylissand the introduction of the word hormone. 3. The analysis of the heart's activity as a pump, which is known as the Frank–Starling law. 4. Several fundamental observations on the action of the kidneys. These include evidence for the existence of vasopressin, the anti-diuretic hormone. He also wrote the leading textbook of physiology in English, which ran t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Leonard Ernest Bayliss
Leonard Ernest Bayliss (15 November 1900 – 20 August 1964) was an English physiologist. and author. He is known for his work on the physiology of water-relations, including the maintenance of blood volume and kidney functioning. Leonard Bayliss is best known for revising a well-known textbook, ''Principles of general physiology'' in two volumes, that had first been written by his father William Bayliss. He also published ''Human Physiology'', coauthored with F.R. Winton. He developed methods to study blood flow. Bayliss was the son of William Bayliss and Gertrude, the sister of physiologist E.H. Starling. Leonard Bayliss studied at the University College School before going to Trinity College, Cambridge in 1922. He continued for his PhD as a Michael Foster Student and his thesis was on "tone in plain muscle." He was a Sharpey Scholar from 1926 to 1929 and from 1928 he visited University of Pennsylvania on a Rockefeller Fellowship, working on micropuncture techniques to study ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Osmotic Pressure
Osmotic pressure is the minimum pressure which needs to be applied to a solution to prevent the inward flow of its pure solvent across a semipermeable membrane. It is also defined as the measure of the tendency of a solution to take in a pure solvent by osmosis. Potential osmotic pressure is the maximum osmotic pressure that could develop in a solution if it were separated from its pure solvent by a semipermeable membrane. Osmosis occurs when two solutions containing different concentrations of solute are separated by a selectively permeable membrane. Solvent molecules pass preferentially through the membrane from the low-concentration solution to the solution with higher solute concentration. The transfer of solvent molecules will continue until equilibrium is attained. Theory and measurement Jacobus van 't Hoff found a quantitative relationship between osmotic pressure and solute concentration, expressed in the following equation: :\Pi = icRT where \Pi is osmotic p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Starling Equation
The Starling equation describes the net flow of fluid across a semipermeable membrane. It is named after Ernest Starling. It describes the balance between capillary pressure, interstitial pressure, and osmotic pressure. The classic Starling equation has in recent years been revised. The Starling principle of fluid exchange is key to understanding how plasma fluid (solvent) within the bloodstream (intravascular fluid) moves to the space outside the bloodstream (extravascular space). Transendothelial fluid exchange occurs predominantly in the capillaries, and is a process of plasma ultrafiltration across a semi-permeable membrane. It is now appreciated that the ultrafilter is the glycocalyx of the plasma membrane of the endothelium, whose interpolymer spaces function as a system of small pores, radius circa 5 nm. Where the endothelial glycocalyx overlies an inter endothelial cell cleft, the plasma ultrafiltrate may pass to the interstitial space. Some continuous capillari ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gum Arabic
Gum arabic, also known as gum sudani, acacia gum, Arabic gum, gum acacia, acacia, Senegal gum, Indian gum, and by other names, is a natural gum originally consisting of the hardened sap of two species of the '' Acacia'' tree, ''Senegalia senegal'' and ''Vachellia seyal.'' The term "gum arabic" does not legally indicate a particular botanical source, however. The gum is harvested commercially from wild trees, mostly in Sudan (80%) and throughout the Sahel, from Senegal to Somalia. The name "gum Arabic" (''al-samgh al-'arabi'') was used in the Middle East at least as early as the 9th century. Gum arabic first found its way to Europe via Arabic ports, so retained its name. Gum arabic is a complex mixture of glycoproteins and polysaccharides, predominantly polymers of arabinose and galactose. It is soluble in water, edible, and used primarily in the food industry and soft-drink industry as a stabilizer, with E number E414 (I414 in the US). Gum arabic is a key ingredient ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gelatin
Gelatin or gelatine (from la, gelatus meaning "stiff" or "frozen") is a translucent, colorless, flavorless food ingredient, commonly derived from collagen taken from animal body parts. It is brittle when dry and rubbery when moist. It may also be referred to as hydrolyzed collagen, collagen hydrolysate, gelatine hydrolysate, hydrolyzed gelatine, and collagen peptides after it has undergone hydrolysis. It is commonly used as a gelling agent in food, beverages, medications, drug or vitamin capsules, photographic films, papers, and cosmetics. Substances containing gelatin or functioning in a similar way are called gelatinous substances. Gelatin is an irreversibly hydrolyzed form of collagen, wherein the hydrolysis reduces protein fibrils into smaller peptides; depending on the physical and chemical methods of denaturation, the molecular weight of the peptides falls within a broad range. Gelatin is present in gelatin desserts, most gummy candy and marshmallows, ice creams, dips ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Battle Of The Somme
The Battle of the Somme ( French: Bataille de la Somme), also known as the Somme offensive, was a battle of the First World War fought by the armies of the British Empire and French Third Republic against the German Empire. It took place between 1 July and 18 November 1916 on both sides of the upper reaches of the Somme, a river in France. The battle was intended to hasten a victory for the Allies. More than three million men fought in the battle of whom one million were wounded or killed, making it one of the deadliest battles in human history. The French and British had committed themselves to an offensive on the Somme during the Chantilly Conference in December 1915. The Allies agreed upon a strategy of combined offensives against the Central Powers in 1916 by the French, Russian, British and Italian armies, with the Somme offensive as the Franco-British contribution. Initial plans called for the French army to undertake the main part of the Somme offensive, supported on ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Frank–Starling Law
The Frank–Starling law of the heart (also known as Starling's law and the Frank–Starling mechanism) represents the relationship between stroke volume and end diastolic volume.Widmaier, E. P., Hershel, R., & Strang, K. T. (2016).''Vander's Human Physiology: The Mechanisms of Body Function''(14th ed.). New York, NY: McGraw-Hill Education. The law states that the stroke volume of the heart increases in response to an increase in the volume of blood in the ventricles, before contraction (the end diastolic volume), when all other factors remain constant. As a larger volume of blood flows into the ventricle, the blood stretches cardiac muscle, leading to an increase in the force of contraction. The Frank-Starling mechanism allows the cardiac output to be synchronized with the venous return, arterial blood supply and humoral length, without depending upon external regulation to make alterations. The physiological importance of the mechanism lies mainly in maintaining left and right v ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Shock (circulatory)
Shock is the state of insufficient blood flow to the tissues of the body as a result of problems with the circulatory system. Initial symptoms of shock may include weakness, fast heart rate, fast breathing, sweating, anxiety, and increased thirst. This may be followed by confusion, unconsciousness, or cardiac arrest, as complications worsen. Shock is divided into four main types based on the underlying cause: low volume, cardiogenic, obstructive, and distributive shock. Low volume shock, also known as hypovolemic shock, may be from bleeding, diarrhea, or vomiting. Cardiogenic shock may be due to a heart attack or cardiac contusion. Obstructive shock may be due to cardiac tamponade or a tension pneumothorax. Distributive shock may be due to sepsis, anaphylaxis, injury to the upper spinal cord, or certain overdoses. The diagnosis is generally based on a combination of symptoms, physical examination, and laboratory tests. A decreased pulse pressure (systolic blood pressure m ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Brown Dog Affair
The Brown Dog affair was a political controversy about vivisection that raged in Britain from 1903 until 1910. It involved the infiltration of University of London medical lectures by Swedish feminists, battles between medical students and the police, police protection for the statue of a dog, a libel trial at the Royal Courts of Justice, and the establishment of a Royal Commission to investigate the use of animals in experiments. The affair became a that divided the country. The controversy was triggered by allegations that, in February 1903, William Bayliss of the Department of Physiology at University College London performed an illegal vivisection, before an audience of 60 medical students, on a brown terrier dog—adequately anaesthetized, according to Bayliss and his team; conscious and struggling, according to the Swedish activists. The procedure was condemned as cruel and unlawful by the National Anti-Vivisection Society. Outraged by the assault on his reputation, Bayl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hormones
A hormone (from the Ancient Greek, Greek participle , "setting in motion") is a class of cell signaling, signaling molecules in multicellular organisms that are sent to distant organs by complex biological processes to regulate physiology and behavior. Hormones are required for the correct development of animals, plants and fungi. Due to the broad definition of a hormone (as a signaling molecule that exerts its effects far from its site of production), numerous kinds of molecules can be classified as hormones. Among the substances that can be considered hormones, are eicosanoids (e.g. prostaglandins and thromboxanes), steroids (e.g. Estrogen, oestrogen and brassinosteroid), amino acid derivatives (e.g. epinephrine and auxin), protein or peptides (e.g. insulin and CLE peptides), and gases (e.g. ethylene and nitric oxide). Hormones are used to communicate between organ (anatomy), organs and Tissue (biology), tissues. In vertebrates, hormones are responsible for regulating a variety ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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