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William Paul Duprex
William Paul Duprex (pronounced ; born 1968) is a British scientist and advocate for vaccines and global health. He serves as Director of the University of Pittsburgh's Center for Vaccine Research and Regional Biocontainment Laboratory. Duprex holds the Jonas Salk Chair in Vaccine Research. He is also a professor of microbiology and molecular genetics at the University of Pittsburgh School of Medicine and serves as Editor-in-Chief of the ''Journal of General Virology'', which is published by the Microbiology Society, and a senior editor of mSphere, published by the American Society for Microbiology. Duprex is an expert in measles and mumps viruses and studies viral spillover from animals to humans, including the SARS-CoV-2 virus that caused the COVID-19 pandemic. Duprex is a Fellow of the American Academy of Microbiology. Early life and education Duprex, who goes by his middle name, Paul, was born to a Protestant family in Lurgan, Northern Ireland, during the violent p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lurgan, Northern Ireland
Lurgan () is a town in County Armagh, Northern Ireland, near the southern shore of Lough Neagh. Lurgan is about south-west of Belfast and is linked to the city by both the M1 motorway and the Belfast–Dublin railway line. It had a population of about 28,634 (38,198 District Area) at the 2021 UK census and is within the Armagh, Banbridge and Craigavon district. For some purposes, Lurgan is treated as part of the "Craigavon Urban Area" along with neighbouring Craigavon and Portadown. Lurgan is characteristic of many Plantation of Ulster settlements, with its straight, wide planned streets. It is the site of a number of historic listed buildings including Brownlow House and Lurgan Town Hall. Lurgan Park is the largest urban park in Northern Ireland. Historically the town was known as a major centre for the production of textiles (mainly linen) after the Industrial Revolution, and it continued to be a major producer of textiles until that industry steadily declined in the la ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Spillover Infection
Spillover infection, also known as pathogen spillover and spillover event, occurs when a reservoir population with a high pathogen prevalence comes into contact with a novel host population. The pathogen is transmitted from the reservoir population and may or may not be transmitted within the host population. Due to climate change and land use expansion, the risk of viral spillover is predicted to significantly increase. Spillover zoonoses Spillover is a common event; in fact, more than two-thirds of human viruses are zoonotic. Most spillover events result in self-limited cases with no further human to human transmission, as occurs, for example, with rabies, anthrax, histoplasmosis or hidatidosis. Other zoonotic pathogens are able to be transmitted by humans to produce secondary cases and even to establish limited chains of transmission. Some examples are the Ebola and Marburg filoviruses, COVID-19, the MERS and SARS coronaviruses or some avian flu viruses. Finally, some few spil ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Canine Distemper
Canine distemper virus (CDV) (sometimes termed footpad disease) is a viral disease that affects a wide variety of mammal families, including domestic and wild species of dogs, coyotes, foxes, pandas, wolves, ferrets, skunks, raccoons, and felines, as well as pinnipeds, some primates, and a variety of other species. CDV does not affect humans. In canines CDV affects several body systems, including the gastrointestinal and respiratory tracts and the spinal cord and brain. Common symptoms include high fever, eye inflammation and eye/nose discharge, labored breathing and coughing, vomiting and diarrhea, loss of appetite and lethargy, and hardening of nose and footpads. The viral infection can be accompanied by secondary bacterial infections and can present eventual serious neurological symptoms. Canine distemper is caused by a single-stranded RNA virus of the family ''Paramyxoviridae'' (the same family of the viruses that causes measles, mumps, and bronchiolitis in humans). The d ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mumps
MUMPS ("Massachusetts General Hospital Utility Multi-Programming System"), or M, is an imperative, high-level programming language with an integrated transaction processing key–value database. It was originally developed at Massachusetts General Hospital for managing hospital laboratory information systems. MUMPS technology has since expanded as the predominant database for health information systems and electronic health records in the United States. MUMPS-based information systems run over 40% of the hospitals in the U.S., run across all of the U.S. federal hospitals and clinics, and provide health information services for over 54% of patients across the U.S. A unique feature of the MUMPS technology is its integrated database language, allowing direct, high-speed read-write access to permanent disk storage. This provides tight integration of unlimited applications within a single database, and provides extremely high performance and reliability as an online transaction pro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Measles
Measles is a highly contagious infectious disease caused by measles virus. Symptoms usually develop 10–12 days after exposure to an infected person and last 7–10 days. Initial symptoms typically include fever, often greater than , cough, runny nose, and inflamed eyes. Small white spots known as Koplik's spots may form inside the mouth two or three days after the start of symptoms. A red, flat rash which usually starts on the face and then spreads to the rest of the body typically begins three to five days after the start of symptoms. Common complications include diarrhea (in 8% of cases), middle ear infection (7%), and pneumonia (6%). These occur in part due to measles-induced immunosuppression. Less commonly seizures, blindness, or inflammation of the brain may occur. Other names include ''morbilli'', ''rubeola'', ''red measles'', and ''English measles''. Both rubella, also known as ''German measles'', and roseola are different diseases caused by unrelated viruses. Mea ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Molecular Virology
Virology is the scientific study of biological viruses. It is a subfield of microbiology that focuses on their detection, structure, classification and evolution, their methods of infection and exploitation of host cells for reproduction, their interaction with host organism physiology and immunity, the diseases they cause, the techniques to isolate and culture them, and their use in research and therapy. The identification of the causative agent of tobacco mosaic disease (TMV) as a novel pathogen by Martinus Beijerinck (1898) is now acknowledged as being the official beginning of the field of virology as a discipline distinct from bacteriology. He realized the source was neither a bacterial nor a fungal infection, but something completely different. Beijerinck used the word "virus" to describe the mysterious agent in his 'contagium vivum fluidum' ('contagious living fluid'). Rosalind Franklin proposed the full structure of the tobacco mosaic virus in 1955. Virology began when ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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