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White Collar-2
The ''white collar-''-2 (''wc-''2) gene in ''Neurospora crassa'' encodes the protein White Collar-2 (WC-2). WC-2 is a GATA transcription factor necessary for blue light photoreception and for regulating circadian rhythms in ''Neurospora''. In both contexts, WC-2 binds to its non-Gene redundancy, redundant counterpart White Collar-1 (WC-1) through PAS domains to form the White Collar Complex (WCC), an active transcription factor. The WCC has two major and distinct roles in the cell. In the light, the WCC acts as a photoreceptor to mediate acute regulation of light-induced genes involved in various physiological processes such as carotenoid (type of pigment) biosynthesis and conidiation. In a separate and distinct role in the dark, WCC acts as the positive element in the autoregulatory transcription-translation negative feedback loop that controls circadian rhythmic behaviors in ''Neurospora''. In this context, WCC regulates expression of the frequency (gene), Frequency (FRQ) gene, a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neurospora Crassa
''Neurospora crassa'' is a type of red bread mold of the phylum Ascomycota. The genus name, meaning "nerve spore" in Greek, refers to the characteristic striations on the spores. The first published account of this fungus was from an infestation of French bakeries in 1843. ''Neurospora crassa'' is used as a model organism because it is easy to grow and has a haploid life cycle that makes genetics, genetic analysis simple since recessive traits will show up in the offspring. Analysis of genetic recombination is facilitated by the ordered arrangement of the products of meiosis in ''Neurospora'' ascospores. Its entire genome of seven chromosomes has been sequenced. ''Neurospora'' was used by Edward Tatum and George Wells Beadle in their experiments for which they won the Nobel Prize in Physiology or Medicine in 1958. Beadle and Tatum exposed ''N. crassa'' to x-rays, causing mutations. They then observed failures in metabolic pathways caused by errors in specific enzymes. This led t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
