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Wellcome Centre For Human Genetics
The Wellcome Centre for Human Genetics is a human genetics research centre of the Nuffield Department of Medicine in the Medical Sciences Division, University of Oxford, funded by the Wellcome Trust among others. Facilities & resources The centre is located at the Henry Wellcome Building of Genomic Medicine, which cost £20 million and was officially opened in June 2000 with Anthony Monaco as the director. Within the WHG a number of 'cores' provide services to the researchers: Oxford Genomics Centre The Oxford Genomics Centre provides high throughput sequencing services, using Illumina HiSeq4000 2500 and NextSeq500 and MiSeq. They also offer Oxford Nanopore MinION and PromethION sequencing. There are also Array platforms for genotyping, gene expression, and methylation including Illuminia Infinium, Affymetrix and Fluidigm. Research Computing Core The Research Computing Core provides access to computer resources including 4120 cores and 4.2 PB of storage. Transgenics ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
John Todd (British Biologist)
John is a common English name and surname: * John (given name) * John (surname) John may also refer to: New Testament Works * Gospel of John, a title often shortened to John * First Epistle of John, often shortened to 1 John * Second Epistle of John, often shortened to 2 John * Third Epistle of John, often shortened to 3 John People * John the Baptist (died c. AD 30), regarded as a prophet and the forerunner of Jesus Christ * John the Apostle (lived c. AD 30), one of the twelve apostles of Jesus * John the Evangelist, assigned author of the Fourth Gospel, once identified with the Apostle * John of Patmos, also known as John the Divine or John the Revelator, the author of the Book of Revelation, once identified with the Apostle * John the Presbyter, a figure either identified with or distinguished from the Apostle, the Evangelist and John of Patmos Other people with the given name Religious figures * John, father of Andrew the Apostle and Saint Peter * Pope J ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Total Internal Reflection Microscopy
Total internal reflection microscopy is a specialized optical imaging technique for object tracking and detection utilizing the light scattered from an evanescent field in the vicinity of a dielectric interface. Its advantages are a high signal-to-noise ratio and a high spatial resolution in the vertical dimension. Background Total internal reflection of light occurs at the interface between materials of differing indices of refraction at incident angles greater than the critical angle, \theta_c, where :\theta_c = \sin^(n_2/n_1) and n_1 is the index of the incident medium and n_2 the index of the transmission medium and \theta_c is measured from the normal to the interface. Under conditions of total internal reflection, the electromagnetic field in the transmission medium takes on the form of an evanescent wave, whose intensity I(z) decays exponentially with distance from the interface such that, :I(z) = I_0 e^ with \beta = \frac\sqrt. For practical purposes, the transmission ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Research Institutes In Oxford
Research is " creative and systematic work undertaken to increase the stock of knowledge". It involves the collection, organization and analysis of evidence to increase understanding of a topic, characterized by a particular attentiveness to controlling sources of bias and error. These activities are characterized by accounting and controlling for biases. A research project may be an expansion on past work in the field. To test the validity of instruments, procedures, or experiments, research may replicate elements of prior projects or the project as a whole. The primary purposes of basic research (as opposed to applied research) are documentation, discovery, interpretation, and the research and development (R&D) of methods and systems for the advancement of human knowledge. Approaches to research depend on epistemologies, which vary considerably both within and between humanities and sciences. There are several forms of research: scientific, humanities, artistic, econom ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genetics Or Genomics Research Institutions
Genetics is the study of genes, genetic variation, and heredity in organisms.Hartl D, Jones E (2005) It is an important branch in biology because heredity is vital to organisms' evolution. Gregor Mendel, a Moravian Augustinians, Augustinian friar working in the 19th century in Brno, was the first to study genetics scientifically. Mendel studied "trait inheritance", patterns in the way traits are handed down from parents to offspring over time. He observed that organisms (pea plants) inherit traits by way of discrete "units of inheritance". This term, still used today, is a somewhat ambiguous definition of what is referred to as a gene. Phenotypic trait, Trait inheritance and Molecular genetics, molecular inheritance mechanisms of genes are still primary principles of genetics in the 21st century, but modern genetics has expanded to study the function and behavior of genes. Gene structure and function, variation, and distribution are studied within the context of the Cell (biolo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genetics In The United Kingdom
Genetics is the study of genes, genetic variation, and heredity in organisms.Hartl D, Jones E (2005) It is an important branch in biology because heredity is vital to organisms' evolution. Gregor Mendel, a Moravian Augustinian friar working in the 19th century in Brno, was the first to study genetics scientifically. Mendel studied "trait inheritance", patterns in the way traits are handed down from parents to offspring over time. He observed that organisms (pea plants) inherit traits by way of discrete "units of inheritance". This term, still used today, is a somewhat ambiguous definition of what is referred to as a gene. Trait inheritance and molecular inheritance mechanisms of genes are still primary principles of genetics in the 21st century, but modern genetics has expanded to study the function and behavior of genes. Gene structure and function, variation, and distribution are studied within the context of the cell, the organism (e.g. dominance), and within the context ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Educational Institutions Established In 1994
Education is a purposeful activity directed at achieving certain aims, such as transmitting knowledge or fostering skills and character traits. These aims may include the development of understanding, rationality, kindness, and honesty. Various researchers emphasize the role of critical thinking in order to distinguish education from indoctrination. Some theorists require that education results in an improvement of the student while others prefer a value-neutral definition of the term. In a slightly different sense, education may also refer, not to the process, but to the product of this process: the mental states and dispositions possessed by educated people. Education originated as the transmission of cultural heritage from one generation to the next. Today, educational goals increasingly encompass new ideas such as the liberation of learners, skills needed for modern society, empathy, and complex vocational skills. Types of education are commonly divided into formal ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Departments Of The University Of Oxford
The various academic faculties, departments, and institutes of the University of Oxford are organised into four divisions, each with its own Head and elected board. They are the Humanities Division; the Social Sciences Division; the Mathematical, Physical and Life Sciences Division; and the Medical Sciences Division. Humanities Division The Humanities Division has received considerable praise for its work at the forefront of digitising the Humanities. The Humanities Division has been physically expanding into the new Radcliffe Observatory Quarter in Oxford. The current Head of the Humanities Division is Professor Karen O'Brien. Professor Sally Shuttleworth was Head from 2006 to 2011, Professor Shearer West served as Head between August 2011 and 2015, and Chris Wickham until 2018. The Division contains the following faculties and departments: * Rothermere American Institute * Ruskin School of Art * Faculty of Classics * Faculty of English * Faculty of History * History of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biotechnology In The United Kingdom
Biotechnology in the United Kingdom is the British industry regarding organisms that manufacture commercial products, whether the genes of the organism have been naturally procured or not (synthetic biology). The industry can be controversial, and often overlaps with the healthcare Health care or healthcare is the improvement of health via the prevention, diagnosis, treatment, amelioration or cure of disease, illness, injury, and other physical and mental impairments in people. Health care is delivered by health profe ... and Pharmaceutical industry in the United Kingdom, pharmaceutical industry (biopharmaceuticals). Currently, most industrial biotechnology expenditure in the UK is in the field of healthcare, and consequently the UK is the leader in Europe in the development of biopharmaceuticals, by some distance. History Celtech, founded in 1980, was one of the earliest British biotechs. In 2015, the UK had around 225 main biotechnology companies, turning over around ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1994 Establishments In England
File:1994 Events Collage.png, From left, clockwise: The 1994 Winter Olympics are held in Lillehammer, Norway; The Kaiser Permanente building after the 1994 Northridge earthquake; A model of the MS Estonia, which sank in the Baltic Sea; Nelson Mandela casts his vote in the 1994 South African general election, in which he was elected South Africa's first president, and which effectively brought Apartheid to an end; NAFTA, which was signed in 1992, comes into effect in Canada, the United States, and Mexico; The first passenger rail service to utilize the newly-opened Channel tunnel; The 1994 FIFA World Cup is held in the United States; Skulls from the Rwandan genocide, in which over half a million Tutsi people were massacred by Hutus., 300x300px, thumb rect 0 0 200 200 1994 Winter Olympics rect 200 0 400 200 Northridge earthquake rect 400 0 600 200 Sinking of the MS Estonia rect 0 200 300 400 Rwandan genocide rect 300 200 600 400 Nelson Mandela rect 0 400 200 600 1994 FI ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
International HapMap Project
The International HapMap Project was an organization that aimed to develop a haplotype map (HapMap) of the human genome, to describe the common patterns of human genetic variation. HapMap is used to find genetic variants affecting health, disease and responses to drugs and environmental factors. The information produced by the project is made freely available for research. The International HapMap Project is a collaboration among researchers at academic centers, non-profit biomedical research groups and private companies in Canada, China (including Hong Kong), Japan, Nigeria, the United Kingdom, and the United States. It officially started with a meeting on October 27 to 29, 2002, and was expected to take about three years. It comprises two phases; the complete data obtained in Phase I were published on 27 October 2005. The analysis of the Phase II dataset was published in October 2007. The Phase III dataset was released in spring 2009 and the publication presenting the final resul ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1000 Genomes Project
The 1000 Genomes Project (abbreviated as 1KGP), launched in January 2008, was an international research effort to establish by far the most detailed catalogue of human genetic variation. Scientists planned to sequence the genomes of at least one thousand anonymous participants from a number of different ethnic groups within the following three years, using newly developed technologies which were faster and less expensive. In 2010, the project finished its pilot phase, which was described in detail in a publication in the journal ''Nature''. In 2012, the sequencing of 1092 genomes was announced in a ''Nature'' publication. In 2015, two papers in ''Nature'' reported results and the completion of the project and opportunities for future research. Many rare variations, restricted to closely related groups, were identified, and eight structural-variation classes were analyzed. The project unites multidisciplinary research teams from institutes around the world, including China, Ita ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Single-particle Tracking
Single-particle tracking (SPT) is the observation of the motion of individual particles within a medium. The coordinates time series, which can be either in two dimensions (''x'', ''y'') or in three dimensions (''x'', ''y'', ''z''), is referred to as a ''trajectory''. The trajectory is typically analyzed using statistical methods to extract information about the underlying dynamics of the particle. These dynamics can reveal information about the type of transport being observed (e.g., thermal or active), the medium where the particle is moving, and interactions with other particles. In the case of random motion, trajectory analysis can be used to measure the diffusion coefficient. Applications In life sciences, single-particle tracking is broadly used to quantify the dynamics of molecules/proteins in live cells (of bacteria, yeast, mammalian cells and live ''Drosophila'' embryos). It has been extensively used to study the transcription factor dynamics in live cells. This method h ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
