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Wafik El-Deiry
Wafik El-Deiry (born, 1961) is an American physician and cancer researcher who is the Associate Dean for Oncologic Sciences at the Warren Alpert Medical School, Brown University, Director of the Cancer Center at Brown University, and the Director of the Joint Program in Cancer Biology at Brown University and its affiliated hospitals. He was previously deputy director of Translational Research at Fox Chase Cancer Center, where he was also co-Leader of the Molecular Therapeutics Program. Career El-Deiry was formerly a professor of Medicine and Chief of Hematology/Oncology at the Penn State Milton S. Hershey Medical Center. He also served as the associate director for Translational Research and Interim Cancer Center Director at Penn State University. Prior to his tenure at Penn State, he was an investigator in cell biology at the Howard Hughes Medical Institute and a professor of medicine, genetics, and pharmacology at the University of Pennsylvania School of Medicine. While at t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Warren Alpert Medical School
The Warren Alpert Medical School (formerly known as Brown Medical School, previously known as Brown University School of Medicine) is the medical school of Brown University, located in Providence, Rhode Island. Originally established in 1811, it was the third medical school to be founded in New England after only Harvard and Dartmouth. However, the original program was suspended in 1827, and the four-year medical program was re-established almost 150 years later in 1972, granting the first MD degrees in 1975. Today, the Warren Alpert Medical School is a component of Brown’s Division of Biology and Medicine, which also includes the Program in Biology. Together with the Medical School’s seven affiliated teaching hospitals, the Division attracts over $300 million in external research funding per year. Alpert Medical School earned ranked 14th for primary care education and 35th for research in the 2023 ''U.S. News & World Report'' rankings, and was ranked among the top 25 medic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Abemaciclib
Abemaciclib, sold under the brand name Verzenio among others, is a medication for the treatment of advanced or metastatic breast cancers. It was developed by Eli Lilly and it acts as a CDK inhibitor selective for CDK4 and CDK6. It was designated as a breakthrough therapy for breast cancer by the U.S. Food and Drug Administration (FDA) in October 2015. On 28 September 2017, it was approved for use in the United States by the FDA for the treatment of certain breast cancers. Medical uses Since September 2017 Abemaciclib is approved in the US for "adult patients who have hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced or metastatic breast cancer that has progressed after taking therapy that alters a patient's hormones". In studies that compared fulvestrant plus abemaciclib to fulvestrant plus placebo in breast cancer patients, progression-free survival under abemaciclib therapy was 16.4 months on average, as compared to 9.3 month ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ONC201
A trail, also known as a path or track, is an unpaved lane or small road usually passing through a natural area. In the United Kingdom and the Republic of Ireland, a path or footpath is the preferred term for a pedestrian or hiking trail. The term is also applied in North America to routes along rivers, and sometimes to highways. In the US, the term was historically used for a route into or through wild territory used by explorers and migrants (e.g. the Oregon Trail). In the United States, "trace" is a synonym for trail, as in Natchez Trace. Some trails are dedicated only for walking, cycling, horse riding, snowshoeing or cross-country skiing, but not more than one use; others, as in the case of a bridleway in the UK, are multi-use and can be used by walkers, cyclists and equestrians alike. There are also unpaved trails used by dirt bikes and other off-road vehicles, and in some places, like the Alps, trails are used for moving cattle and other livestock. Usage In ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sorafenib
Sorafenib, sold under the brand name Nexavar, is a kinase inhibitor drug approved for the treatment of primary kidney cancer (advanced renal cell carcinoma), advanced primary liver cancer ( hepatocellular carcinoma), FLT3-ITD positive AML and radioactive iodine resistant advanced thyroid carcinoma. Mechanism of action Sorafenib is a protein kinase inhibitor with activity against many protein kinases, including VEGFR, PDGFR and RAF kinases. Of the RAF kinases, sorafenib is more selective for c-Raf than B-RAF. (See BRAF (gene)#Sorafenib for details the drug's interaction with B-Raf.) Sorafenib treatment induces autophagy, which may suppress tumor growth. Based on its 1,3-disubstituted urea structure, sorafenib is also a potent soluble epoxide hydrolase inhibitor and this activity likely reduces the severity of its adverse effects. Medical uses Sorafenib is indicated as a treatment for advanced renal cell carcinoma (RCC), unresectable hepatocellular carcinomas (HCC) and thy ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
TRAIL
A trail, also known as a path or track, is an unpaved lane or small road usually passing through a natural area. In the United Kingdom and the Republic of Ireland, a path or footpath is the preferred term for a pedestrian or hiking trail. The term is also applied in North America to routes along rivers, and sometimes to highways. In the US, the term was historically used for a route into or through wild territory used by explorers and migrants (e.g. the Oregon Trail). In the United States, "trace" is a synonym for trail, as in Natchez Trace. Some trails are dedicated only for walking, cycling, horse riding, snowshoeing or cross-country skiing, but not more than one use; others, as in the case of a bridleway in the UK, are multi-use and can be used by walkers, cyclists and equestrians alike. There are also unpaved trails used by dirt bikes and other off-road vehicles, and in some places, like the Alps, trails are used for moving cattle and other livestock. Usage In Austra ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cell Death
Cell death is the event of a biological cell ceasing to carry out its functions. This may be the result of the natural process of old cells dying and being replaced by new ones, as in programmed cell death, or may result from factors such as diseases, localized injury, or the death of the organism of which the cells are part. Apoptosis or Type I cell-death, and autophagy or Type II cell-death are both forms of programmed cell death, while necrosis is a non-physiological process that occurs as a result of infection or injury. Programmed cell death Programmed cell death (PCD) is cell death mediated by an intracellular program. PCD is carried out in a regulated process, which usually confers advantage during an organism's life-cycle. For example, the differentiation of fingers and toes in a developing human embryo occurs because cells between the fingers apoptose; the result is that the digits separate. PCD serves fundamental functions during both plant and metazoa (multicellula ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Karen Vousden
Karen Heather Vousden, CBE, FRS, FRSE, FMedSci (born 19 July 1957) is a British medical researcher. She is known for her work on the tumour suppressor protein, p53, and in particular her discovery of the important regulatory role of Mdm2, an attractive target for anti-cancer agents. From 2003 to 2016, she was the director of the Cancer Research UK Beatson Institute in Glasgow, UK, moving back to London in 2016 to take up the role of Chief Scientist at CRUK and Group Leader at the Francis Crick Institute. Education After attending Gravesend Grammar School for Girls, Vousden gained a Bachelor of Science degree in genetics and microbiology (1978) and a PhD from Queen Mary College, University of London on the use of suppressor gene mutations to study transfer RNA redundancy in the fungus ''Coprinus''. [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Scott W
Scott may refer to: Places Canada * Scott, Quebec, municipality in the Nouvelle-Beauce regional municipality in Quebec * Scott, Saskatchewan, a town in the Rural Municipality of Tramping Lake No. 380 * Rural Municipality of Scott No. 98, Saskatchewan United States * Scott, Arkansas * Scott, Georgia * Scott, Indiana * Scott, Louisiana * Scott, Missouri * Scott, New York * Scott, Ohio * Scott, Wisconsin (other) (several places) * Fort Scott, Kansas * Great Scott Township, St. Louis County, Minnesota * Scott Air Force Base, Illinois * Scott City, Kansas * Scott City, Missouri * Scott County (other) (various states) * Scott Mountain, a mountain in Oregon * Scott River, in California * Scott Township (other) (several places) Elsewhere * 876 Scott, minor planet orbiting the Sun * Scott (crater), a lunar impact crater near the south pole of the Moon *Scott Conservation Park, a protected area in South Australia People * Scott (surname), including a list ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Michael B
Michael may refer to: People * Michael (given name), a given name * Michael (surname), including a list of people with the surname Michael Given name "Michael" * Michael (archangel), ''first'' of God's archangels in the Jewish, Christian and Islamic religions * Michael (bishop elect), English 13th-century Bishop of Hereford elect * Michael (Khoroshy) (1885–1977), cleric of the Ukrainian Orthodox Church of Canada * Michael Donnellan (1915–1985), Irish-born London fashion designer, often referred to simply as "Michael" * Michael (footballer, born 1982), Brazilian footballer * Michael (footballer, born 1983), Brazilian footballer * Michael (footballer, born 1993), Brazilian footballer * Michael (footballer, born February 1996), Brazilian footballer * Michael (footballer, born March 1996), Brazilian footballer * Michael (footballer, born 1999), Brazilian footballer Rulers =Byzantine emperors= *Michael I Rangabe (d. 844), married the daughter of Emperor Nikephoros I * Mi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Apoptosis
Apoptosis (from grc, ἀπόπτωσις, apóptōsis, 'falling off') is a form of programmed cell death that occurs in multicellular organisms. Biochemical events lead to characteristic cell changes (morphology) and death. These changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation, DNA fragmentation, and mRNA decay. The average adult human loses between 50 and 70 billion cells each day due to apoptosis. For an average human child between eight and fourteen years old, approximately twenty to thirty billion cells die per day. In contrast to necrosis, which is a form of traumatic cell death that results from acute cellular injury, apoptosis is a highly regulated and controlled process that confers advantages during an organism's life cycle. For example, the separation of fingers and toes in a developing human embryo occurs because cells between the digits undergo apoptosis. Unlike necrosis, apoptosis produces cell fragments called apoptotic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Death Receptor 5
Death receptor 5 (DR5), also known as TRAIL receptor 2 (TRAILR2) and tumor necrosis factor receptor superfamily member 10B (TNFRSF10B), is a cell surface receptor of the TNF-receptor superfamily that binds TRAIL and mediates apoptosis. Function The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces apoptosis signal. Mice have a homologous gene, tnfrsf10b, that has been essential in the elucidation of the function of this gene in humans. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Interactions DR5 has been shown to interact with: * Caspase 8, * Caspase 10, * FADD, and * TRAIL. Cancer therapy Monoclonal antibodies targeting DR5 have been developed and are currently under c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American Cancer Society
The American Cancer Society (ACS) is a nationwide voluntary health organization dedicated to eliminating cancer. Established in 1913, the society is organized into six geographical regions of both medical and lay volunteers operating in more than 250 Regional offices throughout the United States. Its global headquarters is located in the American Cancer Society Center in Atlanta, Georgia. The ACS publishes the journals ''Cancer'', '' CA: A Cancer Journal for Clinicians'' and ''Cancer Cytopathology''. History The society was founded on May 22, 1913, by ten physicians and five businessmen in New York City under the name "American Society for the Control of Cancer" (ASCC). The current name was adopted in 1944. At the time of founding, it was not considered appropriate to mention the word "cancer" in public. Information concerning this illness was cloaked in a climate of fear and denial. Over 75,000 people died each year of cancer in just the United States. The top item on the foun ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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