|
Virtual Fly Brain
Virtual Fly Brain, or VFB, is an interactive, web-based tool that allows neurobiologists to explore the detailed neuroanatomy, transgene expression and associated phenotypes of the ''Drosophila melanogaster'' brain. Users can browse painted 3D image stacks of the ''Drosophila'' brain, choosing any plane of section they want and clicking on painted regions to find names' definitions, references and synonyms for the chosen region. For each region, they can run queries to find neurons, transgene expression and phenotypes. For each neuron found, users can browse definitions, references and synonyms. Background Virtual Fly Brain is a generic web-based application that allows browsing of 3D image stacks and querying of the underlying anatomy and expression database that is maintained by FlyBase. ThVirtual Fly Brainproject is carried out by researchers at the University of Cambridge and the University of Edinburgh. Technical details Virtual Fly Brain uses an ontological model of ''Dr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Web Ontology Language
The Web Ontology Language (OWL) is a family of knowledge representation languages for authoring ontologies. Ontologies are a formal way to describe taxonomies and classification networks, essentially defining the structure of knowledge for various domains: the nouns representing classes of objects and the verbs representing relations between the objects. Ontologies resemble class hierarchies in object-oriented programming but there are several critical differences. Class hierarchies are meant to represent structures used in source code that evolve fairly slowly (perhaps with monthly revisions) whereas ontologies are meant to represent information on the Internet and are expected to be evolving almost constantly. Similarly, ontologies are typically far more flexible as they are meant to represent information on the Internet coming from all sorts of heterogeneous data sources. Class hierarchies on the other hand tend to be fairly static and rely on far less diverse and more structu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pigment Dispersing Factor
''Pigment dispersing factor'' (''pdf'') is a gene that encodes the protein PDF, which is part of a large family of neuropeptides. Its hormonal product, pigment dispersing hormone (PDH), was named for the diurnal pigment movement effect it has in crustacean retinal cells upon its initial discovery in the central nervous system of arthropods. The movement and aggregation of pigments in retina cells and extra-retinal cells is hypothesized to be under a split hormonal control mechanism. One hormonal set is responsible for concentrating chromatophoral pigment by responding to changes in the organism's exposure time to darkness. Another hormonal set is responsible for dispersion and responds to the light cycle. However, insect ''pdf'' genes do not function in such pigment migration since they lack the chromatophore.The Interactive Fl2011 Apr 28. The gene was first isolated and studied in '' Drosophila melanogaster, Drosophila'' by Jeffrey C. Hall's laboratory at Brandeis University ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ganglion Mother Cell
Ganglion mother cells (GMCs) are cells involved in neurogenesis, in non-mammals, that divide only once to give rise to two neurons, or one neuron and one glial cell or two glial cells, and are present only in the central nervous system. They are also responsible for transcription factor expression. While each ganglion mother cell necessarily gives rise to two neurons, a neuroblast can asymmetrically divide multiple times.Doe, C. Q. et al (2008). Identification of Drosophila type II neuroblast lineages containing transit amplifying ganglion mother cells. {{PMC, 2804867. GMCs are the progeny of type I neuroblasts. Neuroblasts asymmetrically divide during embryogenesis to create GMCs.Doe, C. Q. (1992). Molecular markers for identified neuroblasts and ganglion mother cells in the Drosophila central nervous system. Development, 116(4), 855-863. GMCs are only present in certain species and only during the embryonic and larval stages of life. Recent research has shown that there is an int ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Drosophila Connectome
The ''Drosophila'' connectome, once completed, will be a complete list of the roughly 135,000 neurons in the brain of the fruit fly ''Drosophila melanogaster'', along with all of the connections (synapses) between these neurons. As of 2020, the ''Drosophila'' connectome is a work in progress, being obtained by the methods of neural circuit reconstruction. A stack of EM images of an entire brain exist, suitable for sparse tracing of specific circuits. A full connectome of a large portion of the central brain is likewise available. Many of the 76 compartments of the ''Drosophila'' brain have connectomes available, and the remainders are subjects of ongoing study. Why ''Drosophila'' Connectome research (connectomics) has a number of competing objectives. On the one hand, investigators prefer an organism small enough that the connectome can be obtained in a reasonable amount of time. This argues for a small creature. On the other hand, one of the main uses of a connectome is to relat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Insect Brain
The supraesophageal ganglion (also "supraoesophageal ganglion", "arthropod brain" or "microbrain") is the first part of the arthropod, especially insect, central nervous system. It receives and processes information from the first, second, and third Metamerism (biology), metameres. The supraesophageal ganglion lies Dorsum (anatomy), dorsal to the esophagus and consists of three parts, each a pair of ganglia that may be more or less pronounced, reduced, or fused depending on the genus (biology), genus: * The ''protocerebrum'', associated with the arthropod eye, eyes (Eye#Compound eyes, compound eyes and ocelli). Directly associated with the eyes is the optic lobe (arthropod), optic lobe, as the visual center of the brain. * The ''deutocerebrum'' processes sensory information from the Antenna (biology), antennae. It consists of two parts, the antennal lobe and the dorsal lobe. The dorsal lobe also contains motor neurons which control the antennal muscles. * The ''tritocerebrum'' in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
GitHub
GitHub, Inc. () is an Internet hosting service for software development and version control using Git. It provides the distributed version control of Git plus access control, bug tracking, software feature requests, task management, continuous integration, and wikis for every project. Headquartered in California, it has been a subsidiary of Microsoft since 2018. It is commonly used to host open source software development projects. As of June 2022, GitHub reported having over 83 million developers and more than 200 million repositories, including at least 28 million public repositories. It is the largest source code host . History GitHub.com Development of the GitHub.com platform began on October 19, 2007. The site was launched in April 2008 by Tom Preston-Werner, Chris Wanstrath, P. J. Hyett and Scott Chacon after it had been made available for a few months prior as a beta release. GitHub has an annual keynote called GitHub Universe. Organizational ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
FlyBase
FlyBase is an online bioinformatics database and the primary repository of genetic and molecular data for the insect family Drosophilidae. For the most extensively studied species and model organism, ''Drosophila melanogaster'', a wide range of data are presented in different formats. Information in FlyBase originates from a variety of sources ranging from large-scale genome projects to the primary research literature. These data types include mutant phenotypes; molecular characterization of mutant alleles; and other deviations, cytological maps, wild-type expression patterns, anatomical images, transgenic constructs and insertions, sequence-level gene models, and molecular classification of gene product functions. Query tools allow navigation of FlyBase through DNA or protein sequence, by gene or mutant name, or through terms from the several ontologies used to capture functional, phenotypic, and anatomical data. The database offers several different query tools in order to prov ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
OWL-DL
The Web Ontology Language (OWL) is a family of knowledge representation languages for authoring ontologies. Ontologies are a formal way to describe taxonomies and classification networks, essentially defining the structure of knowledge for various domains: the nouns representing classes of objects and the verbs representing relations between the objects. Ontologies resemble class hierarchies in object-oriented programming but there are several critical differences. Class hierarchies are meant to represent structures used in source code that evolve fairly slowly (perhaps with monthly revisions) whereas ontologies are meant to represent information on the Internet and are expected to be evolving almost constantly. Similarly, ontologies are typically far more flexible as they are meant to represent information on the Internet coming from all sorts of heterogeneous data sources. Class hierarchies on the other hand tend to be fairly static and rely on far less diverse and more struct ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Drosophila Anatomy Ontology Link
''Drosophila'' () is a genus of flies, belonging to the family Drosophilidae, whose members are often called "small fruit flies" or (less frequently) pomace flies, vinegar flies, or wine flies, a reference to the characteristic of many species to linger around overripe or rotting fruit. They should not be confused with the Tephritidae, a related family, which are also called fruit flies (sometimes referred to as "true fruit flies"); tephritids feed primarily on unripe or ripe fruit, with many species being regarded as destructive agricultural pests, especially the Mediterranean fruit fly. One species of ''Drosophila'' in particular, ''D. melanogaster'', has been heavily used in research in genetics and is a common model organism in developmental biology. The terms "fruit fly" and "''Drosophila''" are often used synonymously with ''D. melanogaster'' in modern biological literature. The entire genus, however, contains more than 1,500 species and is very diverse in appearance, b ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ontology (information Science)
In computer science and information science, an ontology encompasses a representation, formal naming, and definition of the categories, properties, and relations between the concepts, data, and entities that substantiate one, many, or all domains of discourse. More simply, an ontology is a way of showing the properties of a subject area and how they are related, by defining a set of concepts and categories that represent the subject. Every academic discipline or field creates ontologies to limit complexity and organize data into information and knowledge. Each uses ontological assumptions to frame explicit theories, research and applications. New ontologies may improve problem solving within that domain. Translating research papers within every field is a problem made easier when experts from different countries maintain a controlled vocabulary of jargon between each of their languages. For instance, the definition and ontology of economics is a primary concern in Marxist econo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neurobiologist
A neuroscientist (or neurobiologist) is a scientist who has specialised knowledge in neuroscience, a branch of biology that deals with the physiology, biochemistry, psychology, anatomy and molecular biology of neurons, neural circuits, and glial cells and especially their behavioral, biological, and psychological aspect in health and disease. Neuroscientists generally work as researchers within a college, university, government agency, or private industry setting. In research-oriented careers, neuroscientists typically spend their time designing and carrying out scientific experiments that contribute to the understanding of the nervous system and its function. They can engage in basic or applied research. Basic research seeks to add information to our current understanding of the nervous system, whereas applied research seeks to address a specific problem, such as developing a treatment for a neurological disorder. Biomedically-oriented neuroscientists typically engage in applie ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
