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Virginia Minnich
Virginia Minnich (1910–1996) was an American molecular biologist and hematology researcher known for discovering hemoglobin E, an abnormal form of hemoglobin that can cause blood disorders, and for working out the glutathione synthesis pathway. She was a noted blood morphologist and teacher and helped set up hematology laboratories around the world. She was the first person without a PhD or MD to be appointed a Professor of Medicine at Washington University School of Medicine. Early life and education Minnich was born on January 24, 1910, in Zanesville, Ohio, and raised on her family's farm. She suffered severe burns at the age of four when her dress caught fire from a gas stove and she underwent close to thirty operations to correct the resultant disfigurement. Despite the surgeries, she was left with considerable scarring to her face, neck, and upper body that led some colleagues to discourage her from jobs requiring much human interaction. She had wanted to become a nurse ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Zanesville, Ohio
Zanesville is a city in and the county seat of Muskingum County, Ohio, United States. It is located east of Columbus and had a population of 24,765 as of the 2020 census, down from 25,487 as of the 2010 census. Historically the state capital of Ohio, Zanesville anchors the Zanesville micropolitan statistical area (population 86,183), and is part of the greater Columbus-Marion-Zanesville combined statistical area. History Zanesville was named after Ebenezer Zane (1747–1811), who had blazed Zane's Trace, a pioneer trail from Wheeling, Virginia (now in West Virginia) to Maysville, Kentucky through present-day Ohio. In 1797, he remitted land as payment to his son-in-law, John McIntire (1759–1815), at the point where Zane's Trace met the Muskingum River. With the assistance of Zane, McIntire platted the town, opened an inn and ferry by 1799. In 1801, Zanesville was officially renamed, formerly Westbourne, the chosen name for the settlement by Zane. From 1810 to 1812, th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hemoglobinopathy
Hemoglobinopathy is the medical term for a group of inherited blood disorders and diseases that primarily affect red blood cells. They are single-gene disorders and, in most cases, they are inherited as autosomal co-dominant traits. There are two main groups: abnormal structural hemoglobin variants caused by mutations in the hemoglobin genes, and the thalassemias, which are caused by an underproduction of otherwise normal hemoglobin molecules. The main structural hemoglobin variants are HbS, HbE and HbC. The main types of thalassemia are alpha-thalassemia and beta thalassemia. The two conditions may overlap because some conditions which cause abnormalities in hemoglobin proteins also affect their production. Some hemoglobin variants do not cause pathology or anemia, and thus are often not classed as hemoglobinopathies. Hemoglobin structural biology Normal human hemoglobins are tetrameric proteins composed of two pairs of globin chains, each of which contains one alpha-lik ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Women Molecular Biologists
A woman is an adult female human. Prior to adulthood, a female human is referred to as a girl (a female child or adolescent). The plural ''women'' is sometimes used in certain phrases such as "women's rights" to denote female humans regardless of age. Typically, women inherit a pair of X chromosomes, one from each parent, and are capable of pregnancy and giving birth from puberty until menopause. More generally, sex differentiation of the female fetus is governed by the lack of a present, or functioning, SRY-gene on either one of the respective sex chromosomes. Female anatomy is distinguished from male anatomy by the female reproductive system, which includes the ovaries, fallopian tubes, uterus, vagina, and vulva. A fully developed woman generally has a wider pelvis, broader hips, and larger breasts than an adult man. Women have significantly less facial and other body hair, have a higher body fat composition, and are on average shorter and less muscular than men. Througho ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American Women Biologists
American(s) may refer to: * American, something of, from, or related to the United States of America, commonly known as the "United States" or "America" ** Americans, citizens and nationals of the United States of America ** American ancestry, people who self-identify their ancestry as "American" ** American English, the set of varieties of the English language native to the United States ** Native Americans in the United States, indigenous peoples of the United States * American, something of, from, or related to the Americas, also known as "America" ** Indigenous peoples of the Americas * American (word), for analysis and history of the meanings in various contexts Organizations * American Airlines, U.S.-based airline headquartered in Fort Worth, Texas * American Athletic Conference, an American college athletic conference * American Recordings (record label), a record label previously known as Def American * American University, in Washington, D.C. Sports teams Soccer * Ba ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American Biologists
American(s) may refer to: * American, something of, from, or related to the United States of America, commonly known as the "United States" or "America" ** Americans, citizens and nationals of the United States of America ** American ancestry, people who self-identify their ancestry as "American" ** American English, the set of varieties of the English language native to the United States ** Native Americans in the United States, indigenous peoples of the United States * American, something of, from, or related to the Americas, also known as "America" ** Indigenous peoples of the Americas * American (word), for analysis and history of the meanings in various contexts Organizations * American Airlines, U.S.-based airline headquartered in Fort Worth, Texas * American Athletic Conference, an American college athletic conference * American Recordings (record label), a record label previously known as Def American * American University, in Washington, D.C. Sports teams Soccer * Ba ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1996 Deaths
File:1996 Events Collage.png, From left, clockwise: A bomb explodes at Centennial Olympic Park in Atlanta, set off by a radical anti-abortionist; The center fuel tank explodes on TWA Flight 800, causing the plane to crash and killing everyone on board; Eight people die in a blizzard on Mount Everest; Dolly the Sheep becomes the first mammal to have been cloned from an adult somatic cell; The Port Arthur Massacre occurs on Tasmania, and leads to major changes in Australia's gun laws; Macarena, sung by Los del Río and remixed by The Bayside Boys, becomes a major dance craze and cultural phenomenon; Ethiopian Airlines Flight 961 crash-ditches off of the Comoros Islands after the plane was hijacked; the 1996 Summer Olympics are held in Atlanta, marking the Centennial (100th Anniversary) of the modern Olympic Games., 300x300px, thumb rect 0 0 200 200 Centennial Olympic Park bombing rect 200 0 400 200 TWA FLight 800 rect 400 0 600 200 1996 Mount Everest disaster rect 0 200 30 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1910 Births
Year 191 ( CXCI) was a common year starting on Friday (link will display the full calendar) of the Julian calendar. At the time, it was known as the Year of the Consulship of Apronianus and Bradua (or, less frequently, year 944 ''Ab urbe condita''). The denomination 191 for this year has been used since the early medieval period, when the Anno Domini calendar era became the prevalent method in Europe for naming years. Events By place Parthia * King Vologases IV of Parthia dies after a 44-year reign, and is succeeded by his son Vologases V. China * A coalition of Chinese warlords from the east of Hangu Pass launches a punitive campaign against the warlord Dong Zhuo, who seized control of the central government in 189, and held the figurehead Emperor Xian hostage. After suffering some defeats against the coalition forces, Dong Zhuo forcefully relocates the imperial capital from Luoyang to Chang'an. Before leaving, Dong Zhuo orders his troops to loot the tombs of the Ha ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
William Woods University
William Woods University is a private university in Fulton, Missouri. Founded in 1870, the university is accredited by the Higher Learning Commission. Expanding its mission to address the need for graduate and adult-oriented programs, the institution became known as William Woods University in 1993. It began offering graduate degrees and admitting men as well as women into all of its programs. It enrolled 1,681 students in 2021. History First known as the Female Orphan School, the institution was founded in 1870 in Camden Point, Missouri in response to the needs of girls who were orphaned during the American Civil War. During the late nineteenth century, the institution moved to Fulton and expanded its elementary and secondary programs to accommodate young women who aspired to become teachers. Known briefly at the beginning of the twentieth century as Daughters College, it changed its name to William Woods College in 1900 to honor a major benefactor (William S. Woods, presiden ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Glutathione Synthetase Deficiency
Glutathione synthetase deficiency (GSD) is a rare autosomal recessive metabolic disorder that prevents the production of glutathione. Glutathione helps prevent damage to cells by neutralizing harmful molecules generated during energy production. Glutathione also plays a role in processing medications and cancer-causing compounds (carcinogens), and building DNA, proteins, and other important cellular components. Genetics Mutations in the ''GSS'' gene cause glutathione synthetase deficiency. This gene provides instructions for making the enzyme glutathione synthetase. This enzyme is involved in a process called the gamma-glutamyl cycle, which takes place in most of the body's cells. This cycle is necessary for producing a molecule called glutathione. Glutathione protects cells from damage caused by unstable oxygen-containing molecules, which are byproducts of energy production. Glutathione is called an antioxidant because of its role in protecting cells from the damaging effects ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chelation
Chelation is a type of bonding of ions and molecules to metal ions. It involves the formation or presence of two or more separate coordinate bonds between a Denticity, polydentate (multiple bonded) ligand and a single central metal atom. These ligands are called chelants, chelators, chelating agents, or sequestering agents. They are usually organic compounds, but this is not a necessity, as in the case of zinc and its use as a maintenance therapy to prevent the absorption of copper in people with Wilson's disease. Chelation is useful in applications such as providing nutritional supplements, in chelation therapy to remove toxic metals from the body, as contrast medium, contrast agents in MRI, MRI scanning, in manufacturing using homogeneous catalysts, in chemical water treatment to assist in the removal of metals, and in fertilizers. Chelate effect The chelate effect is the greater affinity of chelating ligands for a metal ion than that of similar nonchelating (monodentate ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hemoglobin
Hemoglobin (haemoglobin BrE) (from the Greek word αἷμα, ''haîma'' 'blood' + Latin ''globus'' 'ball, sphere' + ''-in'') (), abbreviated Hb or Hgb, is the iron-containing oxygen-transport metalloprotein present in red blood cells (erythrocytes) of almost all vertebrates (the exception being the fish family Channichthyidae) as well as the tissues of some invertebrates. Hemoglobin in blood carries oxygen from the respiratory organs (''e.g.'' lungs or gills) to the rest of the body (''i.e.'' tissues). There it releases the oxygen to permit aerobic respiration to provide energy to power functions of an organism in the process called metabolism. A healthy individual human has 12to 20grams of hemoglobin in every 100mL of blood. In mammals, the chromoprotein makes up about 96% of the red blood cells' dry content (by weight), and around 35% of the total content (including water). Hemoglobin has an oxygen-binding capacity of 1.34mL O2 per gram, which increases the total blood oxygen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Immune Thrombocytopenic Purpura
Immune thrombocytopenic purpura (ITP), also known as idiopathic thrombocytopenic purpura or immune thrombocytopenia, is a type of thrombocytopenic purpura defined as an isolated low platelet count with a normal bone marrow in the absence of other causes of low platelets. It causes a characteristic red or purple bruise-like rash and an increased tendency to bleed. Two distinct clinical syndromes manifest as an acute condition in children and a chronic condition in adults. The acute form often follows an infection and spontaneously resolves within two months. Chronic immune thrombocytopenia persists longer than six months with a specific cause being unknown. ITP is an autoimmune disease with antibodies detectable against several platelet surface structures. ITP is diagnosed by identifying a low platelet count on a complete blood count (a common blood test). However, since the diagnosis depends on the exclusion of other causes of a low platelet count, additional investigations (su ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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