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Viridiflorol
Viridiflorol is a chemical compound, classified as a sesquiterpenoid, that has been isolated from the essential oils of a variety of plants including ''Melaleuca quinquenervia'' (broad-leaved paperbark), ''Melaleuca alternifolia'' (tea tree), and ''Allophylus edulis''. Viridiflorol has shown moderate antibacterial activity against ''Mycobacterium tuberculosis'', the causative agent of tuberculosis, in an ''in vitro ''In vitro'' (meaning in glass, or ''in the glass'') studies are performed with microorganisms, cells, or biological molecules outside their normal biological context. Colloquially called "test-tube experiments", these studies in biology an ...'' assay. It is also produced by the endophytic root fungus ''Serendipita indica'' and exhibits antifungal activity against ''Colletotrichum truncatum'' References {{reflist Tertiary alcohols ...
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Allophylus Edulis
''Allophylus edulis'' ( pt, chal-chal) is a plant species in the genus ''Allophylus'' endemic to the Guianas, Brazil, Bolivia, Paraguay, Argentina and Uruguay. Phytochemistry Quebrachitol, a cyclitol, and viridiflorol, a sesquiterpenoid Sesquiterpenes are a class of terpenes that consist of three isoprene units and often have the molecular formula C15H24. Like monoterpenes, sesquiterpenes may be cyclic or contain rings, including many unique combinations. Biochemical modificati ..., are found in ''A. edulis''. Vernacular names This plant has several different common names. In Paraguay it's called ''kokû'', with a nasal ending. In Argentina, the common name is ''chal-chal'' (hence Los Chalchaleros, a folkloric music group), as in Portuguese. Other names in Brazil are ''aperta-goela, baga-de-morcego, chala-chala, chale-chale, cocum, fruta-de-paraó, fruta-de-passarinho, fruta-de-pavão, fruta-de-pavó, fruta-de-pombo, murta-branca, murta-vermelha, olho-de-pombo, pé-de-ga ...
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Essential Oil
An essential oil is a concentrated hydrophobic liquid containing volatile (easily evaporated at normal temperatures) chemical compounds from plants. Essential oils are also known as volatile oils, ethereal oils, aetheroleum, or simply as the oil of the plant from which they were extracted, such as oil of clove. An essential oil is essential in the sense that it contains the essence of the plant's fragrance—the characteristic fragrance of the plant from which it is derived. The term "essential" used here does ''not'' mean indispensable or usable by the human body, as with the terms essential amino acid or essential fatty acid, which are so called because they are nutritionally required by a living organism. Essential oils are generally extracted by distillation, often by using steam. Other processes include expression, solvent extraction, '' sfumatura'', absolute oil extraction, resin tapping, wax embedding, and cold pressing. They are used in perfumes, cosmetics, soaps, air ...
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Melaleuca Quinquenervia
''Melaleuca quinquenervia'', commonly known as the broad-leaved paperbark, paper bark tea tree, punk tree or niaouli, is a small- to medium-sized tree of the myrtle family, Myrtaceae. It grows as a spreading tree up to tall, with its trunk covered by a white, beige and grey thick papery bark. The grey-green leaves are egg-shaped, and cream or white bottlebrush-like flowers appear from late spring to autumn. It was first formally described in 1797 by the Spanish naturalist Antonio José Cavanilles. Native to New Caledonia, Papua New Guinea and coastal eastern Australia, from Botany Bay in New South Wales northwards into Queensland, ''M. quinquenervia'' grows in swamps, on floodplains and near rivers and estuaries, often on silty soil. It has become naturalised in the Everglades in Florida, where it is considered a serious weed by the USDA. Description ''Melaleuca quinquenervia'' is a small to medium sized, spreading tree which usually grows to a height of high and a spread of ...
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Chemical Compound
A chemical compound is a chemical substance composed of many identical molecules (or molecular entities) containing atoms from more than one chemical element held together by chemical bonds. A molecule consisting of atoms of only one element is therefore not a compound. A compound can be transformed into a different substance by a chemical reaction, which may involve interactions with other substances. In this process, bonds between atoms may be broken and/or new bonds formed. There are four major types of compounds, distinguished by how the constituent atoms are bonded together. Molecular compounds are held together by covalent bonds; ionic compounds are held together by ionic bonds; intermetallic compounds are held together by metallic bonds; coordination complexes are held together by coordinate covalent bonds. Non-stoichiometric compounds form a disputed marginal case. A chemical formula specifies the number of atoms of each element in a compound molecule, using the s ...
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Sesquiterpenoid
Sesquiterpenes are a class of terpenes that consist of three isoprene units and often have the molecular formula C15H24. Like monoterpenes, sesquiterpenes may be cyclic or contain rings, including many unique combinations. Biochemical modifications such as oxidation or rearrangement produce the related sesquiterpenoids. Sesquiterpenes are found naturally in plants and insects, as semiochemicals, e.g. defensive agents or pheromones. Biosynthesis and examples The reaction of geranyl pyrophosphate with isopentenyl pyrophosphate results in the 15-carbon farnesyl pyrophosphate (FPP), which is an intermediate in the biosynthesis of sesquiterpenes such as farnesene. Cyclic sesquiterpenes are more common than cyclic monoterpenes because of the increased chain length and additional double bond in the sesquiterpene precursors. In addition to common six-membered ring systems such as the ones found in zingiberene and bisacurone, cyclization of one end of the chain to the other end can ...
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Melaleuca Alternifolia
''Melaleuca alternifolia'', commonly known as tea tree, is a species of tree or tall shrub in the myrtle family, Myrtaceae. Endemic to Australia, it occurs in southeast Queensland and the north coast and adjacent ranges of New South Wales where it grows along streams and on swampy flats, and is often the dominant species where it occurs. Description ''Melaleuca alternifolia'' is a small tree that can grow to about with a bushy crown and whitish, papery bark. The leaves are arranged alternately, sometimes scattered or whorled. The leaves are smooth, soft, linear in shape, long and wide. They are also rich in oil with the glands prominent. Flowers occur in white or cream-colored masses of spikes long over a short period, mostly spring to early summer, and give the tree an appearance of looking fluffy. The small woody, cup-shaped fruit, in diameter are scattered along the branches. Taxonomy and naming This species was first formally described in 1905 by Joseph Maiden and ...
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Mycobacterium Tuberculosis
''Mycobacterium tuberculosis'' (M. tb) is a species of pathogenic bacteria in the family Mycobacteriaceae and the causative agent of tuberculosis. First discovered in 1882 by Robert Koch, ''M. tuberculosis'' has an unusual, waxy coating on its cell surface primarily due to the presence of mycolic acid. This coating makes the cells impervious to Gram staining, and as a result, ''M. tuberculosis'' can appear weakly Gram-positive. Acid-fastness, Acid-fast stains such as Ziehl–Neelsen stain, Ziehl–Neelsen, or Fluorescence, fluorescent stains such as Auramine O, auramine are used instead to identify ''M. tuberculosis'' with a microscope. The physiology of ''M. tuberculosis'' is highly aerobic organism, aerobic and requires high levels of oxygen. Primarily a pathogen of the mammalian respiratory system, it infects the lungs. The most frequently used diagnostic methods for tuberculosis are the Mantoux test, tuberculin skin test, Acid-Fast Stain, acid-fast stain, Microbiological cultu ...
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Tuberculosis
Tuberculosis (TB) is an infectious disease usually caused by '' Mycobacterium tuberculosis'' (MTB) bacteria. Tuberculosis generally affects the lungs, but it can also affect other parts of the body. Most infections show no symptoms, in which case it is known as latent tuberculosis. Around 10% of latent infections progress to active disease which, if left untreated, kill about half of those affected. Typical symptoms of active TB are chronic cough with blood-containing mucus, fever, night sweats, and weight loss. It was historically referred to as consumption due to the weight loss associated with the disease. Infection of other organs can cause a wide range of symptoms. Tuberculosis is spread from one person to the next through the air when people who have active TB in their lungs cough, spit, speak, or sneeze. People with Latent TB do not spread the disease. Active infection occurs more often in people with HIV/AIDS and in those who smoke. Diagnosis of active TB is ...
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In Vitro
''In vitro'' (meaning in glass, or ''in the glass'') studies are performed with microorganisms, cells, or biological molecules outside their normal biological context. Colloquially called "test-tube experiments", these studies in biology and its subdisciplines are traditionally done in labware such as test tubes, flasks, Petri dishes, and microtiter plates. Studies conducted using components of an organism that have been isolated from their usual biological surroundings permit a more detailed or more convenient analysis than can be done with whole organisms; however, results obtained from ''in vitro'' experiments may not fully or accurately predict the effects on a whole organism. In contrast to ''in vitro'' experiments, ''in vivo'' studies are those conducted in living organisms, including humans, and whole plants. Definition ''In vitro'' ( la, in glass; often not italicized in English usage) studies are conducted using components of an organism that have been isolated fro ...
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