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Vesicular Transport Adaptor Protein
Vesicular transport adaptor proteins are proteins involved in forming complexes that function in the trafficking of molecules from one subcellular location to another. These complexes concentrate the correct cargo molecules in vesicles that bud or extrude off of one organelle and travel to another location, where the cargo is delivered. While some of the details of how these adaptor proteins achieve their trafficking specificity has been worked out, there is still much to be learned. There are several human disorders associated with defects in components of these complexes including Alzheimer's and Parkinson's diseases. The proteins Most of the adaptor proteins are heterotetramers. In the AP complexes, there are two large proteins ( ∼100 k D) and two smaller proteins. One of the large proteins is termed β (beta), with β1 in the AP-1 complex, β2 in the AP-2 complex, and so on. The other large protein has different designations in the different complexes. In AP-1 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Approximation
An approximation is anything that is intentionally similar but not exactly equality (mathematics), equal to something else. Etymology and usage The word ''approximation'' is derived from Latin ''approximatus'', from ''proximus'' meaning ''very near'' and the prefix ''ad-'' (''ad-'' before ''p'' becomes ap- by assimilation (phonology), assimilation) meaning ''to''. Words like ''approximate'', ''approximately'' and ''approximation'' are used especially in technical or scientific contexts. In everyday English, words such as ''roughly'' or ''around'' are used with a similar meaning. It is often found abbreviated as ''approx.'' The term can be applied to various properties (e.g., value, quantity, image, description) that are nearly, but not exactly correct; similar, but not exactly the same (e.g., the approximate time was 10 o'clock). Although approximation is most often applied to numbers, it is also frequently applied to such things as Function (mathematics), mathematical functio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Coatomer
The coatomer is a protein complex that coats membrane-bound transport vesicles. Two types of coatomers are known: *COPI (retrograde transport from trans-Golgi network to cis-Golgi network and endoplasmic reticulum) *COPII (anterograde transport from ER to the cis-Golgi) Coatomers are functionally analogous and evolutionarily homologous to clathrin adaptor proteins, also known as adaptins, which regulate endocytosis from the plasma membrane and transport from the trans-Golgi network to lysosomes. Structure The coatomer protein complex is made up of seven nonidentical protein subunits. These seven nonidentical protein subunits are part of two protein subcomplexes. The first subcomplex consists of Ret1(α-COP), Sec27(β’-COP), and Sec 28(ε-COP). The second subcomplex consists of Sec26 (β-COP), Sec21 (γ-COP), Ret2(δ-COP), and Ret3 (ζ-COP). COP I COPI is a coatomer that coats the vesicles transporting proteins from the Golgi complex to the ER. This pathway is referred to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
COPI
COPI is a coatomer, a protein complex that coats vesicles transporting proteins from the ''cis'' end of the Golgi complex The Golgi apparatus (), also known as the Golgi complex, Golgi body, or simply the Golgi, is an organelle found in most eukaryotic cells. Part of the endomembrane system in the cytoplasm, it packages proteins into membrane-bound vesicles insi ... back to the rough endoplasmic reticulum (ER), where they were originally Translation (genetics), synthesized, and between Golgi compartments. This type of transport is ''retrograde transport'', in contrast to the ''anterograde transport'' associated with the COPII protein. The name "COPI" refers to the specific coat protein complex that initiates the budding process on the ''cis''-Golgi membrane. The coat consists of large protein subcomplexes that are made of seven different protein subunits, namely α, β, β', γ, Archain, δ, ε and COPZ1, ζ. Coat proteins Coat protein, or COPI, is an ADP ribosylation ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sigma
Sigma (; uppercase Σ, lowercase σ, lowercase in word-final position ς; grc-gre, σίγμα) is the eighteenth letter of the Greek alphabet. In the system of Greek numerals, it has a value of 200. In general mathematics, uppercase Σ is used as an operator for summation. When used at the end of a letter-case word (one that does not use all caps), the final form (ς) is used. In ' (Odysseus), for example, the two lowercase sigmas (σ) in the center of the name are distinct from the word-final sigma (ς) at the end. The Latin letter S derives from sigma while the Cyrillic letter Es derives from a lunate form of this letter. History The shape (Σς) and alphabetic position of sigma is derived from the Phoenician letter ( ''shin''). Sigma's original name may have been ''san'', but due to the complicated early history of the Greek epichoric alphabets, ''san'' came to be identified as a separate letter in the Greek alphabet, represented as Ϻ. Herodotus reports that "san" wa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mu (letter)
Mu (uppercase Μ, lowercase μ; Ancient Greek , ell, μι or μυ—both ) is the 12th letter of the Greek alphabet, representing the voiced bilabial nasal . In the system of Greek numerals it has a value of 40. Mu was derived from the Egyptian hieroglyphic symbol for water, which had been simplified by the Phoenicians and named after their word for water, to become 𐤌 (mem). Letters that derive from mu include the Roman M and the Cyrillic М. Names Ancient Greek In Ancient Greek, the name of the letter was written and pronounced Modern Greek In Modern Greek, the letter is spelled and pronounced . In polytonic orthography, it is written with an acute accent: . Use as symbol The lowercase letter mu (μ) is used as a special symbol in many academic fields. Uppercase mu is not used, because it appears identical to Latin M. Measurement *the SI prefix ''micro-'', which represents one millionth, or 10−6. Lowercase letter "u" is often substituted for "μ" w ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Zeta
Zeta (, ; uppercase Ζ, lowercase ζ; grc, ζῆτα, el, ζήτα, label= Demotic Greek, classical or ''zē̂ta''; ''zíta'') is the sixth letter of the Greek alphabet. In the system of Greek numerals, it has a value of 7. It was derived from the Phoenician letter zayin . Letters that arose from zeta include the Roman Z and Cyrillic З. Name Unlike the other Greek letters, this letter did not take its name from the Phoenician letter from which it was derived; it was given a new name on the pattern of beta, eta and theta. The word ''zeta'' is the ancestor of ''zed'', the name of the Latin letter Z in Commonwealth English. Swedish and many Romanic languages (such as Italian and Spanish) do not distinguish between the Greek and Roman forms of the letter; "''zeta''" is used to refer to the Roman letter Z as well as the Greek letter. Uses Letter The letter ζ represents the voiced alveolar fricative in Modern Greek Modern Greek (, , or , ''Kiní Neoellinikí Gl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Epsilon
Epsilon (, ; uppercase , lowercase or lunate ; el, έψιλον) is the fifth letter of the Greek alphabet, corresponding phonetically to a mid front unrounded vowel or . In the system of Greek numerals it also has the value five. It was derived from the Phoenician letter He . Letters that arose from epsilon include the Roman E, Ë and Ɛ, and Cyrillic Е, È, Ё, Є and Э. The name of the letter was originally (), but it was later changed to ( 'simple e') in the Middle Ages to distinguish the letter from the digraph , a former diphthong that had come to be pronounced the same as epsilon. The uppercase form of epsilon is identical to Latin E but has its own code point in Unicode: . The lowercase version has two typographical variants, both inherited from medieval Greek handwriting. One, the most common in modern typography and inherited from medieval minuscule, looks like a reversed number "3" and is encoded . The other, also known as lunate or uncial epsilon ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Delta (letter)
Delta (; uppercase Δ, lowercase δ or 𝛿; el, δέλτα, ''délta'', ) is the fourth letter of the Greek alphabet. In the system of Greek numerals it has a value of 4. It was derived from the Phoenician letter dalet 𐤃. Letters that come from delta include Latin D and Cyrillic Д. A river delta (originally, the delta of the Nile River) is so named because its shape approximates the triangular uppercase letter delta. Contrary to a popular legend, this use of the word ''delta'' was not coined by Herodotus. Pronunciation In Ancient Greek, delta represented a voiced dental plosive . In Modern Greek, it represents a voiced dental fricative , like the "th" in "that" or "this" (while in foreign words is instead commonly transcribed as ντ). Delta is romanized as ''d'' or ''dh''. Uppercase The uppercase letter Δ is used to denote: * Change of any changeable quantity, in mathematics and the sciences (more specifically, the difference operator); for example, in:\frac = \f ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alpha
Alpha (uppercase , lowercase ; grc, ἄλφα, ''álpha'', or ell, άλφα, álfa) is the first letter of the Greek alphabet. In the system of Greek numerals, it has a value of one. Alpha is derived from the Phoenician letter aleph , which is the West Semitic word for " ox". Letters that arose from alpha include the Latin letter A and the Cyrillic letter А. Uses Greek In Ancient Greek, alpha was pronounced and could be either phonemically long ( ː or short ( . Where there is ambiguity, long and short alpha are sometimes written with a macron and breve today: Ᾱᾱ, Ᾰᾰ. * ὥρα = ὥρᾱ ''hōrā'' "a time" * γλῶσσα = γλῶσσᾰ ''glôssa'' "tongue" In Modern Greek, vowel length has been lost, and all instances of alpha simply represent the open front unrounded vowel . In the polytonic orthography of Greek, alpha, like other vowel letters, can occur with several diacritic marks: any of three accent symbols (), and either of two breathing mark ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gamma
Gamma (uppercase , lowercase ; ''gámma'') is the third letter of the Greek alphabet. In the system of Greek numerals it has a value of 3. In Ancient Greek, the letter gamma represented a voiced velar stop . In Modern Greek, this letter represents either a voiced velar fricative or a voiced palatal fricative (while /g/ in foreign words is instead commonly transcribed as γκ). In the International Phonetic Alphabet and other modern Latin-alphabet based phonetic notations, it represents the voiced velar fricative. History The Greek letter Gamma Γ is a grapheme derived from the Phoenician letter (''gīml'') which was rotated from the right-to-left script of Canaanite to accommodate the Greek language's writing system of left-to-right. The Canaanite grapheme represented the /g/ phoneme in the Canaanite language, and as such is cognate with ''gimel'' ג of the Hebrew alphabet. Based on its name, the letter has been interpreted as an abstract representation of a camel's ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
AP2 Adaptor Complex
The AP2 adaptor complex is a multimeric protein that works on the cell membrane to internalize cargo in clathrin-mediated endocytosis. It is a stable complex of four adaptins which give rise to a structure that has a core domain and two appendage domains attached to the core domain by polypeptide linkers. These appendage domains are sometimes called 'ears'. The core domain binds to the membrane and to cargo destined for internalisation. The alpha and beta appendage domains bind to accessory proteins and to clathrin. Their interactions allow the temporal and spatial regulation of the assembly of clathrin-coated vesicles and their endocytosis. The AP-2 complex is a heterotetramer consisting of two large adaptins (α and β), a medium adaptin (μ), and a small adaptin (σ): * complex 2 ** AP2A1 (α unit 1) ** AP2A2 (α unit 2) ** AP2B1 (β unit) ** AP2M1 (μ unit) ** AP2S1 (σ unit) Structure The AP2 adaptor complex exists in two primary conformations: the open conformation (active ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
