VUF-8430

	VUF-8430 VUF-8430 is a histamine agonist A histamine agonist is a drug which causes increased activity at one or more of the four histamine receptor subtypes. H2: Betazole and Impromidine are examples of agonists used in diagnostics to increase histamine. H3: Betahistine is a weak Hi ... selective for the H4 subtype. References Histamine agonists Guanidines Thioureas {{Pharma-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Histamine H4 Receptor The histamine H4 receptor, like the other three histamine receptors, is a member of the G protein-coupled receptor superfamily that in humans is encoded by the ''HRH4'' gene. Discovery Unlike the histamine receptors discovered earlier, H4 was found in 2000 through a search of the human genomic DNA data base. Tissue distribution H4 is highly expressed in bone marrow and white blood cells and regulates neutrophil release from bone marrow and subsequent infiltration in the zymosan-induced pleurisy mouse model. It was also found that H4R exhibits a uniform expression pattern in the human oral epithelium. Function The Histamine H4 receptor has been shown to be involved in mediating eosinophil shape change and mast cell chemotaxis. This occurs via the βγ subunit acting at phospholipase C to cause actin polymerization and eventually chemotaxis. Structure The 3D structure of the H4 receptor has not been solved yet due to the difficulties of GPCR crystallization. Some attempts have ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Histamine Agonist A histamine agonist is a drug which causes increased activity at one or more of the four histamine receptor subtypes. H2: Betazole and Impromidine are examples of agonists used in diagnostics to increase histamine. H3: Betahistine is a weak Histamine1 agonist and a very strong Histamine3 antagonist (paradoxically histamine increasing). See also * Histamine antagonist Antihistamines are drugs which treat allergic rhinitis, common cold, influenza, and other allergies. Typically, people take antihistamines as an inexpensive, generic (not patented) drug that can be bought without a prescription and provides re ... External links * * {{pharmacology-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Histamine Agonists A histamine agonist is a drug which causes increased activity at one or more of the four histamine receptor subtypes. H2: Betazole and Impromidine are examples of agonists used in diagnostics to increase histamine. H3: Betahistine is a weak Histamine1 agonist and a very strong Histamine3 antagonist (paradoxically histamine increasing). See also * Histamine antagonist Antihistamines are drugs which treat allergic rhinitis, common cold, influenza, and other allergies. Typically, people take antihistamines as an inexpensive, generic (not patented) drug that can be bought without a prescription and provides re ... External links * * {{pharmacology-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Guanidines Guanidine is the compound with the formula HNC(NH2)2. It is a colourless solid that dissolves in polar solvents. It is a strong base that is used in the production of plastics and explosives. It is found in urine predominantly in patients experiencing renal failure. A guanidine moiety also appears in larger organic molecules, including on the side chain of arginine. Structure Guanidine can be thought of as a nitrogenous analogue of carbonic acid. That is, the C=O group in carbonic acid is replaced by a C=NH group, and each OH is replaced by a group. Isobutene can be seen as the carbon analogue in much the same way. A detailed crystallographic analysis of guanidine was elucidated 148 years after its first synthesis, despite the simplicity of the molecule. In 2013, the positions of the hydrogen atoms and their displacement parameters were accurately determined using single-crystal neutron diffraction. Production Guanidine can be obtained from natural sources, being first isolat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]