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VR-RNA
In molecular biology, VR-RNA is a small RNA produced by ''Clostridium perfringens''. It functions as a regulator of the two-component VirR/VirS system. VR-RNA regulates numerous genes including: *Toxin-encoding genes plc, colA and cpb2 *Other virulence-related genes such as hyaluronidases and sialidase *Possible collagen adhesin gene () *Extracellular nuclease, cadA *Enzymes such as Acid phosphatase, Heme oxygenase HemO and N-acetylglucosaminidases *Genes encoding transport proteins *Genes involved in carbohydrate metabolism *Genes encoding transport proteins *Arginine deiminase (ADI) pathway genes *Genes involved in citrate metabolism VR-RNA regulates the toxin colA (collagenase) by base-pairing to colA mRNA, the 3′ end of VR-RNA base-pairs to a region in the 5′UTR of the colA mRNA. This induces cleavage of the colA mRNA in the 5′ UTR and leads to stabilisation of the mRNA and increased translation. See also *Bacterial small RNA Bacterial small RNAs (bsRNA) are small RN ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bacterial Small RNA
Bacterial small RNAs (bsRNA) are small RNAs produced by bacteria; they are 50- to 500-nucleotide non-coding RNA molecules, highly structured and containing several stem-loops. Numerous sRNAs have been identified using both computational analysis and laboratory-based techniques such as Northern blotting, microarrays and RNA-Seq in a number of bacterial species including ''Escherichia coli'', the model pathogen ''Salmonella'', the nitrogen-fixing alphaproteobacterium '' Sinorhizobium meliloti'', marine cyanobacteria, '' Francisella tularensis'' (the causative agent of tularaemia), ''Streptococcus pyogenes','' the pathogen ''Staphylococcus aureus'''','' and the plant pathogen '' Xanthomonas oryzae pathovar oryzae''. Bacterial sRNAs affect how genes are expressed within bacterial cells via interaction with mRNA or protein, and thus can affect a variety of bacterial functions like metabolism, virulence, environmental stress response, and structure. Origin In the 1960s, the abbreviatio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
