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Up-and-Down Designs
Up-and-down designs (UDDs) are a family of statistical experiment designs used in dose-finding experiments in science, engineering, and medical research. Dose-finding experiments have ''binary responses'': each individual outcome can be described as one of two possible values, such as success vs. failure or toxic vs. non-toxic. Mathematically the binary responses are coded as 1 and 0. The goal of dose-finding experiments is to estimate the strength of treatment (i.e., the "dose") that would trigger the "1" response a pre-specified proportion of the time. This dose can be envisioned as a percentile of the distribution of response thresholds. An example where dose-finding is used is in an experiment to estimate the LD50 of some toxic chemical with respect to mice. Dose-finding designs are sequential and response-adaptive: the dose at a given point in the experiment depends upon previous outcomes, rather than be fixed ''a priori''. Dose-finding designs are generally more efficient ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Statistical
Statistics (from German: ''Statistik'', "description of a state, a country") is the discipline that concerns the collection, organization, analysis, interpretation, and presentation of data. In applying statistics to a scientific, industrial, or social problem, it is conventional to begin with a statistical population or a statistical model to be studied. Populations can be diverse groups of people or objects such as "all people living in a country" or "every atom composing a crystal". Statistics deals with every aspect of data, including the planning of data collection in terms of the design of surveys and experiments.Dodge, Y. (2006) ''The Oxford Dictionary of Statistical Terms'', Oxford University Press. When census data cannot be collected, statisticians collect data by developing specific experiment designs and survey samples. Representative sampling assures that inferences and conclusions can reasonably extend from the sample to the population as a whole. An experim ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Density Function
In probability theory, a probability density function (PDF), or density of a continuous random variable, is a function whose value at any given sample (or point) in the sample space (the set of possible values taken by the random variable) can be interpreted as providing a ''relative likelihood'' that the value of the random variable would be close to that sample. Probability density is the probability per unit length, in other words, while the ''absolute likelihood'' for a continuous random variable to take on any particular value is 0 (since there is an infinite set of possible values to begin with), the value of the PDF at two different samples can be used to infer, in any particular draw of the random variable, how much more likely it is that the random variable would be close to one sample compared to the other sample. In a more precise sense, the PDF is used to specify the probability of the random variable falling ''within a particular range of values'', as opposed to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Isotonic Regression
In statistics and numerical analysis, isotonic regression or monotonic regression is the technique of fitting a free-form line to a sequence of observations such that the fitted line is non-decreasing (or non-increasing) everywhere, and lies as close to the observations as possible. Applications Isotonic regression has applications in statistical inference. For example, one might use it to fit an isotonic curve to the means of some set of experimental results when an increase in those means according to some particular ordering is expected. A benefit of isotonic regression is that it is not constrained by any functional form, such as the linearity imposed by linear regression, as long as the function is monotonic increasing. Another application is nonmetric multidimensional scaling, where a low-dimensional embedding for data points is sought such that order of distances between points in the embedding matches order of dissimilarity between points. Isotonic regression is use ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Probit Model
In statistics, a probit model is a type of regression where the dependent variable can take only two values, for example married or not married. The word is a portmanteau, coming from ''probability'' + ''unit''. The purpose of the model is to estimate the probability that an observation with particular characteristics will fall into a specific one of the categories; moreover, classifying observations based on their predicted probabilities is a type of binary classification model. A probit model is a popular specification for a binary response model. As such it treats the same set of problems as does logistic regression using similar techniques. When viewed in the generalized linear model framework, the probit model employs a probit link function. It is most often estimated using the maximum likelihood procedure, such an estimation being called a probit regression. Conceptual framework Suppose a response variable ''Y'' is ''binary'', that is it can have only two possible outcomes ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Abscissa
In common usage, the abscissa refers to the (''x'') coordinate and the ordinate refers to the (''y'') coordinate of a standard two-dimensional graph. The distance of a point from the y-axis, scaled with the x-axis, is called abscissa or x coordinate of the point. The distance of a point from x-axis scaled with the y-axis is called ordinate. For example, if (x, y) is an ordered pair in the Cartesian plane, then the first coordinate in the plane (x) is called the abscissa and the second coordinate (y) is the ordinate. In mathematics, the abscissa (; plural ''abscissae'' or ''abscissas'') and the ordinate are respectively the first and second coordinate of a point in a Cartesian coordinate system: :abscissa \equiv x-axis (horizontal) coordinate :ordinate \equiv y-axis (vertical) coordinate Usually these are the horizontal and vertical coordinates of a point in plane, the rectangular coordinate system. An ordered pair consists of two terms—the abscissa (horizontal, usually '' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Misrak Gezmu
Misrak Gezmu is an Ethiopian-American statistician who works as a mathematical statistician and grant officer for the Biostatistics Research Branch of the National Institute of Allergy and Infectious Diseases. She is known for her pioneering doctoral research on the statistics of up-and-down designs. Gezmu is originally from Ethiopia. She earned a Ph.D. in statistics from American University in Washington, D.C. in 1996; Her doctoral dissertation, ''The Geometric Up-and-Down Design for Allocating Dosage Levels'', was supervised by Nancy Flournoy. While still a doctoral student, she became an assistant professor of decision sciences at Norfolk State University in Virginia in 1993. She moved to the National Institute of Allergy and Infectious Diseases in 1998. Gezmu is a Fellow of the American Statistical Association Like many other academic professional societies, the American Statistical Association (ASA) uses the title of Fellow of the American Statistical Association as its h ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Newton–Raphson
In numerical analysis, Newton's method, also known as the Newton–Raphson method, named after Isaac Newton and Joseph Raphson, is a root-finding algorithm which produces successively better approximations to the roots (or zeroes) of a real-valued function. The most basic version starts with a single-variable function defined for a real variable , the function's derivative , and an initial guess for a root of . If the function satisfies sufficient assumptions and the initial guess is close, then :x_ = x_0 - \frac is a better approximation of the root than . Geometrically, is the intersection of the -axis and the tangent of the graph of at : that is, the improved guess is the unique root of the linear approximation at the initial point. The process is repeated as :x_ = x_n - \frac until a sufficiently precise value is reached. This algorithm is first in the class of Householder's methods, succeeded by Halley's method. The method can also be extended to complex functions an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mode (statistics)
The mode is the value that appears most often in a set of data values. If is a discrete random variable, the mode is the value (i.e, ) at which the probability mass function takes its maximum value. In other words, it is the value that is most likely to be sampled. Like the statistical mean and median, the mode is a way of expressing, in a (usually) single number, important information about a random variable or a population. The numerical value of the mode is the same as that of the mean and median in a normal distribution, and it may be very different in highly skewed distributions. The mode is not necessarily unique to a given discrete distribution, since the probability mass function may take the same maximum value at several points , , etc. The most extreme case occurs in uniform distributions, where all values occur equally frequently. When the probability density function of a continuous distribution has multiple local maxima it is common to refer to all of the local ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Asymptotic Distribution
In mathematics and statistics, an asymptotic distribution is a probability distribution that is in a sense the "limiting" distribution of a sequence of distributions. One of the main uses of the idea of an asymptotic distribution is in providing approximations to the cumulative distribution functions of statistical estimators. Definition A sequence of distributions corresponds to a sequence of random variables ''Zi'' for ''i'' = 1, 2, ..., I . In the simplest case, an asymptotic distribution exists if the probability distribution of ''Zi'' converges to a probability distribution (the asymptotic distribution) as ''i'' increases: see convergence in distribution. A special case of an asymptotic distribution is when the sequence of random variables is always zero or ''Zi'' = 0 as ''i'' approaches infinity. Here the asymptotic distribution is a degenerate distribution, corresponding to the value zero. However, the most usual sense in which the term asymptotic distribution is used ari ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
