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Ungeremine
Ungeremine is a betaine-type alkaloid isolated from ''Nerine bowdenii'' and related plants such as ''Pancratium maritimum''. Pharmacologically, it is of interest as an acetylcholinesterase inhibitor and accordingly as possibly relevant to Alzheimer's disease. It also has been investigated as a bactericide A bactericide or bacteriocide, sometimes abbreviated Bcidal, is a substance which kills bacteria. Bactericides are disinfectants, antiseptics, or antibiotics. However, material surfaces can also have bactericidal properties based solely on their .... References Acetylcholinesterase inhibitors Quinoline alkaloids Isoquinoline alkaloids Bactericides Phenols Benzodioxoles {{alkaloid-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nerine Bowdenii
''Nerine bowdenii'' is a species of flowering plant in the family (biology), family Amaryllidaceae. It is an herbaceous plant, herbaceous bulbous perennial plant, perennial, growing to tall by , with strap-shaped leaves and large umbels of lily-like pink flowers in late summer and autumn. The common names of the species are Cornish lily, Cape flower, Guernsey lily, and Bowden lily. However, it is neither a true lilium, lily nor from Cornwall or Guernsey, but native plant, originates from South Africa (Eastern Cape, KwaZulu Natal, Free State (province), Free State, Drakensberg Mountains). Confusingly the name “Guernsey lily” is also applied to a related species, ''Nerine sarniensis''. The species was named in 1904 after Athelstan Cornish-Bowden who had sent bulbs of the plant to England from South Africa. Description ''N. bowdenii'' bulbs are in circumference. The bulbs are "shaped like old-fashioned Chianti, Chianti bottles". The plant has eight or more faintly-scented bri ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Acetylcholinesterase Inhibitor
Acetylcholinesterase inhibitors (AChEIs) also often called cholinesterase inhibitors, inhibit the enzyme acetylcholinesterase from breaking down the neurotransmitter acetylcholine into choline and acetate, thereby increasing both the level and duration of action of acetylcholine in the central nervous system, autonomic ganglia and neuromuscular junctions, which are rich in acetylcholine receptors. Acetylcholinesterase inhibitors are one of two types of cholinesterase inhibitors; the other being butyryl-cholinesterase inhibitors. Acetylcholinesterase is the primary member of the cholinesterase enzyme family. Acetylcholinesterase inhibitors are classified as reversible, irreversible, or quasi-irreversible (also called pseudo-irreversible). Mechanism of action Organophosphates Organophosphates like TEPP and sarin inhibit cholinesterases, enzymes that hydrolyze the neurotransmitter acetylcholine. The active centre of cholinesterases feature two important sites, namely the a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Acetylcholinesterase Inhibitors
Acetylcholinesterase inhibitors (AChEIs) also often called cholinesterase inhibitors, inhibit the enzyme acetylcholinesterase from breaking down the neurotransmitter acetylcholine into choline and acetate, thereby increasing both the level and duration of action of acetylcholine in the central nervous system, autonomic ganglia and neuromuscular junctions, which are rich in acetylcholine receptors. Acetylcholinesterase inhibitors are one of two types of cholinesterase inhibitors; the other being butyryl-cholinesterase inhibitors. Acetylcholinesterase is the primary member of the cholinesterase enzyme family. Acetylcholinesterase inhibitors are classified as reversible, irreversible, or quasi-irreversible (also called pseudo-irreversible). Mechanism of action Organophosphates Organophosphates like TEPP and sarin inhibit cholinesterases, enzymes that hydrolyze the neurotransmitter acetylcholine. The active centre of cholinesterases feature two important sites, namely th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Betaine
A betaine () in chemistry is any neutral chemical compound with a positively charged cationic functional group, such as a quaternary ammonium or phosphonium cation (generally: onium ions) that bears no hydrogen atom and with a negatively charged functional group such as a carboxylate group that may not be adjacent to the cationic site. Historically, the term was reserved for trimethylglycine (TMG) which is involved in methylation reactions and detoxification of homocysteine. This is a modified amino acid consisting of glycine with three methyl groups serving as methyl donor for various metabolic pathways. The pronunciation of the compound reflects its origin and first isolation from sugar ''beets'' (''Beta vulgaris'' subsp. ''vulgaris''), and does not derive from the Greek letter beta (β). It is commonly pronounced ''beta-INE'' or ''BEE-tayn''. In biological systems, many naturally occurring betaines serve as organic osmolytes. These are substances synthesized or taken up fr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alkaloid
Alkaloids are a class of basic, naturally occurring organic compounds that contain at least one nitrogen atom. This group also includes some related compounds with neutral and even weakly acidic properties. Some synthetic compounds of similar structure may also be termed alkaloids. In addition to carbon, hydrogen and nitrogen, alkaloids may also contain oxygen, sulfur and, more rarely, other elements such as chlorine, bromine, and phosphorus.Chemical Encyclopedia: alkaloids xumuk.ru Alkaloids are produced by a large variety of organisms including , , Medicinal plant, plants, an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pancratium Maritimum
''Pancratium maritimum'', or sea daffodil, is a species of bulbous plant native to the Canary Islands and both sides of the Mediterranean region and Black Sea from Portugal, Morocco and the Balearic Islands east to Turkey, Syria, Israel and the Caucasus. In the parts of its range on the south Bulgarian and north Turkish and Georgian coasts of Black Sea. It is also naturalized in southern California, Bermuda and the Azores. ''Pancratium maritimum'' grows on beaches and coastal sand dunes, often with much of the leaves and scapes buried in the sand. Other vernacular names are sea lily, sand daffodil, sand lily and lily of St. Nicholas, (although it is not a true lily). The specific epithet ''maritimum'' means "of the sea". Description ''Pancratium maritimum'' is a bulbous perennial with a long neck and glaucous, broadly linear leaves, evergreen, but the leaves often die back during hot summers. Scape to . Flowers 3–15 in an umbel, up to long, white. Corona two-thirds as ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alzheimer's Disease
Alzheimer's disease (AD) is a neurodegeneration, neurodegenerative disease that usually starts slowly and progressively worsens. It is the cause of 60–70% of cases of dementia. The most common early symptom is difficulty in short-term memory, remembering recent events. As the disease advances, symptoms can include primary progressive aphasia, problems with language, Orientation (mental), disorientation (including easily getting lost), mood swings, loss of motivation, self-neglect, and challenging behaviour, behavioral issues. As a person's condition declines, they often withdraw from family and society. Gradually, bodily functions are lost, ultimately leading to death. Although the speed of progression can vary, the typical life expectancy following diagnosis is three to nine years. The cause of Alzheimer's disease is poorly understood. There are many environmental and genetic risk factors associated with its development. The strongest genetic risk factor is from an alle ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bactericide
A bactericide or bacteriocide, sometimes abbreviated Bcidal, is a substance which kills bacteria. Bactericides are disinfectants, antiseptics, or antibiotics. However, material surfaces can also have bactericidal properties based solely on their physical surface structure, as for example biomaterials like insect wings. Disinfectants The most used disinfectants are those applying *active chlorine (i.e., hypochlorites, chloramines, dichloroisocyanurate and trichloroisocyanurate, wet chlorine, chlorine dioxide, etc.), *active oxygen (peroxides, such as peracetic acid, potassium persulfate, sodium perborate, sodium percarbonate, and urea perhydrate), *iodine (povidone-iodine, Lugol's solution, iodine tincture, iodinated nonionic surfactants), *concentrated alcohols (mainly ethanol, 1-propanol, called also n-propanol and 2-propanol, called isopropanol and mixtures thereof; further, 2-phenoxyethanol and 1- and 2-phenoxypropanols are used), * phenolic substances (such as phenol ( ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Quinoline Alkaloids
Quinoline alkaloids are naturally occurring chemical compounds from the group of alkaloids, which are chemically derived from quinoline. Some quinoline alkaloids show antiseptic, convulsive or antineoplastic effects. Examples Alkaloids with a quinoline partial structure are widespread and are usually further subdivided according to their occurrence and biogenetic origin. Among the quinoline alkaloids are the cinchona alkaloids quinine and quinidine, which are important due to their therapeutic potential, furthermore cinchonine and cinchonidine, as well as some furoquinoline alkaloids and acridine alkaloids. Strychnine and brucine, alkaloids of the nux vomica, which have a hydrogenated quinoline system, are also counted among the quinoline alkaloids. Also nitramarine (1-(2-quinolinyl)-β-carboline) belongs to the quinoline alkaloids. File:Chinin.svg, Qinine File:Chinidin.svg, Qinidine File:Cinchonidin.svg, Cinchonidine File:Strychnine2.svg, Strychnine Occurrence The quin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Isoquinoline Alkaloids
Isoquinoline alkaloids are natural products of the group of alkaloids, which are chemically derived from isoquinoline. They form the largest group among the alkaloids. Isoquinoline alkaloids can be further classified based on their different chemical basic structures. The most common structural types are the benzylisoquinolines and the aporphines.Bettina Ruff: ''Chemische und biochemische Methoden zur stereoselektiven Synthese von komplexen Naturstoffen.'' Verlag Logos, Berlin 2012, , S. 8. () According to current knowledge, a total of about 2500 isoquinoline alkaloids are known nowadays, which are mainly formed by plants.Jennifer M. Finefield, David H. Sherman, Martin Kreitman, Robert M. Williams: ''Enantiomere Naturstoffe: Vorkommen und Biogenese.'' In: ''Angewandte Chemie.'' Wiley-VCH, Weinheim 2012, doi:10.1002/ange.201107204, S. 4905–4915. Known examples Morphin - Morphine.svg, Morphine Codein - Codeine.svg, Codeine Papaverin - Papaverine.svg, Papaverine Berbe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bactericides
A bactericide or bacteriocide, sometimes abbreviated Bcidal, is a substance which kills bacteria. Bactericides are disinfectants, antiseptics, or antibiotics. However, material surfaces can also have bactericidal properties based solely on their physical surface structure, as for example biomaterials like insect wings. Disinfectants The most used disinfectants are those applying *active chlorine (i.e., hypochlorites, chloramines, sodium dichloroisocyanurate, dichloroisocyanurate and trichloroisocyanurate, wet chlorine, chlorine dioxide, etc.), *active oxygen (peroxides, such as peracetic acid, potassium persulfate, sodium perborate, sodium percarbonate, and urea perhydrate), *iodine (povidone-iodine, Lugol's solution, iodine tincture, iodinated nonionic surfactants), *concentrated alcohols (mainly ethanol, 1-propanol, called also n-propanol and 2-propanol, called isopropanol and mixtures thereof; further, 2-phenoxyethanol and 1- and 2-phenoxypropanols are used), *phenols, phenoli ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Phenols
In organic chemistry, phenols, sometimes called phenolics, are a class of chemical compounds consisting of one or more hydroxyl groups (— O H) bonded directly to an aromatic hydrocarbon group. The simplest is phenol, . Phenolic compounds are classified as simple phenols or polyphenols based on the number of phenol units in the molecule. Phenols are both synthesized industrially and produced by plants and microorganisms. Properties Acidity Phenols are more acidic than typical alcohols. The acidity of the hydroxyl group in phenols is commonly intermediate between that of aliphatic alcohols and carboxylic acids (their pKa is usually between 10 and 12). Deprotonation of a phenol forms a corresponding negative phenolate ion or phenoxide ion, and the corresponding salts are called phenolates or phenoxides (aryloxides according to the IUPAC Gold Book). Condensation with aldehydes and ketones Phenols are susceptible to Electrophilic aromatic substitutions. Condensation with formald ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
