Ultrasound Localization Microscopy
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Ultrasound Localization Microscopy
Ultrasound Localization Microscopy (ULM) is an advanced ultrasound imaging technique. By localizing microbubbles, ULM overcomes the physical limit of diffraction, achieving sub-wavelength level resolution and qualifying as a super-resolution technique. ULM is primarily utilized in vascular imaging. Because of its deep penetration depth and high resolution, tiny vessels deep within the tissue become visible. This capability gives ULM a significant advantage in diagnosing diseases associated with microvascular development and angiogenesis, such as cancer, diabetes, and certain neurodegenerative diseases. Principle ULM requires multiple image frames that highlight microbubbles (MBs) and approximates the real vasculature by accumulating the located centroids of MBs across the frames. MBs, typically far smaller than the transmitted wavelength, act as point reflectors/emitters of ultrasonic waves, which re-emit waves in a nonlinear fashion. As such, their reflected ultrasound signa ...
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ULM Animation
Ulm () is the sixth-largest city of the southwestern German States of Germany, state of Baden-Württemberg, and with around 129,000 inhabitants, it is Germany's List of cities in Germany by population, 60th-largest city. Ulm is located on the eastern edges of the Swabian Jura mountain range, on the upper course of the River Danube, at the confluence with the small Blau (Danube), Blau Stream, coming from the Blautopf in the west. The mouth of the Iller also falls within Ulm's city limits. The Danube forms the border with Bavaria, where Ulm's twin city Neu-Ulm lies. The city was part of Ulm until 1810, and Ulm and Neu-Ulm have a combined population of around 190,000. Ulm forms an urban district of its own (''Stadtkreis Ulm''), and is the administrative seat of the Alb-Donau-Kreis, the district that surrounds it on three sides, but which the city itself is not a part of. Ulm is the overall 11th-largest List of cities and towns on the river Danube, city on the river Danube, and the ...
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