Transient Receptor Potential Calcium Channel Family
The transient receptor potential Ca2+ channel (TRP-CC) familyTC# 1.A.4 is a member of the Voltage-gated ion channel, voltage-gated ion channel (VIC) superfamily and consists of cation channels conserved from worms to humans. The TRP-CC family also consists of seven subfamilies (TRPC, TRPV, TRPM, TRPN, TRPA, TRPP, and TRPML) based on their amino acid sequence homology: # the canonical or classic TRPs, # the vanilloid receptor TRPs, # the melastatin or long TRPs, # ankyrin (whose only member is the transmembrane protein 1 [TRPA1]) # TRPN after the nonmechanoreceptor potential C (nonpC), and the more distant cousins, # the polycystins # and mucolipins. A representative list of members belonging to the TRP-CC family can be found in thTransporter Classification Database Function Members of the TRP-CC family are characterized as cellular sensors with polymodal activation and gating properties. Many TRP channels are activated by a variety of different stimuli and function as signal ...
[...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]  

Voltage-gated Ion Channel
Voltage-gated ion channels are a class of transmembrane proteins that form ion channels that are activated by changes in the electrical membrane potential near the channel. The membrane potential alters the conformation of the channel proteins, regulating their opening and closing. Cell membranes are generally impermeable to ions, thus they must diffuse through the membrane through transmembrane protein channels. They have a crucial role in excitable cells such as neuronal and muscle tissues, allowing a rapid and co-ordinated depolarization in response to triggering voltage change. Found along the axon and at the synapse, voltage-gated ion channels directionally propagate electrical signals. Voltage-gated ion-channels are usually ion-specific, and channels specific to sodium (Na+), potassium (K+), calcium (Ca2+), and chloride (Cl−) ions have been identified. The opening and closing of the channels are triggered by changing ion concentration, and hence charge gradient, between ...
[...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]