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Time-lapse Microscopy
Time-lapse microscopy is time-lapse photography applied to microscopy. Microscope image sequences are recorded and then viewed at a greater speed to give an accelerated view of the microscopic process. Before the introduction of the video tape recorder in the 1960s, time-lapse microscopy recordings were made on photographic film. During this period, time-lapse microscopy was referred to as microcinematography. With the increasing use of video recorders, the term time-lapse video microscopy was gradually adopted. Today, the term video is increasingly dropped, reflecting that a digital still camera is used to record the individual image frames, instead of a video recorder. Applications Time-lapse microscopy can be used to observe any microscopic object over time. However, its main use is within cell biology to observe artificially cultured cells. Depending on the cell culture, different microscopy techniques can be applied to enhance characteristics of the cells as most cells ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Time-lapse Photography
Time-lapse photography is a technique in which the frequency at which film frames are captured (the frame rate) is much lower than the frequency used to view the sequence. When played at normal speed, time appears to be moving faster and thus ''lapsing''. For example, an image of a scene may be captured at 1 frame per second but then played back at 30 frames per second; the result is an apparent ''30 times'' speed increase. Similarly, film can also be played at a much lower rate than at which it was captured, which slows down an otherwise fast action, as in slow motion or high-speed photography. Processes that would normally appear subtle and slow to the human eye, such as the motion of the sun and stars in the sky or the growth of a plant, become very pronounced. Time-lapse is the extreme version of the cinematography technique of ''undercranking''. Stop motion animation is a comparable technique; a subject that does not actually move, such as a puppet, can repeatedly be move ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aneuploidy
Aneuploidy is the presence of an abnormal number of chromosomes in a cell, for example a human cell having 45 or 47 chromosomes instead of the usual 46. It does not include a difference of one or more complete sets of chromosomes. A cell with any number of complete chromosome sets is called a ''euploid'' cell. An extra or missing chromosome is a common cause of some genetic disorders. Some cancer cells also have abnormal numbers of chromosomes. About 68% of human solid tumors are aneuploid. Aneuploidy originates during cell division when the chromosomes do not separate properly between the two cells (nondisjunction). Most cases of aneuploidy in the autosomes result in miscarriage, and the most common extra autosomal chromosomes among live births are 21, 18 and 13. Chromosome abnormalities are detected in 1 of 160 live human births. Autosomal aneuploidy is more dangerous than sex chromosome aneuploidy, as autosomal aneuploidy is almost always lethal to embryos that cease develo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cell Migration
Cell migration is a central process in the development and maintenance of multicellular organisms. Tissue formation during embryonic development, wound healing and immune responses all require the orchestrated movement of cells in particular directions to specific locations. Cells often migrate in response to specific external signals, including chemical signals and mechanical signals. Errors during this process have serious consequences, including intellectual disability, vascular disease, tumor formation and metastasis. An understanding of the mechanism by which cells migrate may lead to the development of novel therapeutic strategies for controlling, for example, invasive tumour cells. Due to the highly viscous environment (low Reynolds number), cells need to continuously produce forces in order to move. Cells achieve active movement by very different mechanisms. Many less complex prokaryotic organisms (and sperm cells) use flagella or cilia to propel themselves. Eukaryot ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Michael Abercrombie
Michael Abercrombie FRS (14 August 1912 – 28 May 1979) was a British cell biologist and embryologist. He was one of four children of the poet Lascelles Abercrombie. Early life Michael was born at Ryton near Dymock in Gloucestershire on 14 August 1912, the third son of Lascelles Abercrombie, poet and critic, and his wife, Catherine, daughter of Owen Gwatkin, a surgeon at Grange-over-Sands.Dictionary of National Biography 1971-1980 His uncle was the famed British town planner, Patrick Abercrombie. Abercrombie went to school at Liverpool College and then Leeds Grammar School. In 1931 he entered Queen's College, University of Oxford, to study Zoology under Professor Gavin de Beer, supported by a Hastings scholarship. He was awarded a first class B. Sc. degree in 1934. Later life He moved to the Strangeways Research Laboratory at the University of Cambridge to undertake doctoral research. In 1938 was employed at University of Birmingham as a lecturer, while also holding a resea ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fibroblasts
A fibroblast is a type of biological cell that synthesizes the extracellular matrix and collagen, produces the structural framework ( stroma) for animal tissues, and plays a critical role in wound healing. Fibroblasts are the most common cells of connective tissue in animals. Structure Fibroblasts have a branched cytoplasm surrounding an elliptical, speckled nucleus having two or more nucleoli. Active fibroblasts can be recognized by their abundant rough endoplasmic reticulum. Inactive fibroblasts (called fibrocytes) are smaller, spindle-shaped, and have a reduced amount of rough endoplasmic reticulum. Although disjointed and scattered when they have to cover a large space, fibroblasts, when crowded, often locally align in parallel clusters. Unlike the epithelial cells lining the body structures, fibroblasts do not form flat monolayers and are not restricted by a polarizing attachment to a basal lamina on one side, although they may contribute to basal lamina components in s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alexis Carrel
Alexis Carrel (; 28 June 1873 – 5 November 1944) was a French surgeon and biologist who was awarded the Nobel Prize in Physiology or Medicine in 1912 for pioneering vascular suturing techniques. He invented the first perfusion pump with Charles A. Lindbergh opening the way to organ transplantation. His positive description of a miraculous healing he witnessed during a pilgrimage earned him scorn of some of his colleagues. This prompted him to relocate to the United States, where he lived most of his life. He had a leading role in implementing eugenic policies in Vichy France.Sade, Robert M. MD''Alexis Carrel, Pioneer Surgeon''Medical University of South Carolina, Charleston, South Carolina.(see Reggiano (2002) as well as Caillois, p. 107) A Nobel Prize laureate in 1912, Alexis Carrel was also elected twice, in 1924 and 1927, as an honorary member of the Academy of Sciences of the USSR. Biography Born in Sainte-Foy-lès-Lyon, Rhône, Carrel was raised in a devout Catholic fam ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Treponema Pallidum
''Treponema pallidum'', formerly known as ''Spirochaeta pallida'', is a spirochaete bacterium with various subspecies that cause the diseases syphilis, bejel (also known as endemic syphilis), and yaws. It is transmitted only among humans. It is a helically coiled microorganism usually 6–15 μm long and 0.1–0.2 μm wide. ''T. pallidum'''s lack of either a tricarboxylic acid cycle or oxidative phosphorylation results in minimal metabolic activity. The treponemes have a cytoplasmic and an outer membrane. Using light microscopy, treponemes are visible only by using dark field illumination. ''Treponema pallidum'' consists of three subspecies, ''T. p. pallidum, T. p. endemicum,'' and ''T. p. pertenue,'' each of which has a distinct associated disease. Subspecies Three subspecies of ''T. pallidum'' are known: * ''Treponema pallidum pallidum'', which causes syphilis * ''T. p. endemicum'', which causes bejel or endemic syphilis * ''T. p. pertenue'', which causes yaws The ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Brownian Motion
Brownian motion, or pedesis (from grc, πήδησις "leaping"), is the random motion of particles suspended in a medium (a liquid or a gas). This pattern of motion typically consists of random fluctuations in a particle's position inside a fluid sub-domain, followed by a relocation to another sub-domain. Each relocation is followed by more fluctuations within the new closed volume. This pattern describes a fluid at thermal equilibrium, defined by a given temperature. Within such a fluid, there exists no preferential direction of flow (as in transport phenomena). More specifically, the fluid's overall linear and angular momenta remain null over time. The kinetic energies of the molecular Brownian motions, together with those of molecular rotations and vibrations, sum up to the caloric component of a fluid's internal energy (the equipartition theorem). This motion is named after the botanist Robert Brown, who first described the phenomenon in 1827, while looking throu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Victor Henri
Victor Henri (6 June 1872 – 21 June 1940) was a French-Russian Physical chemistry, physical chemist and physiologist. He was born in Marseilles as a son of Russian parents. He is known mainly as an early pioneer in enzyme kinetics. He published more than 500 papers in a variety of disciplines including biochemistry, physical chemistry, psychology, and physiology. Aleksey Krylov was his half-brother. Life Victor Henri's parents were Aleksandra Viktorovna Lyapunova and Nikolay Alexandrovich Krylov, who were not married. His father was married to his mother's sister, Sofiya Viktorovna. At that time, an illegitimate child had no rights if born in Russia, but France was different: if born in France one would be a French citizen. So his parents traveled to Marseilles for his birth. After Victor Henri was born there, Krylov and his legitimate wife then adopted him, and took him back to Saint Petersburg, where he lived with his father, his biological mother, and his adoptive mother. He ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Étienne-Jules Marey
Étienne-Jules Marey (; 5 March 1830, Beaune, Côte-d'Or – 15 May 1904, Paris) was a French scientist, physiologist and chronophotographer. His work was significant in the development of cardiology, physical instrumentation, aviation, cinematography and the science of laboratory photography. He is widely considered to be a pioneer of photography and an influential pioneer of the history of cinema. He was also a pioneer in establishing a variety of graphical techniques for the display and interpretation of quantitative data from physiological measurement. Biography Marey started by studying Circulatory system, blood circulation in the human body. Then he shifted to analyzing heart beats, respiration, muscles (myography), and movement of the body. To aid his studies he developed many instruments for precise measurements. For example, in 1859, in collaboration with the physiologist Auguste Chauveau and the watch manufacturer Breguet (brand), Breguet, he developed a wearable ' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chronophotography
Chronophotography is a photographic technique from the Victorian era which captures a number of phases of movements. The best known chronophotography works were mostly intended for the scientific study of locomotion, to discover practical information for animal handlers and/or as reference material for artists. Although many results were not intended to be exhibited as moving pictures, there is much overlap with the more or less simultaneous quest to register and exhibit photographic motion pictures. Definition Chronophotography is defined as "a set of photographs of a moving object, taken for the purpose of recording and exhibiting successive phases of motion". The term ''chronophotography'' was coined by French physiologist Étienne-Jules Marey to describe photographs of movement from which measurements could be taken and motion could be studied. It is derived from the Greek word χρόνος '' chrónos'' ("time") combined with ''photography''.The J. Paul Getty Museum (1990). ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Cheese Mites
''The Cheese Mites'' ( 1903) is a British short silent documentary film, produced by Charles Urban and directed by F. Martin Duncan. Plot A gentleman is put off his lunch when he holds up a magnifying glass and sees a microscopic view of the cheese mites in his Stilton cheese sandwich. Production background The film "was the sensation of the first public programme of scientific films in Britain shown at the Alhambra Music Hall in Leicester Square, London, in August 1903". According to Michael Brooke of BFI Screenonline, "its claim to being scientific lay in its being shot through a microscope, revealing to a lay audience sights that would normally only have been available to owners of microscopes." Preservation status A complete copy which includes an opening sequence, featuring F. Martin Duncan as the gentleman, was recently discovered uploaded to YouTube under a different title, and has now been acquired by the British Film Institute The British Film Institute (BFI) ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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