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Theiler's Encephalomyelitis Virus
Theiler's murine encephalomyelitis virus (TMEV) is a single-stranded RNA murine cardiovirus from the family ''Picornaviridae''. It has been used as a mouse model for studying virally induced paralysis, as well as encephalomyelitis comparable to multiple sclerosis. Depending on the mouse and viral strain, viral pathogenesis can range from negligible, to chronic or acute encephalomyelitis. Discovery The virus was discovered by virologist Max Theiler in 1937 while working at the Rockefeller University, Rockefeller Institute. Theiler discovered the encephalomyelitis virus during research on poliovirus-like paralysis symptoms in mice. That year Theiler had completed work on developing a vaccine for yellow fever, for which he is best known; in 1951 he received the Nobel Prize for that achievement. Strains The several different strains of TMEV are characterized by their pathology as well as DNA sequencing, genetic sequencing and proteomics. The two major groups are listed below; th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Murine
The Old World rats and mice, part of the subfamily Murinae in the family Muridae, comprise at least 519 species. Members of this subfamily are called murines. In terms of species richness, this subfamily is larger than all mammal families except the Cricetidae and Muridae, and is larger than all mammal orders except the bats and the remainder of the rodents. Description The Murinae are native to Africa, Europe, Asia, and Australia. They are terrestrial placental mammals. They have also been introduced to all continents except Antarctica, and are serious pest animals. This is particularly true in island communities where they have contributed to the endangerment and extinction of many native animals. Two prominent murine species have become vital laboratory animals: the brown rat and house mouse are both used as medical subjects. The murines have a distinctive molar pattern that involves three rows of cusps instead of two, the primitive pattern seen most frequent ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |