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Tadatsugu Taniguchi
is a Japanese immunologist known for his pioneer research on Interferons and Interferon regulatory factors. Contribution Taniguchi's work is mostly focused on immunity and oncogenesis, in particular on the mechanisms of signal transduction and gene expression. While working at the Cancer Institute in Tokyo, he conducted breakthrough research on sequencing the cDNA, and identified two cytokine genes, interferon-beta and interleukin-2. These advances helped characterize various cytokines and discover a new family of transcription factors, interferon regulatory factors, which play essential roles in the immune system and cancer. Biography After graduating in biology from the Tokyo University of Education in 1971, Taniguchi worked at the Laboratory of Biochemistry, University of Naples, Italy from 1972 to 1974. He then went to the University of Zurich, where in 1978 he received his doctorate in molecular biology under the supervision of Charles Weissmann. The same year he star ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aridagawa, Wakayama
file:Aragijima003.JPG, 270px, Aragijima rice terraces is a List of towns in Japan, town located in Arida District, Wakayama, Arida District, in central Wakayama Prefecture, Japan. , the town had an estimated population of 25,940 in 10680 households and a population density of 74 persons per km². The total area of the town is . Geography Aridagawa is located in the north-center of Wakayama prefecture, with the Aridagawa River running through the center of the town. Although there are some flatlands along the Aridagawa River, most of the town tends to be mountainous. * Mountains: Mt. Washigamine (589m) * Flatlands: Aridagawa Plain * Rivers: Aridagawa River (Futagawa Dam)It was established on January 1, 2006, by the merger of the towns of Kanaya, Wakayama, Kanaya, Kibi, Wakayama, Kibi and Shimizu, Wakayama, Shimizu, all from Arida District, Wakayama, Arida District. Neighboring municipalities Wakayama Prefecture :Arida, Wakayama, Arida, Kainan, Wakayama, Kainan, Tanabe, Wakayama, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Adjunct Professor
An adjunct professor is a type of academic appointment in higher education who does not work at the establishment full-time. The terms of this appointment and the job security of the tenure vary in different parts of the world, however the general definition is agreed upon. The term "Adjuncting" is a way of referring to a bona-fide part-time faculty member who has worked in an adjunct position for an institution of higher education. Terminology They may also be called an adjunct lecturer, adjunct instructor, or adjunct faculty. Collectively, they may be referred to as contingent academic labor. The rank of sessional lecturer in Canadian universities is similar to the US concept. North America In the United States, an adjunct is, in most cases, a non-tenure-track faculty member. However, it can also be a scholar or teacher whose primary employer is not the school or department with which they have adjunct status. Adjunct professors make up the majority of instructors in high ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The University Of Tokyo
, abbreviated as or UTokyo, is a public research university located in Bunkyō, Tokyo, Japan. Established in 1877, the university was the first Imperial University and is currently a Top Type university of the Top Global University Project by the Japanese government. UTokyo has 10 faculties, 15 graduate schools and enrolls about 30,000 students, about 4,200 of whom are international students. In particular, the number of privately funded international students, who account for more than 80%, has increased 1.75 times in the 10 years since 2010, and the university is focusing on supporting international students. Its five campuses are in Hongō, Komaba, Kashiwa, Shirokane and Nakano. It is considered to be the most selective and prestigious university in Japan. As of 2021, University of Tokyo's alumni, faculty members and researchers include seventeen prime ministers, 18 Nobel Prize laureates, four Pritzker Prize laureates, five astronauts, and a Fields Medalist. Histor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Naples
The University of Naples Federico II ( it, Università degli Studi di Napoli Federico II) is a public university in Naples, Italy. Founded in 1224, it is the oldest public non-sectarian university in the world, and is now organized into 26 departments. It was Europe's first university dedicated to training secular administrative staff, and is one of the oldest academic institutions in continuous operation. Federico II is the third University in Italy by number of students enrolled, but despite its size it is still one of the best universities in Italy and the world, in southern Italy it leads 1st Ranking since it started, being particularly notable for research; in 2015 it was ranked among the top 100 universities in the world by citations per paper. The university is named after its founder Frederick II. In October 2016 the university hosted the first ever Apple IOS Developer Academy and in 2018 the Cisco Digital Transformation Lab. History The university of Naples Federico II ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Interferon Regulatory Factors
Interferon regulatory factors (IRF) are proteins which regulate transcription of interferons (see regulation of gene expression). Interferon regulatory factors contain a conserved N-terminal region of about 120 amino acids, which folds into a structure that binds specifically to the IRF-element (IRF-E) motifs, which is located upstream of the interferon genes. Some viruses have evolved defense mechanisms that regulate and interfere with IRF functions to escape the host immune system. For instance, the remaining parts of the interferon regulatory factor sequence vary depending on the precise function of the protein. The Kaposi sarcoma herpesvirus, KSHV, is a cancer virus that encodes four different IRF-like genes; including vIRF1, which is a transforming oncoprotein that inhibits type 1 interferon activity. In addition, the expression of IRF genes is under epigenetic regulation by promoter DNA methylation. Role in IFN Signaling IRFs primarily regulate type I IFNs in the host a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Transcription Factor
In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence. The function of TFs is to regulate—turn on and off—genes in order to make sure that they are expressed in the desired cells at the right time and in the right amount throughout the life of the cell and the organism. Groups of TFs function in a coordinated fashion to direct cell division, cell growth, and cell death throughout life; cell migration and organization (body plan) during embryonic development; and intermittently in response to signals from outside the cell, such as a hormone. There are up to 1600 TFs in the human genome. Transcription factors are members of the proteome as well as regulome. TFs work alone or with other proteins in a complex, by promoting (as an activator), or blocking (as a repressor) the recruitment of RNA ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Interleukin
Interleukins (ILs) are a group of cytokines (secreted proteins and signal molecules) that are expressed and secreted by white blood cells (leukocytes) as well as some other body cells. The human genome encodes more than 50 interleukins and related proteins. The function of the immune system primarily depends on interleukins, and rare deficiencies of a number of them have been described, all featuring autoimmune diseases or immune deficiency. The majority of interleukins are synthesized by CD4 helper T-lymphocyte, as well as through monocytes, macrophages, and endothelial cells. They promote the development and differentiation of T and B lymphocytes, and hematopoietic cells. Interleukin receptors on astrocytes in the hippocampus are also known to be involved in the development of spatial memories in mice. History and name The name "interleukin" was chosen in 1979, to replace the various different names used by different research groups to designate interleukin 1 (lymphocyte ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Interferon
Interferons (IFNs, ) are a group of signaling proteins made and released by host cells in response to the presence of several viruses. In a typical scenario, a virus-infected cell will release interferons causing nearby cells to heighten their anti-viral defenses. IFNs belong to the large class of proteins known as cytokines, molecules used for communication between cells to trigger the protective defenses of the immune system that help eradicate pathogens. Interferons are named for their ability to "interfere" with viral replication by protecting cells from virus infections. However, virus-encoded genetic elements have the ability to antagonize the IFN response contributing to viral pathogenesis and viral diseases. IFNs also have various other functions: they activate immune cells, such as natural killer cells and macrophages, and they increase host defenses by up-regulating antigen presentation by virtue of increasing the expression of major histocompatibility complex (M ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CDNA
In genetics, complementary DNA (cDNA) is DNA synthesized from a single-stranded RNA (e.g., messenger RNA (mRNA) or microRNA (miRNA)) template in a reaction catalyzed by the enzyme reverse transcriptase. cDNA is often used to express a specific protein in a cell that does not normally express that protein (i.e., heterologous expression), or to sequence or quantify mRNA molecules using DNA based methods (qPCR, RNA-seq). cDNA that codes for a specific protein can be transferred to a recipient cell for expression, often bacterial or yeast expression systems. cDNA is also generated to analyze transcriptomic profiles in bulk tissue, single cells, or single nuclei in assays such as microarrays, qPCR, and RNA-seq. cDNA is also produced naturally by retroviruses (such as HIV-1, HIV-2, simian immunodeficiency virus, etc.) and then integrated into the host's genome, where it creates a provirus. The term ''cDNA'' is also used, typically in a bioinformatics context, to refer to an mR ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tokyo
Tokyo (; ja, 東京, , ), officially the Tokyo Metropolis ( ja, 東京都, label=none, ), is the capital and largest city of Japan. Formerly known as Edo, its metropolitan area () is the most populous in the world, with an estimated 37.468 million residents ; the city proper has a population of 13.99 million people. Located at the head of Tokyo Bay, the prefecture forms part of the Kantō region on the central coast of Honshu, Japan's largest island. Tokyo serves as Japan's economic center and is the seat of both the Japanese government and the Emperor of Japan. Originally a fishing village named Edo, the city became politically prominent in 1603, when it became the seat of the Tokugawa shogunate. By the mid-18th century, Edo was one of the most populous cities in the world with a population of over one million people. Following the Meiji Restoration of 1868, the imperial capital in Kyoto was moved to Edo, which was renamed "Tokyo" (). Tokyo was devastate ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene Expression
Gene expression is the process by which information from a gene is used in the synthesis of a functional gene product that enables it to produce end products, protein or non-coding RNA, and ultimately affect a phenotype, as the final effect. These products are often proteins, but in non-protein-coding genes such as transfer RNA (tRNA) and small nuclear RNA (snRNA), the product is a functional non-coding RNA. Gene expression is summarized in the central dogma of molecular biology first formulated by Francis Crick in 1958, further developed in his 1970 article, and expanded by the subsequent discoveries of reverse transcription and RNA replication. The process of gene expression is used by all known life—eukaryotes (including multicellular organisms), prokaryotes (bacteria and archaea), and utilized by viruses—to generate the macromolecular machinery for life. In genetics, gene expression is the most fundamental level at which the genotype gives rise to the phenotype, '' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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