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TSLP
Thymic stromal lymphopoietin (TSLP) is a protein belonging to the cytokine family. It is known to play an important role in the maturation of T cell populations through activation of antigen-presenting cells. TSLP is produced mainly by non-Haematopoiesis, hematopoietic cells such as fibroblasts, epithelium, epithelial cells and different types of stromal cell, stromal or stromal-like cells. Gene ontology TSLP production has been observed in various species, including humans and mice. In humans TSLP is encoded by the ''TSLP'' gene. Alternative splicing of this gene results in two transcript variants. Function It mainly impacts myeloid cells and induces the release of T cell A T cell is a type of lymphocyte. T cells are one of the important white blood cells of the immune system and play a central role in the adaptive immune response. T cells can be distinguished from other lymphocytes by the presence of a T-cell r ...-attracting chemokines from monocytes and enhances ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tezepelumab
Tezepelumab, sold under the brand name Tezspire, is a human monoclonal antibody used for the treatment of asthma. Tezepelumab blocks thymic stromal lymphopoietin (TSLP), an epithelial cytokine that has been suggested to be critical in the initiation and persistence of airway inflammation. The most common side effects include arthralgia (joint pain) and pharyngitis (sore throat). Tezepelumab was approved for medical use in the United States in December 2021, and in the European Union in September 2022. The U.S. Food and Drug Administration considers it to be a first-in-class medication. Medical uses Tezepelumab is indicated for the add-on maintenance treatment of people aged twelve years and older with severe asthma. History Two main studies including over 1,500 adults and adolescents with inadequately controlled asthma showed that tezepelumab was effective in reducing the number of severe asthma flare‑ups. Society and culture Legal status On 21 July 2022, the Commit ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CRLF2
Cytokine receptor-like factor 2 is a protein that in humans is encoded by the ''CRLF2'' gene. It forms a ternary signaling complex with TSLP and interleukin-7 receptor-α, capable of stimulating cell proliferation through activation of STAT3, STAT5 and JAK2 pathways and is implicated in the development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) (chromosome 14), or with P2Y purinoceptor 8 gene (P2RY8) (chromosome X or Y) is associated with B-progenitor- and Down syndrome- acute lymphoblastic leukemia (ALL). Cytokine signals are mediated through specific receptor complexes, the components of which are mostly members of the type I cytokine receptor family. Type I cytokine receptors share conserved structural features in their extracellular domain. Receptor complexes are typically heterodimeric, consisting of alpha chains, which provide ligand specificity, and beta (or gamma) chains, which are required for the formation of high- ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Interleukin-7 Receptor-α
Interleukin-7 receptor subunit alpha (IL7R-α) also known as CD127 (Cluster of Differentiation 127) is a protein that in humans is encoded by the ''IL7R'' gene. IL7R-α is a type I cytokine receptor and is a subunit of the functional Interleukin-7 receptor and Thymic Stromal Lymphopoietin Thymic stromal lymphopoietin (TSLP) is a protein belonging to the cytokine family. It is known to play an important role in the maturation of T cell populations through activation of antigen-presenting cells. TSLP is produced mainly by non-hemat ... ( TSLP) receptors. References Further reading * * * * * * * * * * * * * * * * External links * * * Type I cytokine receptors Clusters of differentiation {{membrane-protein-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Regulatory T Cell
The regulatory T cells (Tregs or Treg cells), formerly known as suppressor T cells, are a subpopulation of T cells that modulate the immune system, maintain tolerance to self-antigens, and prevent autoimmune disease. Treg cells are immunosuppressive and generally suppress or downregulate induction and proliferation of effector T cells. Treg cells express the biomarkers CD4, FOXP3, and CD25 and are thought to be derived from the same lineage as naïve CD4+ cells. Because effector T cells also express CD4 and CD25, Treg cells are very difficult to effectively discern from effector CD4+, making them difficult to study. Research has found that the cytokine transforming growth factor beta (TGF-β) is essential for Treg cells to differentiate from naïve CD4+ cells and is important in maintaining Treg cell homeostasis. Mouse models have suggested that modulation of Treg cells can treat autoimmune disease and cancer and can facilitate orga ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
