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TAS-108
TAS-108, also known as SR-16234, is a drug discovered by Masato Tanabe and under development by SRI International and Taiho Pharmaceutical. It is a steroid hormone that has shown signs of treating and preventing breast cancer, even in patients where tamoxifen has failed. Development Masato Tanabe's team at SRI has focused on the development of steroid hormones. A compound discovered in a previous SRI contract from the National Institutes of Health showed potential – it acted like "anti-estrogen" in the breasts and uterus but like normal estrogen elsewhere in the body, and was more "tissue-selective". A contract was proposed to Taiho Pharmaceutical in July 1996, and within six years and slightly under $3 million (an unusually short amount of time), two new drugs were discovered and tested on people (particularly people for which tamoxifen has failed): SR-16234 and SR-16287. The first of those, SR-16234, also inhibited the growth of blood vessels angiogenesis and accelerated th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Masato Tanabe
Masato "Mas" Tanabe was a drug researcher at SRI International, where he spent 45 years studying steroid hormones, which are instrumental in combatting breast cancer and prostate cancer. Education Tanabe graduated from the University of San Francisco in 1947 with a degree in chemistry; his thesis was "Studies in the hydroaromatic series". Tanabe would go on to study under professor William G. Dauben at the University of California, Berkeley. Career Tanabe was program manager of Steroid Chemistry group, then director of SRI's Bio-Organic Chemistry Laboratory for much of his career, and later the director of SRI's Pharmaceutical Chemistry group. In 1967, he was on a team that discovered Eschenmoser-Tanabe fragmentation. Much of the work was sponsored by the National Institute of Health and Schering Plough, the latter of which has at least eight patents and 30 journal articles via work sponsored at SRI. Other notable accomplishments include the use of stable isotopes to study metabol ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |