|
Masato Tanabe
Masato "Mas" Tanabe was a drug researcher at SRI International, where he spent 45 years studying steroid hormones, which are instrumental in combatting breast cancer and prostate cancer. Education Tanabe graduated from the University of San Francisco in 1947 with a degree in chemistry; his thesis was "Studies in the hydroaromatic series". Tanabe would go on to study under professor William G. Dauben at the University of California, Berkeley. Career Tanabe was program manager of Steroid Chemistry group, then director of SRI's Bio-Organic Chemistry Laboratory for much of his career, and later the director of SRI's Pharmaceutical Chemistry group. In 1967, he was on a team that discovered Eschenmoser-Tanabe fragmentation. Much of the work was sponsored by the National Institute of Health and Schering Plough, the latter of which has at least eight patents and 30 journal articles via work sponsored at SRI. Other notable accomplishments include the use of stable isotopes to study metabol ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
SRI International
SRI International (SRI) is an American nonprofit scientific research institute and organization headquartered in Menlo Park, California. The trustees of Stanford University established SRI in 1946 as a center of innovation to support economic development in the region. The organization was founded as the Stanford Research Institute. SRI formally separated from Stanford University in 1970 and became known as SRI International in 1977. SRI performs client-sponsored research and development for government agencies, commercial businesses, and private foundations. It also licenses its technologies, forms strategic partnerships, sells products, and creates spin-off companies. SRI's headquarters are located near the Stanford University campus. SRI's annual revenue in 2014 was approximately $540 million, which tripled from 1998 under the leadership of Curtis Carlson. In 1998, the organization was on the verge of bankruptcy when Carlson took over as CEO. Over the next sixteen years wit ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stable Isotopes
The term stable isotope has a meaning similar to stable nuclide, but is preferably used when speaking of nuclides of a specific element. Hence, the plural form stable isotopes usually refers to isotopes of the same element. The relative abundance of such stable isotopes can be measured experimentally (isotope analysis), yielding an isotope ratio that can be used as a research tool. Theoretically, such stable isotopes could include the radiogenic daughter products of radioactive decay, used in radiometric dating. However, the expression stable-isotope ratio is preferably used to refer to isotopes whose relative abundances are affected by isotope fractionation in nature. This field is termed stable isotope geochemistry. Stable-isotope ratios Measurement of the ratios of naturally occurring stable isotopes (isotope analysis) plays an important role in isotope geochemistry, but stable isotopes (mostly hydrogen, carbon, nitrogen, oxygen and sulfur) are also finding uses in ecological ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
SRI International People
Shri (; , ) is a Sanskrit term denoting resplendence, wealth and prosperity, primarily used as an honorific. The word is widely used in South and Southeast Asian languages such as Marathi, Malay (including Indonesian and Malaysian), Javanese, Balinese, Sinhala, Thai, Tamil, Telugu, Hindi, Nepali, Malayalam, Kannada, Sanskrit, Pali, Khmer, and also among Philippine languages. It is usually transliterated as ''Sri'', ''Sree'', ''Shri'', Shiri, Shree, ''Si'', or ''Seri'' based on the local convention for transliteration. The term is used in Indian subcontinent and Southeast Asia as a polite form of address equivalent to the English "Mr." in written and spoken language, but also as a title of veneration for deities or as honorific title for local rulers. Shri is also another name for Lakshmi, the Hindu goddess of wealth, while a ''yantra'' or a mystical diagram popularly used to worship her is called Shri Yantra. Etymology Monier-Williams Dictionary gives the meaning of the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Living People
Related categories * :Year of birth missing (living people) / :Year of birth unknown * :Date of birth missing (living people) / :Date of birth unknown * :Place of birth missing (living people) / :Place of birth unknown * :Year of death missing / :Year of death unknown * :Date of death missing / :Date of death unknown * :Place of death missing / :Place of death unknown * :Missing middle or first names See also * :Dead people * :Template:L, which generates this category or death years, and birth year and sort keys. : {{DEFAULTSORT:Living people 21st-century people People by status ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Japan Pharmaceutical Manufacturers Association
The Japan Pharmaceutical Manufacturers Association (JPMA) is the organization representing the research-based pharmaceutical industry operating in Japan. The JPMA has 74 members including 20 overseas affiliates (as of October 1, 2006). See also * Juvenile Products Manufacturers Association (JPMA) * European Federation of Pharmaceutical Industries and Associations (EFPIA) * International Federation of Pharmaceutical Manufacturers Associations (IFPMA) * Pharmaceutical Research and Manufacturers of America (PhRMA) * Portuguese Pharmaceutical Industry Association The Portuguese Pharmaceutical Industry Association (Associação Portuguesa Da Indústria Farmacêutica) is a trade association based in Lisbon. It was established in 1975, succeeding the National Guild of the Manufacturers of Medicinal Products wh ... External links Japan Pharmaceutical Manufacturers Association(JPMA) {{Authority control Pharmaceutical industry trade groups Pharmaceutical companies of Japan ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American Association For Cancer Research
The American Association for Cancer Research (AACR) is the world's oldest and largest professional association related to cancer research. Based in Philadelphia, the AACR focuses on all aspects of cancer research, including basic, clinical, and translational research into the etiology, prevention, diagnosis, and treatment of cancer. Founded in 1907 by 11 physicians and scientists, the organization now has more than 52,000 members in 130 countries and territories. The mission of the AACR is to prevent and cure cancer through research, education, communication, collaboration, science policy and advocacy, and funding for cancer research. History The AACR was founded on May 7, 1907 in Washington, DC as the "Association for Cancer Research" by a group of scientists consisting of four surgeons, five pathologists, and two biochemists. The founding members were Silas P. Beebe, George H. A. Clowes, William Coley, James Ewing, Harvey R. Gaylord, Robert B. Greenough, J. Collins War ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Clinical Cancer Research
''Clinical Cancer Research'' is a peer-reviewed medical journal on oncology, including the cellular and molecular characterization, prevention, diagnosis, and therapy of human cancer, medical and hematological oncology, radiation therapy, pediatric oncology, pathology, surgical oncology, and clinical genetics. The applications of the disciplines of pharmacology, immunology, cell biology, and molecular genetics to intervention in human cancer are also included. One of the main interests of ''Clinical Cancer Research'' is on clinical trials that evaluate new treatments together with research on pharmacology and molecular alterations or biomarkers that predict response or resistance to treatment. Another priority for ''Clinical Cancer Research'' is laboratory and animal studies of new drugs as well as molecule-targeted agents with the potential to lead to clinical trials, and studies of targetable mechanisms of oncogenesis, progression of the malignant phenotype, and metastatic disease. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Apoptosis
Apoptosis (from grc, ἀπόπτωσις, apóptōsis, 'falling off') is a form of programmed cell death that occurs in multicellular organisms. Biochemical events lead to characteristic cell changes (morphology) and death. These changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation, DNA fragmentation, and mRNA decay. The average adult human loses between 50 and 70 billion cells each day due to apoptosis. For an average human child between eight and fourteen years old, approximately twenty to thirty billion cells die per day. In contrast to necrosis, which is a form of traumatic cell death that results from acute cellular injury, apoptosis is a highly regulated and controlled process that confers advantages during an organism's life cycle. For example, the separation of fingers and toes in a developing human embryo occurs because cells between the digits undergo apoptosis. Unlike necrosis, apoptosis produces cell fragments called apoptotic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Angiogenesis
Angiogenesis is the physiological process through which new blood vessels form from pre-existing vessels, formed in the earlier stage of vasculogenesis. Angiogenesis continues the growth of the vasculature by processes of sprouting and splitting. Vasculogenesis is the embryonic formation of endothelial cells from mesoderm cell precursors, and from neovascularization, although discussions are not always precise (especially in older texts). The first vessels in the developing embryo form through vasculogenesis, after which angiogenesis is responsible for most, if not all, blood vessel growth during development and in disease. Angiogenesis is a normal and vital process in growth and development, as well as in wound healing and in the formation of granulation tissue. However, it is also a fundamental step in the transition of tumors from a benign state to a malignant one, leading to the use of angiogenesis inhibitors in the treatment of cancer. The essential role of angiogenesis in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tamoxifen
Tamoxifen, sold under the brand name Nolvadex among others, is a selective estrogen receptor modulator used to prevent breast cancer in women and treat breast cancer in women and men. It is also being studied for other types of cancer. It has been used for Albright syndrome. Tamoxifen is typically taken daily by mouth for five years for breast cancer. Serious side effects include a small increased risk of uterine cancer, stroke, vision problems, and pulmonary embolism. Common side effects include irregular periods, weight loss, and hot flashes. It may cause harm to the baby if taken during pregnancy or breastfeeding. It is a selective estrogen-receptor modulator (SERM) and works by decreasing the growth of breast cancer cells. It is a member of the triphenylethylene group of compounds. Tamoxifen was initially made in 1962, by chemist Dora Richardson. It is on the World Health Organization's List of Essential Medicines. Tamoxifen is available as a generic medication. In 202 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Taiho Pharmaceutical
is a Japanese pharmaceutical company, and a subsidiary of Otsuka Holdings, which focuses on developing cancer treatments. Taiho, headquartered in Tokyo, Japan, is an R&D-driven specialty pharma focusing on the three fields of oncology, allergies and immunology, and urology. Being Japan's second-largest pharmaceutical company by prescription oral oncology sales, Taiho covers oncology related therapeutic areas including stomach cancer, colorectal cancer, pancreatic cancer, and breast cancer. Taiho also engages in research and development, manufacturing, and the marketing of pharmaceutical products. The company is principally active in the prescription market, but also develops over-the-counter medication, and is a full member of the Japan Pharmaceutical Manufacturers Association (JPMA). As of March 2013, Taiho had over 2,500 employees worldwide. The company achieved approximately US$1.3 billion in revenue during the 2012 fiscal year. History 1963 — Taiho Pharmaceutical Co. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
TAS-108
TAS-108, also known as SR-16234, is a drug discovered by Masato Tanabe and under development by SRI International and Taiho Pharmaceutical. It is a steroid hormone that has shown signs of treating and preventing breast cancer, even in patients where tamoxifen has failed. Development Masato Tanabe's team at SRI has focused on the development of steroid hormones. A compound discovered in a previous SRI contract from the National Institutes of Health showed potential – it acted like "anti-estrogen" in the breasts and uterus but like normal estrogen elsewhere in the body, and was more "tissue-selective". A contract was proposed to Taiho Pharmaceutical in July 1996, and within six years and slightly under $3 million (an unusually short amount of time), two new drugs were discovered and tested on people (particularly people for which tamoxifen has failed): SR-16234 and SR-16287. The first of those, SR-16234, also inhibited the growth of blood vessels angiogenesis and accelerated th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
