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TACC1
Transforming acidic coiled-coil-containing protein 1 is a protein that in humans is encoded by the ''TACC1'' gene. Function The function of this gene has not yet been determined; however, it is speculated that it may represent a breast cancer candidate gene. It is located close to FGFR1 on a region of chromosome 8 that is amplified in some breast cancers. Interactions TACC1 has been shown to interact with: * Aurora A kinase, * Aurora B kinase, * BARD1, * CKAP5, * LSM7, * SNRPG, and * TDRD7 Tudor domain-containing protein 7 is a protein that in humans is encoded by the ''TDRD7'' gene. In melanocytic cells TDRD7 gene expression may be regulated by MITF. Gene polymorphism Various single nucleotide polymorphisms (SNPs) of the TDRD7 .... References Further reading * * * * * * * * * * * * * * * * {{gene-8-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CKAP5
Cytoskeleton-associated protein 5 is a microtubule-associated protein that in humans is encoded by the ''CKAP5'' gene. It is the homolog of the ''Xenopus'' protein XMAP215 and is also known as ch-Tog. It has at least two distinct roles in spindle formation: it protects kinetochore microtubules from depolymerization by MCAK (KIF2C), and ch-Tog plays an essential role in centrosomal microtubule assembly, a function independent of MCAK activity. Interactions CKAP5 has been shown to interact with TACC1 Transforming acidic coiled-coil-containing protein 1 is a protein that in humans is encoded by the ''TACC1'' gene. Function The function of this gene has not yet been determined; however, it is speculated that it may represent a breast cancer .... References External links * Further reading * * * * * * * * * * * {{gene-11-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aurora A Kinase
Aurora kinase A also known as serine/threonine-protein kinase 6 is an enzyme that in humans is encoded by the ''AURKA'' gene. Aurora A is a member of a family of mitotic serine/threonine kinases. It is implicated with important processes during mitosis and meiosis whose proper function is integral for healthy cell proliferation. Aurora A is activated by one or more phosphorylations and its activity peaks during the G2 phase to M phase transition in the cell cycle. Discovery The aurora kinases were first identified in 1990 during a cDNA screen of ''Xenopus'' eggs. The kinase discovered, Eg2, is now referred to as Aurora A. It was not until 1998, however, that Aurora A's meiotic and mitotic importance was realized. Aurora kinase family The human genome contains three members of the aurora kinase family: Aurora kinase A, Aurora kinase B and Aurora C kinase. The ''Xenopus'', ''Drosophila'', and ''Caenorhabditis elegans'' genomes, on the other hand, contain orthologues on ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
LSM7
U6 snRNA-associated Sm-like protein LSm7 is a protein that in humans is encoded by the ''LSM7'' gene. Function Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing. upplied by OMIMref name="entrez"> Interactions LSM7 has been shown to interact with TACC1 and LSM2 U6 snRNA-associated Sm-like protein LSm2 is a protein that in humans is encoded by the ''LSM2'' gene. Function Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 60 .... References Further reading * * * * * * * * {{gene-19-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
SNRPG
Small nuclear ribonucleoprotein G is a protein that in humans is encoded by the ''SNRPG'' gene. Interactions SNRPG has been shown to interact with DDX20 and TACC1 Transforming acidic coiled-coil-containing protein 1 is a protein that in humans is encoded by the ''TACC1'' gene. Function The function of this gene has not yet been determined; however, it is speculated that it may represent a breast cancer .... References Further reading * * * * * * * * * * * * * * * * External links * {{gene-2-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aurora B Kinase
Aurora kinase B is a protein that functions in the attachment of the mitotic spindle to the centromere. Function Chromosomal segregation during mitosis as well as meiosis is regulated by kinases and phosphatases. The Aurora kinases associate with microtubules during chromosome movement and segregation. Aurora kinase B localizes to microtubules near kinetochores, specifically to the specialized microtubules called K-fibers, and Aurora kinase A (MIM 603072) localizes to centrosomes (Lampson et al., 2004).[supplied by OMIM] In cancerous cells, over-expression of these enzymes causes unequal distribution of genetic information, creating aneuploidy, aneuploid cells, a hallmark of cancer. Discovery In 1998, Aurora kinase B was identified in humans by a polymerase chain reaction screen for kinases that are overexpressed in cancers. In the same year, rat Aurora kinase B was identified in a screen designed to find kinases that altered S. cerevisiae proliferation when overexpressed. E ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
BARD1
BRCA1-associated RING domain protein 1 is a protein that in humans is encoded by the ''BARD1'' gene. The human BARD1 protein is 777 amino acids long and contains a RING finger domain (residues 46-90), four ankyrin repeats (residues 420-555), and two tandem BRCT domains (residues 568-777). Function Most, if not all, BRCA1 heterodimerizes with BARD1 in vivo. BARD1 and BRCA1 form a heterodimer via their N-terminal RING finger domains. The BARD1-BRCA1 interaction is observed in vivo and in vitro and is essential for BRCA1 stability. BARD1 shares homology with the two most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes, and developmentally important genes such as the polycomb group of genes. The BARD1 protein also contains three tandem ankyrin repeats. The BARD1/BRCA1 i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific 3D structure that determines its activity. A linear chain of amino acid residues is called a polypeptide. A protein contains at least one long polypeptide. Short polypeptides, containing less than 20–30 residues, are rarely considered to be proteins and are commonly called peptides. The individual amino acid residues are bonded together by peptide bonds and adjacent amino acid residues. The sequence of amino acid residue ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a basic unit of heredity and the molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protein-coding genes and noncoding genes. During gene expression, the DNA is first copied into RNA. The RNA can be directly functional or be the intermediate template for a protein that performs a function. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic traits. These genes make up different DNA sequences called genotypes. Genotypes along with environmental and developmental factors determine what the phenotypes will be. Most biological traits are under the influence of polygenes (many different genes) as well as gen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
