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Tse Wen Chang
Tse Wen Chang (, born August 25, 1947) is an immunology researcher, whose career spans across academia and industry. His early research involving the Immunoglobulin E (IgE) pathway and antibody-based therapeutics lead to the development of omalizumab (also known as Xolair), a medication that has been approved for the treatment of severe allergic asthma and severe chronic spontaneous urticaria. Chang is a cofounder of Tanox, a biopharmaceutical company specialized in anti-IgE therapies for the treatment of allergic diseases. After Tanox's tripartite partnership with Genentech and Novartis was forged in 1996, Chang returned to his alma mater, the National Tsing Hua University in Taiwan and served as the Dean (1996–1999) of the College of Life Sciences. Chang was appointed by the Taiwanese government as President of the Development Center for Biotechnology (DCB) in 2000, and served as a Science and Technology Advisor of the Executive Yuan from 2002 to 2006. From 2006 to 2016, he wa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Zhongli District
Zhongli District () is a District (Taiwan), district in Taoyuan City, Taiwan. Zhongli is spelled variously as ''Jungli'', ''Jongli'', ''Jhongli'' or ''Chungli'' on railway stations, bus stops and road signs. Historically, the city is the site of the Zhongli Incident of 1977, the most significant event of the democratization movement prior to the 1980s. Ethnically, it is considered a capital city for Hakka Taiwanese, who live in great numbers here and in surrounding areas; many elderly persons can speak Hakka Chinese, Hakka in addition to Standard Chinese, Mandarin and Taiwanese Hokkien. In recent years many foreign workers (mainly from the Overseas Filipino Worker, Philippines and Thailand) have also settled in and around the city due to the heavy industry in the suburbs of the city, making it a center for foreign laborers. The district of Zhongli has three large parks and over 70 green reserves. Zhongli District is the busiest district in Southern Taoyuan (南桃園), as well as t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genentech
Genentech, Inc., is an American biotechnology corporation headquartered in South San Francisco, California. It became an independent subsidiary of Roche in 2009. Genentech Research and Early Development operates as an independent center within Roche. Historically, the company is regarded as the world's first biotechnology company. As of July 2021, Genentech employed 13,539 people. History The company was founded in 1976 by venture capitalist Robert A. Swanson and biochemist Herbert Boyer. Boyer is considered to be a pioneer in the field of recombinant DNA technology. In 1973, Boyer and his colleague Stanley Norman Cohen demonstrated that restriction enzymes could be used as "scissors" to cut DNA fragments of interest from one source, to be ligated into a similarly cut plasmid vector. While Cohen returned to the laboratory in academia, Swanson contacted Boyer to found the company. Boyer worked with Arthur Riggs and Keiichi Itakura from the Beckman Research Institute, and the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Peanut Allergy
Peanut allergy is a type of food allergy to peanuts. It is different from tree nut allergies, because peanuts are legumes and not true nuts. Physical symptoms of allergic reaction can include itchiness, hives, swelling, eczema, sneezing, asthma attack, abdominal pain, drop in blood pressure, diarrhea, and cardiac arrest. Anaphylaxis may occur. Those with a history of asthma are more likely to be severely affected. It is due to a type I hypersensitivity reaction of the immune system in susceptible individuals. The allergy is recognized "as one of the most severe food allergies due to its prevalence, persistency, and potential severity of allergic reaction." Prevention may be partly achieved through early introduction of peanuts to the diets of pregnant women and babies. It is recommended that babies at high risk be given peanut products in areas where medical care is available as early as 4 months of age. The principal treatment for anaphylaxis is the injection of epineph ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Allergic Rhinitis
Allergic rhinitis, of which the seasonal type is called hay fever, is a type of inflammation in the nose that occurs when the immune system overreacts to allergens in the air. Signs and symptoms include a runny or stuffy nose, sneezing, red, itchy, and watery eyes, and swelling around the eyes. The fluid from the nose is usually clear. Symptom onset is often within minutes following allergen exposure, and can affect sleep and the ability to work or study. Some people may develop symptoms only during specific times of the year, often as a result of pollen exposure. Many people with allergic rhinitis also have asthma, allergic conjunctivitis, or atopic dermatitis. Allergic rhinitis is typically triggered by environmental allergens such as pollen, pet hair, dust, or mold. Inherited genetics and environmental exposures contribute to the development of allergies. Growing up on a farm and having multiple siblings decreases this risk. The underlying mechanism involves IgE antibodies ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Talizumab
Talizumab (TNX-901) is a humanized monoclonal antibody that was under development by Tanox in Houston, Texas as a new-concept therapeutic for allergic diseases. The unique anti-IgE antibody was designed to target immunoglobulin E (IgE) and IgE-expressing B lymphocytes specifically, without binding to IgE already bound by the high affinity IgE receptors on mast cells and basophils. Talizumab was tested in clinical trials at National Jewish Medical and Research Center and other medical centers and allergy clinics across the U. S. and shown to be able to prevent allergic reactions to accidental exposure to peanuts, which is contained in many kinds of foods. History The U.S. Food and Drug Administration (FDA) " fast-tracked" TNX-901. A drug is given a fast-track status if it meets a medical need not currently being met by any medication. TNX-901 was developed by Houston-based Tanox, started by two biomedical scientists, Nancy T. Chang and Tse Wen Chang, in 1986. There was a legal d ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Food And Drug Administration
The United States Food and Drug Administration (FDA or US FDA) is a List of United States federal agencies, federal agency of the United States Department of Health and Human Services, Department of Health and Human Services. The FDA is responsible for protecting and promoting public health through the control and supervision of food safety, tobacco products, caffeine products, dietary supplements, Prescription drug, prescription and Over-the-counter drug, over-the-counter pharmaceutical drugs (medications), vaccines, biopharmaceuticals, blood transfusions, medical devices, electromagnetic radiation emitting devices (ERED), cosmetics, Animal feed, animal foods & feed and Veterinary medicine, veterinary products. The FDA's primary focus is enforcement of the Federal Food, Drug, and Cosmetic Act (FD&C), but the agency also enforces other laws, notably Section 361 of the Public Health Service Act, as well as associated regulations. Much of this regulatory-enforcement work is not d ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Herman Eisen
Herman Nathaniel Eisen (October 15, 1918 – November 2, 2014) was an American immunologist and cancer researcher. He served on the faculty at New York University School of Medicine in the early 1950s, became the Chief of Dermatology at the Washington University School of Medicine in 1955, and was a founding member of the MIT Center for Cancer Research (now called the Koch Institute for Integrative Cancer Research). Eisen retired and assumed professor emeritus status in 1989, but continued to be active as a researcher; he was working on a manuscript the day he died in 2014. Early life and education Eisen was born in Brooklyn, New York, in 1918, one of four children of Jewish immigrants from Eastern Europe. His undergraduate studies at New York University began in 1934 but were interrupted by a case of tuberculosis, which required him to withdraw from school for a year; he later recalled this as a key event in his life inspiring him to focus on intellectual activities. After gradu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
T Cell
A T cell is a type of lymphocyte. T cells are one of the important white blood cells of the immune system and play a central role in the adaptive immune response. T cells can be distinguished from other lymphocytes by the presence of a T-cell receptor (TCR) on their cell surface. T cells are born from hematopoietic stem cells, found in the bone marrow. Developing T cells then migrate to the thymus gland to develop (or mature). T cells derive their name from the thymus. After migration to the thymus, the precursor cells mature into several distinct types of T cells. T cell differentiation also continues after they have left the thymus. Groups of specific, differentiated T cell subtypes have a variety of important functions in controlling and shaping the immune response. One of these functions is immune-mediated cell death, and it is carried out by two major subtypes: CD8+ "killer" and CD4+ "helper" T cells. (These are named for the presence of the cell surface proteins CD8 or ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein Degradation
Proteolysis is the breakdown of proteins into smaller polypeptides or amino acids. Uncatalysed, the hydrolysis of peptide bonds is extremely slow, taking hundreds of years. Proteolysis is typically catalysed by cellular enzymes called proteases, but may also occur by intra-molecular digestion. Proteolysis in organisms serves many purposes; for example, digestive enzymes break down proteins in food to provide amino acids for the organism, while proteolytic processing of a polypeptide chain after its synthesis may be necessary for the production of an active protein. It is also important in the regulation of some physiological and cellular processes including apoptosis, as well as preventing the accumulation of unwanted or misfolded proteins in cells. Consequently, abnormality in the regulation of proteolysis can cause disease. Proteolysis can also be used as an analytical tool for studying proteins in the laboratory, and it may also be used in industry, for example in food process ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Taiwan Railways Administration
Taiwan Railways Administration (TRA) is a railway operator in Taiwan. It is an agency of the Ministry of Transportation and Communications, responsible for managing, maintaining, and running conventional passenger and freight railway services on 1097 km of track in Taiwan. Since Taiwan is heavily urbanised with a high population density, railways have played an important part in domestic transportation since the late 19th century. Passenger traffic in 2018 was 231,267,955. The agency's headquarters are in Zhongzheng District, Taipei. Overview Railway services between Keelung and Hsinchu began in 1891 under China's Qing dynasty. Because the railway was completely rebuilt and substantially expanded under the operated by Formosa's Japanese colonial government (1895–1945), the network's Japanese influence and heritage persists. Similarities between the TRA and the Japan Railways (JR) companies can be noted in signal aspects, signage, track layout, fare controls, sta ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Guangdong Province
Guangdong (, ), alternatively romanized as Canton or Kwangtung, is a coastal province in South China on the north shore of the South China Sea. The capital of the province is Guangzhou. With a population of 126.01 million (as of 2020) across a total area of about , Guangdong is the most populous province of China and the 15th-largest by area as well as the second-most populous country subdivision in the world (after Uttar Pradesh in India). Its economy is larger than that of any other province in the nation and the fifth largest sub-national economy in the world with a GDP (nominal) of 1.95 trillion USD (12.4 trillion CNY) in 2021. The Pearl River Delta Economic Zone, a Chinese megalopolis, is a core for high technology, manufacturing and foreign trade. Located in this zone are two of the four top Chinese cities and the top two Chinese prefecture-level cities by GDP; Guangzhou, the capital of the province, and Shenzhen, the first special economic zone in the count ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Meixian District
Meixian (, Hakka: Moiyen), formerly Meihsien, is a district (China), district of Meizhou, Meizhou City, in northeastern Guangdong, Guangdong Province, China. The county is an important Hakka settlement and is the ancestral home of many Hakka descendants living in Taiwan. History Its original name was Chengxiang county () during the southern Han Dynasty where it was first created, all the way to the Song dynasty, Song, Yuan dynasty, Yuan and Ming dynasty, Ming dynasties, and then renamed Jiaying county during the Qing dynasty. It only obtained the name Meixian in 1911 during the Xinhai Revolution. Geography Meixian almost completely surrounds Meizhou's central urban Meijiang District. This is due to the old urban core of Meixian becoming separated from the bulk of the county in the territorial reorganization following the 1949 establishment of the China, People's Republic of China, when it was given equal status. Ethno-linguistic make-up Meixian is noted for its large Hak ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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