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Trudy Mackay
Trudy Frances Charlene Mackay (born 10 September 1952) is the director of Clemson University's Center for Human Genetics located on the campus of the Greenwood (S.C.) Genetic Center. She is recognized as one of the world's leading authorities on the genetics of complex traits. Mackay is also the Self Family Chair in Human Genetics and Professor of Genetics and Biochemistry at Clemson University. Mackay is a member of the National Academy of Sciences (2010). Mackay was formerly the William Neal Reynolds and Distinguished University Professor at North Carolina State University, where she specialized in quantitative genetics. She is responsible for establishing the Drosophila Genetic Reference Panel. Education Mackay received a Bachelor of Science degree in 1974 and Master of Science degree in 1976 in Biology from Dalhousie University. She completed postgraduate study at the University of Edinburgh with a PhD in genetics awarded in 1979 for research supervised by Alan Rober ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Moncton
Moncton (; ) is the most populous city in the Provinces and territories of Canada, Canadian province of New Brunswick. Situated in the Petitcodiac River Valley, Moncton lies at the geographic centre of the The Maritimes, Maritime Provinces. The city has earned the nickname "Hub City" because of its central inland location in the region and its history as a railway and land transportation hub for the Maritimes. As of the 2021 Census, the city had a population of 79,470, a metropolitan population of 157,717 and a land area of . Although the Moncton area was first settled in 1733, Moncton was officially founded in 1766 with the arrival of Pennsylvania German immigrants from Philadelphia. Initially an agricultural settlement, Moncton was not incorporated until 1855. It was named for Lt. Col. Robert Monckton, the British officer who had captured nearby Fort Beauséjour a century earlier. A significant wooden shipbuilding industry had developed in the community by the mid-1840s, allow ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Annual Review Of Genetics
The ''Annual Review of Genetics'' is an annual peer-reviewed scientific review journal published by Annual Reviews. It was established in 1967 and covers all topics related to the genetics of viruses, bacteria, fungi, plants, and animals, including humans. The current editor is Tatjana Piotrowski. As of 2021, ''Journal Citation Reports'' gives the journal a 2020 impact factor of 16.830, ranking it fourth out of 175 journals in the category "Genetics & Heredity". History In 1965, the nonprofit publisher Annual Reviews surveyed geneticists to determine if there was a need for an annual journal that published review articles about recent developments in the field of genetics. Responses to the survey were favorable, with the first volume of the ''Annual Review of Genetics'' published two years later in 1967. Its inaugural editor was Herschel L. Roman. As of 2020, it was published both in print and electronically. It defines its scope as covering various aspects of genetics, includ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Disease
A disease is a particular abnormal condition that negatively affects the structure or function of all or part of an organism, and that is not immediately due to any external injury. Diseases are often known to be medical conditions that are associated with specific signs and symptoms. A disease may be caused by external factors such as pathogens or by internal dysfunctions. For example, internal dysfunctions of the immune system can produce a variety of different diseases, including various forms of immunodeficiency, hypersensitivity, allergies and autoimmune disorders. In humans, ''disease'' is often used more broadly to refer to any condition that causes pain, dysfunction, distress, social problems, or death to the person affected, or similar problems for those in contact with the person. In this broader sense, it sometimes includes injuries, disabilities, disorders, syndromes, infections, isolated symptoms, deviant behaviors, and atypical variations of structur ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Animal Breeding
Animal breeding is a branch of animal science that addresses the evaluation (using best linear unbiased prediction and other methods) of the genetic value (estimated breeding value, EBV) of livestock. Selecting for breeding animals with superior EBV in growth rate, egg, meat, milk, or wool production, or with other desirable traits has revolutionized livestock production throughout the entire world. The scientific theory of animal breeding incorporates population genetics, quantitative genetics, statistics, and recently molecular genetics and is based on the pioneering work of Sewall Wright, Jay Lush, and Charles Roy Henderson, Charles Henderson. Breeding stock Breeding stock is a group of animals used for the purpose of planned breeding. When individuals are looking to breed animals, they look for certain valuable traits in purebred animals, or may intend to use some type of crossbreeding to produce a new type of stock with different, and presumably super abilities in a given area ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Plant Breeding
Plant breeding is the science of changing the traits of plants in order to produce desired characteristics. It has been used to improve the quality of nutrition in products for humans and animals. The goals of plant breeding are to produce crop varieties that boast unique and superior traits for a variety of applications. The most frequently addressed agricultural traits are those related to biotic and abiotic stress tolerance, grain or biomass yield, end-use quality characteristics such as taste or the concentrations of specific biological molecules (proteins, sugars, lipids, vitamins, fibers) and ease of processing (harvesting, milling, baking, malting, blending, etc.). Plant breeding can be performed through many different techniques ranging from simply selecting plants with desirable characteristics for propagation, to methods that make use of knowledge of genetics and chromosomes, to more complex molecular techniques. Genes in a plant are what determine what type of qualit ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Model Organism
A model organism (often shortened to model) is a non-human species that is extensively studied to understand particular biological phenomena, with the expectation that discoveries made in the model organism will provide insight into the workings of other organisms. Model organisms are widely used to research human disease when human experimentation would be unfeasible or unethical. This strategy is made possible by the common descent of all living organisms, and the conservation of metabolic and developmental pathways and genetic material over the course of evolution. Studying model organisms can be informative, but care must be taken when generalizing from one organism to another. In researching human disease, model organisms allow for better understanding the disease process without the added risk of harming an actual human. The species chosen will usually meet a determined taxonomic equivalency to humans, so as to react to disease or its treatment in a way that resembles ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Drosophilidae
The Drosophilidae are a diverse, cosmopolitan family of flies, which includes species called fruit flies, although they are more accurately referred to as vinegar or pomace flies. Another distantly related family of flies, Tephritidae, are true fruit flies because they are frugivorous, and include apple maggot flies and many pests. The best known species of the Drosophilidae is ''Drosophila melanogaster'', within the genus ''Drosophila'', also called the "fruit fly." ''Drosophila melanogaster'' is used extensively for studies concerning genetics, development, physiology, ecology and behaviour. Many fundamental biological mechanisms were discovered first in ''D. melanogaster.'' The fruit fly is mostly composed of post-mitotic cells, has a very short lifespan, and shows gradual aging. As in other species, temperature influences the life history of the animal. Several genes have been identified that can be manipulated to extend the lifespan of these insects. Additionally, ''Drosophi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mutation
In biology, a mutation is an alteration in the nucleic acid sequence of the genome of an organism, virus, or extrachromosomal DNA. Viral genomes contain either DNA or RNA. Mutations result from errors during DNA or viral replication, mitosis, or meiosis or other types of damage to DNA (such as pyrimidine dimers caused by exposure to ultraviolet radiation), which then may undergo error-prone repair (especially microhomology-mediated end joining), cause an error during other forms of repair, or cause an error during replication (translesion synthesis). Mutations may also result from insertion or deletion of segments of DNA due to mobile genetic elements. Mutations may or may not produce detectable changes in the observable characteristics (phenotype) of an organism. Mutations play a part in both normal and abnormal biological processes including: evolution, cancer, and the development of the immune system, including junctional diversity. Mutation is the ultimate source o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Continuous Or Discrete Variable
In mathematics and statistics, a quantitative variable may be continuous or discrete if they are typically obtained by ''measuring'' or ''counting'', respectively. If it can take on two particular real values such that it can also take on all real values between them (even values that are arbitrarily close together), the variable is continuous in that interval. If it can take on a value such that there is a non-infinitesimal gap on each side of it containing no values that the variable can take on, then it is discrete around that value. In some contexts a variable can be discrete in some ranges of the number line and continuous in others. Continuous variable A continuous variable is a variable whose value is obtained by measuring, i.e., one which can take on an uncountable set of values. For example, a variable over a non-empty range of the real numbers is continuous, if it can take on any value in that range. The reason is that any range of real numbers between a and b wit ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Phenotypic Trait
A phenotypic trait, simply trait, or character state is a distinct variant of a phenotypic characteristic of an organism; it may be either inherited or determined environmentally, but typically occurs as a combination of the two.Lawrence, Eleanor (2005) ''Henderson's Dictionary of Biology''. Pearson, Prentice Hall. For example, having eye color is a ''character'' of an organism, while blue, brown and hazel versions of eye colour are ''traits''. The term ''trait'' is generally used in genetics, often to describe phenotypic expression of different combinations of alleles in different individual organisms within a single population, such as the famous purple vs. white flower coloration in Gregor Mendel's pea plants. By contrast, in systematics, the term is ''character state'' is employed to describe features that represent fixed diagnostic differences among taxa, such as the absence of tails in great apes, relative to other primate groups. Definition A phenotypic trait is ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Quantitative Trait
Complex traits, also known as quantitative traits, are traits that do not behave according to simple Mendelian inheritance laws. More specifically, their inheritance cannot be explained by the genetic segregation of a single gene. Such traits show a continuous range of variation and are influenced by both environmental and genetic factors. Compared to strictly Mendelian traits, complex traits are far more common, and because they can be hugely polygenic, they are studied using statistical techniques such as QTL mapping rather than classical genetics methods. Examples of complex traits include height, circadian rhythms, enzyme kinetics, and many diseases including diabetes and Parkinson's disease. One major goal of genetic research today is to better understand the molecular mechanisms through which genetic variants act to influence complex traits. History When Mendel’s work on inheritance was rediscovered in 1900, scientists debated whether Mendel’s laws could account for t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genetics
Genetics is the study of genes, genetic variation, and heredity in organisms.Hartl D, Jones E (2005) It is an important branch in biology because heredity is vital to organisms' evolution. Gregor Mendel, a Moravian Augustinian friar working in the 19th century in Brno, was the first to study genetics scientifically. Mendel studied "trait inheritance", patterns in the way traits are handed down from parents to offspring over time. He observed that organisms (pea plants) inherit traits by way of discrete "units of inheritance". This term, still used today, is a somewhat ambiguous definition of what is referred to as a gene. Trait inheritance and molecular inheritance mechanisms of genes are still primary principles of genetics in the 21st century, but modern genetics has expanded to study the function and behavior of genes. Gene structure and function, variation, and distribution are studied within the context of the cell, the organism (e.g. dominance), and within the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
