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Translational Research Institute For Space Health
The Translational Research Institute for Space Health (TRISH) is a virtual, applied research consortium that pursues and funds translational research and technologies to keep astronauts healthy during space exploration, with the added benefit of potential applications on Earth. TRISH is specifically focused on human health in preparation for deep space exploration efforts, including National Aeronautics and Space Administration's (NASA) Artemis missions to the Moon, and future human missions to Mars. TRISH also supports research to collect and study biometric data gathered on commercial spaceflight missions to better understand the effect of spaceflight on the human body. The consortium is led by Baylor College of Medicine, and includes Massachusetts Institute of Technology, and California Institute of Technology, with funding awarded to scientists and organizations around the United States. TRISH works directly with NASA’s Human Research Program (HRP) to establish and coordin ...
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Applied Science
Applied science is the use of the scientific method and knowledge obtained via conclusions from the method to attain practical goals. It includes a broad range of disciplines such as engineering and medicine. Applied science is often contrasted with basic science, which is focused on advancing scientific theories and laws that explain and predict events in the natural world. Applied science can also apply formal science, such as statistics and probability theory, as in epidemiology. Genetic epidemiology is an applied science applying both biological and statistical methods. Applied research Applied research is the practical application of science. It accesses and uses accumulated theories, knowledge, methods, and techniques, for a specific state-, business-, or client-driven purpose. Applied Research can be better understood in any area when contrasting it with, basic, or pure, research. Basic geography research strives to create new theories and methods that aid in the expl ...
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Houston
Houston (; ) is the most populous city in Texas, the most populous city in the Southern United States, the fourth-most populous city in the United States, and the sixth-most populous city in North America, with a population of 2,304,580 in 2020. Located in Southeast Texas near Galveston Bay and the Gulf of Mexico, it is the seat and largest city of Harris County and the principal city of the Greater Houston metropolitan area, which is the fifth-most populous metropolitan statistical area in the United States and the second-most populous in Texas after Dallas–Fort Worth. Houston is the southeast anchor of the greater megaregion known as the Texas Triangle. Comprising a land area of , Houston is the ninth-most expansive city in the United States (including consolidated city-counties). It is the largest city in the United States by total area whose government is not consolidated with a county, parish, or borough. Though primarily in Harris County, small portions of the ...
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Blood Volume
Blood volume (volemia) is the volume of blood (blood cells and plasma) in the circulatory system of any individual. Humans A typical adult has a blood volume of approximately 5 liters, with females and males having approximately the same blood percentage by weight (approx 7 to 8%) Blood volume is regulated by the kidneys. Blood volume (BV) can be calculated given the hematocrit (HC; the fraction of blood that is red blood cells) and plasma volume (PV), with the hematocrit being regulated via the blood oxygen content regulator: :BV = \frac Blood volume measurement may be used in people with congestive heart failure, chronic hypertension, kidney failure and critical care. The use of relative blood volume changes during dialysis is of questionable utility. Total Blood Volume can be measured manually via the Dual Isotope or Dual Tracer Technique, a classic technique, available since the 1950s. This technique requires double labeling of the blood; that is 2 injections and 2 standar ...
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Muscle Atrophy
Muscle atrophy is the loss of skeletal muscle mass. It can be caused by immobility, aging, malnutrition, medications, or a wide range of injuries or diseases that impact the musculoskeletal or nervous system. Muscle atrophy leads to muscle weakness and causes disability. Disuse causes rapid muscle atrophy and often occurs during injury or illness that requires immobilization of a limb or bed rest. Depending on the duration of disuse and the health of the individual, this may be fully reversed with activity. Malnutrition first causes fat loss but may progress to muscle atrophy in prolonged starvation and can be reversed with nutritional therapy. In contrast, cachexia is a wasting syndrome caused by an underlying disease such as cancer that causes dramatic muscle atrophy and cannot be completely reversed with nutritional therapy. Sarcopenia is age-related muscle atrophy and can be slowed by exercise. Finally, diseases of the muscles such as muscular dystrophy or myopathies can cause ...
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Space Adaptation Syndrome
Space adaptation syndrome (SAS) or space sickness is a condition experienced by as many as half of all space travelers during their adaptation to weightlessness once in orbit. It is the opposite of terrestrial motion sickness since it occurs when the environment and the person appear visually to be in motion relative to one another even though there is no corresponding sensation of bodily movement originating from the vestibular system. Presentation Space motion sickness can lead to degraded astronaut performance. SMS threatens operational requirements, reduces situational awareness, and threatens the safety of those exposed to micro-g environments. Lost muscle mass leads to difficulty with movement, especially when astronauts return to earth. This can pose a safety issue if the need for emergency egress were to arise. Loss of muscle power makes it extremely difficult, if not impossible, for astronauts to climb through emergency egress hatches or create unconventional exit spaces ...
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Radiation Exposure
Radiation is a moving form of energy, classified into ionizing and non-ionizing type. Ionizing radiation is further categorized into electromagnetic radiation (without matter) and particulate radiation (with matter). Electromagnetic radiation consists of photons, which can be thought of as energy packets, traveling in the form of a wave. Examples of electromagnetic radiation includes X-rays and gamma rays (see photo "Types of Electromagnetic Radiation"). These types of radiation can easily penetrate the human body because of high energy. Radiation exposure is a measure of the ionization of air due to ionizing radiation from photons. It is defined as the electric charge freed by such radiation in a specified volume of air divided by the mass of that air. Medical exposure is defined by the International Commission on Radiological Protection as exposure incurred by patients as part of their own medical or dental diagnosis or treatment; by persons, other than those occupationally expos ...
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Gravity
In physics, gravity () is a fundamental interaction which causes mutual attraction between all things with mass or energy. Gravity is, by far, the weakest of the four fundamental interactions, approximately 1038 times weaker than the strong interaction, 1036 times weaker than the electromagnetic force and 1029 times weaker than the weak interaction. As a result, it has no significant influence at the level of subatomic particles. However, gravity is the most significant interaction between objects at the macroscopic scale, and it determines the motion of planets, stars, galaxies, and even light. On Earth, gravity gives weight to physical objects, and the Moon's gravity is responsible for sublunar tides in the oceans (the corresponding antipodal tide is caused by the inertia of the Earth and Moon orbiting one another). Gravity also has many important biological functions, helping to guide the growth of plants through the process of gravitropism and influencing the circ ...
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Effect Of Spaceflight On The Human Body
Venturing into the environment of space can have negative effects on the human body. Significant adverse effects of long-term weightlessness include muscle atrophy and deterioration of the skeleton (spaceflight osteopenia). Other significant effects include a slowing of cardiovascular system functions, decreased production of red blood cells (space anemia), balance disorders, eyesight disorders and changes in the immune system. Additional symptoms include fluid redistribution (causing the " moon-face" appearance typical in pictures of astronauts experiencing weightlessness), loss of body mass, nasal congestion, sleep disturbance, and excess flatulence. Overall, NASA refers to the various deleterious effects of spaceflight on the human body by the acronym RIDGE (i.e., "space radiation, isolation and confinement, distance from Earth, gravity fields, and hostile and closed environments"). The engineering problems associated with leaving Earth and developing space propulsion s ...
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The Washington Post
''The Washington Post'' (also known as the ''Post'' and, informally, ''WaPo'') is an American daily newspaper published in Washington, D.C. It is the most widely circulated newspaper within the Washington metropolitan area and has a large national audience. Daily broadsheet editions are printed for D.C., Maryland, and Virginia. The ''Post'' was founded in 1877. In its early years, it went through several owners and struggled both financially and editorially. Financier Eugene Meyer purchased it out of bankruptcy in 1933 and revived its health and reputation, work continued by his successors Katharine and Phil Graham (Meyer's daughter and son-in-law), who bought out several rival publications. The ''Post'' 1971 printing of the Pentagon Papers helped spur opposition to the Vietnam War. Subsequently, in the best-known episode in the newspaper's history, reporters Bob Woodward and Carl Bernstein led the American press's investigation into what became known as the Watergate scandal ...
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Human Space Exploration
Human spaceflight (also referred to as manned spaceflight or crewed spaceflight) is spaceflight with a crew or passengers aboard a spacecraft, often with the spacecraft being operated directly by the onboard human crew. Spacecraft can also be telerobotic, remotely operated from ground stations on Earth, or Autonomous robot, autonomously, without any direct human involvement. People trained for spaceflight are called astronauts (American or other), ''cosmonauts'' (Russian), or ''taikonauts'' (Chinese); and non-professionals are referred to as spaceflight participants or ''spacefarers''. The first human in space was Soviet Union, Soviet cosmonaut Yuri Gagarin, who launched as part of the Soviet Union's Vostok program on Cosmonautics Day, 12 April 1961 at the beginning of the Space Race. On 5 May 1961, Alan Shepard became the first American in space, as part of Project Mercury. Humans traveled to the Moon nine times between 1968 and 1972 as part of the United States' Apollo progra ...
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National Space Biomedical Research Institute
The National Space Biomedical Research Institute (NSBRI) was a NASA-funded consortium of institutions studying the health risks related to long-duration spaceflight and developing solutions to reduce those risks. The NSBRI was founded in 1997 through a NASA Cooperative Agreement. The founding director was Laurence R. Young of MIT. NSBRI's 16,400-square-foot headquarters facility was located in the BioScience Research Collaborative in Houston, Texas. The Institute shared the facility with Baylor College of Medicine's Center for Space Medicine. The official opening was held March 19, 2012. In March 2012 NASA announced a five-year extension of its cooperative agreement with NSBRI. At the end of this period NASA wound down its relationship with NSBRI, which closed in 2017. The consortium was succeeded by the Translational Research Institute for Space Health (TRISH), led by the Baylor College of Medicine. Research programs NSBRI coordinated its research with NASA's Human Research Prog ...
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Biomedical Research
Medical research (or biomedical research), also known as experimental medicine, encompasses a wide array of research, extending from "basic research" (also called ''bench science'' or ''bench research''), – involving fundamental scientific principles that may apply to a ''preclinical'' understanding – to clinical research, which involves studies of people who may be subjects in clinical trials. Within this spectrum is applied research, or translational research, conducted to expand knowledge in the field of medicine. Both clinical and preclinical research phases exist in the pharmaceutical industry's drug development pipelines, where the clinical phase is denoted by the term ''clinical trial''. However, only part of the clinical or preclinical research is oriented towards a specific pharmaceutical purpose. The need for fundamental and mechanism-based understanding, diagnostics, medical devices, and non-pharmaceutical therapies means that pharmaceutical research i ...
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