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Toshifumi Yokota
Toshifumi (Toshi) Yokota ( ja, 横田俊文, Yokota Toshifumi) is a medical scientist and professor of medical genetics at the University of Alberta, where he also holds the titles of the Friends of Garrett Cumming Research & Muscular Dystrophy Canada Endowed Research Chair and the Henri M. Toupin Chair in Neurological Science. He is best known for his studies of antisense oligonucleotide-based therapeutics for muscular dystrophy that led to the development of an FDA-approved drug viltolarsen. His research interests include precision medicine for muscular dystrophy and genetic diseases. He has co-edited two books both published in the Methods in Molecular Biology series from Humana Press, Springer-Nature, and has published more than 100 refereed papers and patents. He is a member of the editorial boards for the International Journal of Molecular Sciences, Genes, Frontiers in Genome Editing, Frontiers in Physiology, and Nucleic Acid Therapeutics, a member of the Medical and Scie ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Morioka
is the capital city of Iwate Prefecture located in the Tōhoku region of northern Japan. On 1 February 2021, the city had an estimated population of 290,700 in 132,719 households, and a population density of . The total area of the city is . Geography Morioka is located in the in central Iwate Prefecture, at the confluence of three rivers, the Kitakami, the Shizukuishi and the Nakatsu. The Kitakami River is the second largest river on the Pacific side of Japan (after the Tone River) and the longest in the Tōhoku region. It runs through the city from north to south and has a number of dams within the city boundaries, including the Shijūshida Dam and Gandō Dam. An active volcano, Mount Iwate, dominates the view to the northwest of the city. Mount Himekami is to the north and Mount Hayachine can sometimes be seen to the southeast. Surrounding municipalities Iwate Prefecture *Hanamaki * Hachimantai * Takizawa * Miyako *Shizukuishi * Kuzumaki * Shiwa *Yahaba * Iwaizumi Demo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Iwate Prefecture
is a prefecture of Japan located in the Tōhoku region of Honshu. It is the second-largest Japanese prefecture at , with a population of 1,210,534 (as of October 1, 2020). Iwate Prefecture borders Aomori Prefecture to the north, Akita Prefecture to the west, and Miyagi Prefecture to the south. Morioka is the capital and largest city of Iwate Prefecture; other major cities include Ichinoseki, Ōshū, and Hanamaki. Located on Japan's Pacific Ocean coast, Iwate Prefecture features the easternmost point of Honshu at Cape Todo, and shares the highest peaks of the Ōu Mountains—the longest mountain range in Japan—at the border with Akita Prefecture. Iwate Prefecture is home to famous attractions such as Morioka Castle, the Buddhist temples of Hiraizumi including Chūson-ji and Mōtsū-ji, the Fujiwara no Sato movie lot and theme park in Ōshū, and the Tenshochi park in Kitakami known for its huge, ancient cherry trees. Iwate has the lowest population density of any prefecture ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Exon Skipping
In molecular biology, exon skipping is a form of RNA splicing used to cause cells to “skip” over faulty or misaligned sections (exons) of genetic code, leading to a truncated but still functional protein despite the genetic mutation. Mechanism Exon skipping is used to restore the reading frame within a gene. Genes are the genetic instructions for creating a protein, and are composed of introns and exons. Exons are the sections of DNA that contain the instruction set for generating a protein; they are interspersed with non-coding regions called introns. The introns are later removed before the protein is made, leaving only the coding exon regions. Splicing naturally occurs in pre-mRNA when introns are being removed to form mature-mRNA that consists solely of exons. Starting in the late 1990s, scientists realized they could take advantage of this naturally occurring cellular splicing to downplay genetic mutations into less harmful ones. The mechanism behind exon skipping is a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neuromuscular Disease
A neuromuscular disease is any disease affecting the peripheral nervous system (PNS), the neuromuscular junction, or skeletal muscle, all of which are components of the motor unit. Damage to any of these structures can cause muscle atrophy and weakness. Issues with sensation can also occur. Neuromuscular diseases can be acquired or genetic. Mutations of more than 500 genes have shown to be causes of neuromuscular diseases. Other causes include nerve or muscle degeneration, autoimmunity, toxins, medications, malnutrition, metabolic derangements, hormone imbalances, infection, nerve compression/entrapment, comprised blood supply, and trauma. Signs and symptoms Symptoms of neuromuscular disease may include numbness, paresthesia, muscle weakness, muscle atrophy, myalgia (muscle pain), and fasciculations (muscle twitches). Causes Neuromuscular disease can be caused by autoimmune disorders, genetic/hereditary disorders and some forms of the collagen disorder Ehlers–Dan ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Alberta Faculty Of Medicine And Dentistry
The Faculty of Medicine and Dentistry at University of Alberta is located in Edmonton, Alberta, Canada. Established in 1913, it is one of the oldest medical schools in Western Canada and is composed of 21 departments, two stand-alone divisions, 9 research groups, and 24 research centers and institutes. Educational, clinical and research activities are conducted in 29 buildings on or near the University of Alberta north campus. The Faculty of Medicine & Dentistry is home to more than 1,400 support staff and 2,760 tenure-track and clinical educators, including six National 3M Teaching Fellows, Canada's most prestigious teaching award for post-secondary instructors. According to an economic impact report conducted in 2013, the Faculty of Medicine & Dentistry generated approximately $2 billion to the Alberta economy in 2012. Education The Faculty of Medicine & Dentistry, in 2018–19, had a research budget of $166 million. The school runs the Scottish-Canadian Medical Programme join ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Japan Society For The Promotion Of Science
The is an Independent Administrative Institution in Japan, established for the purpose of contributing to the advancement of science in all fields of the natural and social sciences and the humanities.JSPSweb page History The Japan Society for the Promotion of Science was founded in 1932 as a non-profit foundation through an endowment granted by Emperor Shōwa. JSPS became a quasi-governmental organization in 1967 under the auspices of the Ministry of Education, Science, Sports and Culture (''Monbusho''), and after 2001 under the Ministry of Education, Culture, Sports, Science and Technology. In 2003, JSPS entered a new phase with its conversion to an Independent Administrative Institution. This new administrative configuration is intended to become a step towards improving the effectiveness and efficiency of JSPS's management, which in turn should help to improve the quality of the services which are offered to individual researchers, universities, and research institutes. Time ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hammersmith Hospital
Hammersmith Hospital, formerly the Military Orthopaedic Hospital, and later the Special Surgical Hospital, is a major teaching hospital in White City, West London. It is part of Imperial College Healthcare NHS Trust in the London Borough of Hammersmith and Fulham, and is associated with the Imperial College Faculty of Medicine. Confusingly the hospital is not in Hammersmith but is located in White City adjacent to Wormwood Scrubs and East Acton. History Origins The hospital's origins begin in 1902, when the Hammersmith Poor Law Guardians decided to erect a new workhouse and infirmary on a site at the north side of Du Cane Road somewhat to the north of Shepherd's Bush. The land, adjacent to Wormwood Scrubs Prison, was purchased for £14,500 from the Ecclesiastical Commissioners. A temporary corrugated iron building was erected on the site in 1902 to provide care for victims of a smallpox epidemic that had taken place in the winter of 1901–2. The buildings were designed by ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Skeletal Muscle
Skeletal muscles (commonly referred to as muscles) are organs of the vertebrate muscular system and typically are attached by tendons to bones of a skeleton. The muscle cells of skeletal muscles are much longer than in the other types of muscle tissue, and are often known as muscle fibers. The muscle tissue of a skeletal muscle is striated – having a striped appearance due to the arrangement of the sarcomeres. Skeletal muscles are voluntary muscles under the control of the somatic nervous system. The other types of muscle are cardiac muscle which is also striated and smooth muscle which is non-striated; both of these types of muscle tissue are classified as involuntary, or, under the control of the autonomic nervous system. A skeletal muscle contains multiple muscle fascicle, fascicles – bundles of muscle fibers. Each individual fiber, and each muscle is surrounded by a type of connective tissue layer of fascia. Muscle fibers are formed from the cell fusion, fusion of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biological Science
Biology is the scientific study of life. It is a natural science with a broad scope but has several unifying themes that tie it together as a single, coherent field. For instance, all organisms are made up of cells that process hereditary information encoded in genes, which can be transmitted to future generations. Another major theme is evolution, which explains the unity and diversity of life. Energy processing is also important to life as it allows organisms to move, grow, and reproduce. Finally, all organisms are able to regulate their own internal environments. Biologists are able to study life at multiple levels of organization, from the molecular biology of a cell to the anatomy and physiology of plants and animals, and evolution of populations.Based on definition from: Hence, there are multiple subdisciplines within biology, each defined by the nature of their research questions and the tools that they use. Like other scientists, biologists use the scientifi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene Therapy
Gene therapy is a medical field which focuses on the genetic modification of cells to produce a therapeutic effect or the treatment of disease by repairing or reconstructing defective genetic material. The first attempt at modifying human DNA was performed in 1980, by Martin Cline, but the first successful nuclear gene transfer in humans, approved by the National Institutes of Health, was performed in May 1989. The first therapeutic use of gene transfer as well as the first direct insertion of human DNA into the nuclear genome was performed by French Anderson in a trial starting in September 1990. It is thought to be able to cure many genetic disorders or treat them over time. Between 1989 and December 2018, over 2,900 clinical trials were conducted, with more than half of them in phase I.Gene Therapy Cli ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genetics
Genetics is the study of genes, genetic variation, and heredity in organisms.Hartl D, Jones E (2005) It is an important branch in biology because heredity is vital to organisms' evolution. Gregor Mendel, a Moravian Augustinian friar working in the 19th century in Brno, was the first to study genetics scientifically. Mendel studied "trait inheritance", patterns in the way traits are handed down from parents to offspring over time. He observed that organisms (pea plants) inherit traits by way of discrete "units of inheritance". This term, still used today, is a somewhat ambiguous definition of what is referred to as a gene. Trait inheritance and molecular inheritance mechanisms of genes are still primary principles of genetics in the 21st century, but modern genetics has expanded to study the function and behavior of genes. Gene structure and function, variation, and distribution are studied within the context of the cell, the organism (e.g. dominance), and within the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Astrophysics
Astrophysics is a science that employs the methods and principles of physics and chemistry in the study of astronomical objects and phenomena. As one of the founders of the discipline said, Astrophysics "seeks to ascertain the nature of the heavenly bodies, rather than their positions or motions in space–''what'' they are, rather than ''where'' they are." Among the subjects studied are the Sun, other stars, galaxies, extrasolar planets, the interstellar medium and the cosmic microwave background. Emissions from these objects are examined across all parts of the electromagnetic spectrum, and the properties examined include luminosity, density, temperature, and chemical composition. Because astrophysics is a very broad subject, ''astrophysicists'' apply concepts and methods from many disciplines of physics, including classical mechanics, electromagnetism, statistical mechanics, thermodynamics, quantum mechanics, relativity, nuclear and particle physics, and atomic and m ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
