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Thomas J. Hudson
Thomas James Hudson, O.C., (born June 12, 1961) is a Canadian genome scientist noted for his leading role in the generation of physical maps of the human and mouse genomes and also his role in the International HapMap Project whose goal is to develop a haplotype map of the human genome. As director of the McGill University and Genome Quebec Innovation Centre, which he established, Hudson and his team have made a number of discoveries in human genetics. These include genes mutated in rare diseases and genes involved in complex diseases such as asthma, type II diabetes and inflammatory bowel disease. In July 2006, he was appointed president and scientific director of the Ontario Institute for Cancer Research. He is also editor-in-chief of the journal ''Human Genetics''. Thomas Hudson is married and has five children. Beginnings and early career Hudson was born in 1961 in Arvida, Quebec, where his father was a chemist for Alcan. He has six sisters including a twin sister. He ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Arvida
Arvida ( ) is a settlement of 12,000 people (2010)Peritz, Ingrid, "Saguenay 'utopia' dreaming big again", ''The Globe and Mail'', 13 November 2010, p. A31 in Quebec, Canada, that is part of the City of Saguenay. Its name is derived from the name of its founder, Arthur Vining Davis, president of the Alcoa aluminum company. Arvida was founded as an industrial city by Alcoa in 1927, when the first aluminum smelter was constructed. Located north of Quebec City, south of the Saguenay River between Chicoutimi and Jonquière, the town was planned from the first day and was developed as a company town, to have a population of about 14,000 inhabitants, four Catholic parishes, and many other denominations, parishes and schools. It was known as "the City Built in 135 Days" and described by ''The New York Times'' as a "model town for working families" on "a North Canada steppe". History In 1912 James B. Duke purchased the rights to the power on the Saguenay River, and in 1925 the Isle Ma ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Haplotype
A haplotype ( haploid genotype) is a group of alleles in an organism that are inherited together from a single parent. Many organisms contain genetic material ( DNA) which is inherited from two parents. Normally these organisms have their DNA organized in two sets of pairwise similar chromosomes. The offspring gets one chromosome in each pair from each parent. A set of pairs of chromosomes is called diploid and a set of only one half of each pair is called haploid. The haploid genotype (haplotype) is a genotype that considers the singular chromosomes rather than the pairs of chromosomes. It can be all the chromosomes from one of the parents or a minor part of a chromosome, for example a sequence of 9000 base pairs. However, there are other uses of this term. First, it is used to mean a collection of specific alleles (that is, specific DNA sequences) in a cluster of tightly linked genes on a chromosome that are likely to be inherited together—that is, they are likely to be con ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Polymerase Chain Reaction
The polymerase chain reaction (PCR) is a method widely used to rapidly make millions to billions of copies (complete or partial) of a specific DNA sample, allowing scientists to take a very small sample of DNA and amplify it (or a part of it) to a large enough amount to study in detail. PCR was invented in 1983 by the American biochemist Kary Mullis at Cetus Corporation; Mullis and biochemist Michael Smith (chemist), Michael Smith, who had developed other essential ways of manipulating DNA, were jointly awarded the Nobel Prize in Chemistry in 1993. PCR is fundamental to many of the procedures used in genetic testing and research, including analysis of Ancient DNA, ancient samples of DNA and identification of infectious agents. Using PCR, copies of very small amounts of DNA sequences are exponentially amplified in a series of cycles of temperature changes. PCR is now a common and often indispensable technique used in medical laboratory research for a broad variety of applications ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Human Genome Project
The Human Genome Project (HGP) was an international scientific research project with the goal of determining the base pairs that make up human DNA, and of identifying, mapping and sequencing all of the genes of the human genome from both a physical and a functional standpoint. It started in 1990 and was completed in 2003. It remains the world's largest collaborative biological project. Planning started after the idea was picked up in 1984 by the US government, the project formally launched in 1990, and was declared essentially complete on April 14, 2003, but included only about 85% of the genome. Level "complete genome" was achieved in May 2021, with a remaining only 0.3% bases covered by potential issues. The final gapless assembly was finished in January 2022. Funding came from the United States government through the National Institutes of Health (NIH) as well as numerous other groups from around the world. A parallel project was conducted outside the government by the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Human Genome
The human genome is a complete set of nucleic acid sequences for humans, encoded as DNA within the 23 chromosome pairs in cell nuclei and in a small DNA molecule found within individual mitochondria. These are usually treated separately as the nuclear genome and the mitochondrial genome. Human genomes include both protein-coding DNA sequences and various types of DNA that does not encode proteins. The latter is a diverse category that includes DNA coding for non-translated RNA, such as that for ribosomal RNA, transfer RNA, ribozymes, small nuclear RNAs, and several types of regulatory RNAs. It also includes promoters and their associated gene-regulatory elements, DNA playing structural and replicatory roles, such as scaffolding regions, telomeres, centromeres, and origins of replication, plus large numbers of transposable elements, inserted viral DNA, non-functional pseudogenes and simple, highly-repetitive sequences. Introns make up a large percentage of non-coding DNA. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Eric Lander
Eric Steven Lander (born February 3, 1957) is an American mathematician and geneticist who served as the 11th director of the Office of Science and Technology Policy and Science Advisor to the President, serving on the presidential Cabinet. Lander is a professor of biology at the Massachusetts Institute of Technology (MIT), a professor of systems biology at Harvard Medical School, a former member of the Whitehead Institute, and the founding director of the Broad Institute. He is a 1987 MacArthur Fellow and Rhodes Scholar. Lander co-chaired President Barack Obama's Council of Advisors on Science and Technology. Lander announced he would resign from the Biden Administration effective February 18, 2022 after allegations surfaced he had engaged in bullying and abusive conduct directed against his subordinates and other White House staff. Early life and education Lander was born in Brooklyn, New York City, to Jewish parents, the son of Rhoda G. Lander, a social studies teacher, and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Medical Doctor
A physician (American English), medical practitioner (Commonwealth English), medical doctor, or simply doctor, is a health professional who practices medicine, which is concerned with promoting, maintaining or restoring health through the study, diagnosis, prognosis and treatment of disease, injury, and other physical and mental impairments. Physicians may focus their practice on certain disease categories, types of patients, and methods of treatment—known as specialities—or they may assume responsibility for the provision of continuing and comprehensive medical care to individuals, families, and communities—known as general practice. Medical practice properly requires both a detailed knowledge of the academic disciplines, such as anatomy and physiology, underlying diseases and their treatment—the ''science'' of medicine—and also a decent competence in its applied practice—the art or ''craft'' of medicine. Both the role of the physician and the meaning o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alcan
Alcan was a Canadian mining company and aluminum manufacturer. It was founded in 1902 as the Northern Aluminum Company, renamed Aluminum Company of Canada in 1925, and Alcan Aluminum in 1966. It took the name Alcan Incorporated in 2001. During that time, it grew to become one of the world's largest aluminum manufacturers. Alcan was purchased by Australian-British multinational Rio Tinto for $38 billion in 2007, becoming Rio Tinto Alcan Inc. in 2008. It was headquartered in Montreal, in its Maison Alcan complex. History The Northern Aluminum Company Limited was founded in 1902, in Shawinigan, Quebec, as part of the Pittsburgh Reduction Company. In 1913, the company opened a kitchen utensil production plant and foundry in Toronto. It opened a rolling mill in the plant a few years later. During World War I (1914–18), aluminum production increased to 131,000 tonnes from 69,000. In 1925, the company was renamed the Aluminum Company of Canada. The Aluminum Company of Canada was ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Arvida, Quebec
Arvida ( ) is a settlement of 12,000 people (2010)Peritz, Ingrid, "Saguenay 'utopia' dreaming big again", ''The Globe and Mail'', 13 November 2010, p. A31 in Quebec, Canada, that is part of the City of Saguenay. Its name is derived from the name of its founder, Arthur Vining Davis, president of the Alcoa aluminum company. Arvida was founded as an industrial city by Alcoa in 1927, when the first aluminum smelter was constructed. Located north of Quebec City, south of the Saguenay River between Chicoutimi and Jonquière, the town was planned from the first day and was developed as a company town, to have a population of about 14,000 inhabitants, four Catholic parishes, and many other denominations, parishes and schools. It was known as "the City Built in 135 Days" and described by ''The New York Times'' as a "model town for working families" on "a North Canada steppe". History In 1912 James B. Duke purchased the rights to the power on the Saguenay River, and in 1925 the Isle Ma ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Human Genetics (journal)
''Human Genetics'' is a peer-reviewed medical journal covering all aspects of human genetics, including legal and social issues. It was established in 1964 by Arno Motulsky and Friedrich Vogel as the German-language ''Humangenetik'', obtaining its current title in 1976. It is published by Springer Science+Business Media. Its editors-in-chief are David N. Cooper (Cardiff University) and Thomas J. Hudson (Ontario Institute for Cancer Research). According to the ''Journal Citation Reports'', the journal has a 2018 impact factor of 5.20. Ethics scandal The journal published findings exploring the DNA of physical appearance traits of Uighur men from Tumxuk TumxukThe official spelling according to , (Beijing, ''SinoMaps Press'' 1997); is a sub-prefecture-level city in the western part of Xinjiang, China. The eastern part of Tumxuk is surrounded by Maralbexi County, Kashgar Prefecture. The smaller ... in 2019. One of the authors of the paper on DNA phenotyping said he had been ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Inflammatory Bowel Disease
Inflammatory bowel disease (IBD) is a group of inflammation, inflammatory conditions of the colon (anatomy), colon and small intestine, Crohn's disease and ulcerative colitis being the principal types. Crohn's disease affects the small intestine and large intestine, as well as the mouth, esophagus, stomach and the anus, whereas ulcerative colitis primarily affects the colon and the rectum. IBD also occurs in dogs and is thought to arise from a combination of host genetics, intestinal microenvironment, environmental components and the immune system. There is an ongoing discussion, however, that the term "chronic enteropathy" might be better to use than "inflammatory bowel disease" in dogs because it differs from IBD in humans in how the dogs respond to treatment. For example, many dogs respond to only dietary changes compared to humans with IBD, who often need Immunosuppression, immunosuppressive treatment. Some dogs may also need immunosuppressant or antibiotic treatment when dieta ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Type II Diabetes
Type 2 diabetes, formerly known as adult-onset diabetes, is a form of diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin. Common symptoms include increased thirst, frequent urination, and unexplained weight loss. Symptoms may also include increased hunger, feeling tired, and sores that do not heal. Often symptoms come on slowly. Long-term complications from high blood sugar include heart disease, strokes, diabetic retinopathy which can result in blindness, kidney failure, and poor blood flow in the limbs which may lead to amputations. The sudden onset of hyperosmolar hyperglycemic state may occur; however, ketoacidosis is uncommon. Type 2 diabetes primarily occurs as a result of obesity and lack of exercise. Some people are genetically more at risk than others. Type 2 diabetes makes up about 90% of cases of diabetes, with the other 10% due primarily to type 1 diabetes and gestational diabetes. In type 1 diabete ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
