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The Centre For Applied Genomics
The Centre for Applied Genomics is a genome centre in the Research Institute of The Hospital for Sick Children, Toronto, The Hospital for Sick Children, and is affiliated with the University of Toronto. TCAG also operates as a Science and Technology Innovation Centre oGenome Canada with an emphasis on next-generation sequencing (NGS) and bioinformatics support. Research at TCAG focuses on the genetics, genetic and genomic basis of human variability, health and disease, including research on the genetics of autism spectrum disorder and structural variation of the human genome. The centre is located in the Peter Gilgan Centre for Research and Learning in downtown Toronto, Canada. History The need for a centralized core facility for human genome research at The Hospital for Sick Children, Toronto, SickKids Hospital prompted the establishment of The Centre for Applied Genomics (TCAG) in 1998. The founding director and associate director were Drs. Lap-Chee Tsui and Stephen W. Scherer, r ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
TCAG Logo
The Centre for Applied Genomics is a genome centre in the Research Institute of The Hospital for Sick Children, Toronto, The Hospital for Sick Children, and is affiliated with the University of Toronto. TCAG also operates as a Science and Technology Innovation Centre oGenome Canada with an emphasis on next-generation sequencing (NGS) and bioinformatics support. Research at TCAG focuses on the genetics, genetic and genomic basis of human variability, health and disease, including research on the genetics of autism spectrum disorder and structural variation of the human genome. The centre is located in the Peter Gilgan Centre for Research and Learning in downtown Toronto, Canada. History The need for a centralized core facility for human genome research at The Hospital for Sick Children, Toronto, SickKids Hospital prompted the establishment of The Centre for Applied Genomics (TCAG) in 1998. The founding director and associate director were Drs. Lap-Chee Tsui and Stephen W. Scherer, r ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
OHRI
The Ottawa Hospital Research Institute (OHRI), formerly Ottawa Health Research Institute, is a non-profit academic health research institute located in the city of Ottawa. It was formed in 2001 following the merger of three Ottawa hospitals. The Ottawa Hospital Research Institute is the research arm of The Ottawa Hospital and affiliated with the University of Ottawa. As of 2022, the Ottawa Hospital Research Institute houses approximately 2,200 scientists, clinician investigators, students, research fellows, and support staff. It has five research programs: Cancer Therapeutics; Chronic Disease; Clinical Epidemiology; Regenerative Medicine; and Neurosciences. Its researchers are studying more than a hundred different diseases, conditions and specialties with an overall focus on translating discoveries and knowledge into better health. Ronald G. Worton was the research institute's founding CEO and Scientific Director in 2001. In 2007, Duncan Stewart, formerly Chief Cardiologist of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rett Syndrome
Rett syndrome (RTT) is a genetic disorder that typically becomes apparent after 6–18 months of age and almost exclusively in females. Symptoms include impairments in language and coordination, and repetitive movements. Those affected often have slower growth, difficulty walking, and a smaller head size. Complications of Rett syndrome can include seizures, scoliosis, and sleeping problems. The severity of the condition is variable. Rett syndrome is due to a genetic mutation in the MECP2 gene, on the X chromosome. It almost always occurs as a new mutation, with less than one percent of cases being inherited from a person's parents. It occurs almost exclusively in girls; boys who have a similar mutation typically die shortly after birth. Diagnosis is based on the symptoms and can be confirmed with genetic testing. There is no known cure for Rett syndrome. Treatment is directed at improving symptoms. Anticonvulsants may be used to help with seizures. Special education, ph ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Epilepsy
Epilepsy is a group of non-communicable neurological disorders characterized by recurrent epileptic seizures. Epileptic seizures can vary from brief and nearly undetectable periods to long periods of vigorous shaking due to abnormal electrical activity in the brain. These episodes can result in physical injuries, either directly such as broken bones or through causing accidents. In epilepsy, seizures tend to recur and may have no immediate underlying cause. Isolated seizures that are provoked by a specific cause such as poisoning are not deemed to represent epilepsy. People with epilepsy may be treated differently in various areas of the world and experience varying degrees of social stigma due to the alarming nature of their symptoms. The underlying mechanism of epileptic seizures is excessive and abnormal neuronal activity in the cortex of the brain which can be observed in the electroencephalogram (EEG) of an individual. The reason this occurs in most cases of epilepsy is u ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Johanna Rommens
Johanna Rommens is a Canadian geneticist who was on the research team which identified and cloned the CFTR gene, which when mutated, is responsible for causing cystic fibrosis (CF). She later discovered the gene responsible for Shwachman-Diamond syndrome, a rare genetic disorder that causes pancreatic and hematologic problems. She is a Senior Scientist Emeritus at SickKids Research Institute and a Professor in the Department of Molecular Genetics at the University of Toronto. Early life and education Rommens grew up on a farm in eastern New Brunswick, Canada. She earned both her bachelor's degree and a PhD in molecular biology from the University of New Brunswick in Fredericton. She was awarded a Beaverbrook Scholarship for her undergraduate education, and she earned a dual undergraduate degree in biology and organic chemistry. During her graduate education she studied synthetic chemistry in addition to molecular biology, and she received her PhD in 1986. In 1986, she started p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Medulloblastoma
Medulloblastoma is a common type of primary brain cancer in children. It originates in the part of the brain that is towards the back and the bottom, on the floor of the skull, in the cerebellum, or posterior fossa. The brain is divided into two main parts, the larger cerebrum on top and the smaller cerebellum below towards the back. They are separated by a membrane called the tentorium. Tumors that originate in the cerebellum or the surrounding region below the tentorium are, therefore, called infratentorial. Historically medulloblastomas have been classified as a primitive neuroectodermal tumor (PNET), but it is now known that medulloblastoma is distinct from supratentorial PNETs and they are no longer considered similar entities. Medulloblastomas are invasive, rapidly growing tumors that, unlike most brain tumors, spread through the cerebrospinal fluid and frequently metastasize to different locations along the surface of the brain and spinal cord. Metastasis all the way dow ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
PubMed
PubMed is a free search engine accessing primarily the MEDLINE database of references and abstracts on life sciences and biomedical topics. The United States National Library of Medicine (NLM) at the National Institutes of Health maintain the database as part of the Entrez system of information retrieval. From 1971 to 1997, online access to the MEDLINE database had been primarily through institutional facilities, such as university libraries. PubMed, first released in January 1996, ushered in the era of private, free, home- and office-based MEDLINE searching. The PubMed system was offered free to the public starting in June 1997. Content In addition to MEDLINE, PubMed provides access to: * older references from the print version of ''Index Medicus'', back to 1951 and earlier * references to some journals before they were indexed in Index Medicus and MEDLINE, for instance ''Science'', ''BMJ'', and ''Annals of Surgery'' * very recent entries to records for an article before it ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DNA Sequencing
DNA sequencing is the process of determining the nucleic acid sequence – the order of nucleotides in DNA. It includes any method or technology that is used to determine the order of the four bases: adenine, guanine, cytosine, and thymine. The advent of rapid DNA sequencing methods has greatly accelerated biological and medical research and discovery. Knowledge of DNA sequences has become indispensable for basic biological research, DNA Genographic Projects and in numerous applied fields such as medical diagnosis, biotechnology, forensic biology, virology and biological systematics. Comparing healthy and mutated DNA sequences can diagnose different diseases including various cancers, characterize antibody repertoire, and can be used to guide patient treatment. Having a quick way to sequence DNA allows for faster and more individualized medical care to be administered, and for more organisms to be identified and cataloged. The rapid speed of sequencing attained with modern D ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dna Microarray
A DNA microarray (also commonly known as DNA chip or biochip) is a collection of microscopic DNA spots attached to a solid surface. Scientists use DNA microarrays to measure the expression levels of large numbers of genes simultaneously or to genotype multiple regions of a genome. Each DNA spot contains picomoles (10−12 moles) of a specific DNA sequence, known as '' probes'' (or ''reporters'' or '' oligos''). These can be a short section of a gene or other DNA element that are used to hybridize a cDNA or cRNA (also called anti-sense RNA) sample (called ''target'') under high-stringency conditions. Probe-target hybridization is usually detected and quantified by detection of fluorophore-, silver-, or chemiluminescence-labeled targets to determine relative abundance of nucleic acid sequences in the target. The original nucleic acid arrays were macro arrays approximately 9 cm × 12 cm and the first computerized image based analysis was published in 1981. It was inv ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genomic
Genomics is an interdisciplinary field of biology focusing on the structure, function, evolution, mapping, and editing of genomes. A genome is an organism's complete set of DNA, including all of its genes as well as its hierarchical, three-dimensional structural configuration. In contrast to genetics, which refers to the study of ''individual'' genes and their roles in inheritance, genomics aims at the collective characterization and quantification of ''all'' of an organism's genes, their interrelations and influence on the organism. Genes may direct the production of proteins with the assistance of enzymes and messenger molecules. In turn, proteins make up body structures such as organs and tissues as well as control chemical reactions and carry signals between cells. Genomics also involves the sequencing and analysis of genomes through uses of high throughput DNA sequencing and bioinformatics to assemble and analyze the function and structure of entire genomes. Advances in gen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MaRS Discovery District
MaRS Discovery District is a not-for-profit corporation founded in Toronto, Ontario, Canada in 2000. Its stated goal is to commercialize publicly funded medical research and other technologies with the help of local private enterprises and as such is a public-private partnership. As part of its mission MaRS says, "MaRS helps create successful global businesses from Canada's science, technology and social innovation." , startup companies emerging from MaRS had created more than 4,000 jobs, and in the period of 2011 to 2014 had raised over $750 million in capital investments. The name MaRS was originally drawn from a file name, and later attributed with the title "Medical and Related Sciences." It has since abandoned this association as it also works in other fields such as information and communications technology, engineering, and social innovation. Facilities It is located on the corner of College Street and University Avenue in the city of Toronto’s Discovery Distri ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mount Sinai Hospital (Toronto)
Mount Sinai Hospital (MSH) is a hospital in Toronto, Ontario, Canada. Mount Sinai is part of Sinai Health System, Sinai Health. Sinai Health was formed through the voluntary amalgamation of Mount Sinai Hospital (including the Lunenfeld-Tanenbaum Research Institute) and Bridgepoint Active Healthcare, Hennick Bridgepoint Hospital on January 22, 2015. Mount Sinai is linked by bridges and tunnels to three adjacent hospitals of the University Health Network (Toronto General Hospital, Toronto Rehabilitation Institute, and Princess Margaret Cancer Centre). During the 2005 annual charity, the hospital reported to the Canada Revenue Agency as having assets of roughly Canadian dollar, C$ 520 million. In the 2019-2020 fiscal year there were nearly 29,000 inpatient stays and 59,700 emergency department visits for Mount Sinai Hospital. The average length of stay for inpatients was 4.4 days. Mount Sinai Hospital has existed in Toronto since 1923 under various names; it has occupied its present ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
